13 completed, 4 recruiting, 4 terminated, 4 unknown. 31 Phase 3, 13 Phase 2.
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 60 | 2026-12-01 | 2026-10-21 |
| A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis Veverimer, Placebo - CKD, Metabolic Acidosis | Phase 3 | Recruiting | Renibus Therapeutics, Inc. | 150 | 2026-01-13 | 2026-10-23 |
| Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session, Placebo beverage - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 30 | 2025-08-01 | 2026-11-05 |
| Effects of Ketone Supplement and Alcohol on Brain Metabolism Kenetik, Alcohol beverage - Ketosis, Alcohol Drinking | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 60 | 2025-05-13 | 2026-10-14 |
| REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis Reamberin, Placebo - Diabetic Ketoacidosis | Phase 2 / Phase 3 | Recruiting | POLYSAN Scientific & Technological Pharmaceutical Company | 312 | 2025-05-01 | 2025-06-24 |
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN. - Metabolic Acidosis, Neonatal Disease | Phase 3 | Unknown | Aga Khan University Hospital, Pakistan | 200 | 2024-07-10 | 2024-08-09 |
| Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis Plasma-Lyte 148, 0.9% sodium chloride - Diabetic Ketoacidosis | Phase 3 | Completed | The George Institute | 547 | 2024-03-14 | 2026-10-05 |
| Effects of Ketone Supplementation on Acute Alcohol Withdrawal Kenetik; Ketone Concentrate, Isocaloric dextrose placebo - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Enrolling by invitation | University of Pennsylvania | 50 | 2024-03-11 | 2026-04-06 |
| Effect of Nutritional Ketosis on Alcohol Metabolism Ketone Supplement, Control Diet, Ketogenic diet - Ketoses, Metabolic, Ketogenic Dieting | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 23 | 2024-02-29 | 2026-04-07 |
| Extension Study in Primary Distal Renal Tubular Acidosis ADV7103 - Acidosis, Renal Tubular | Phase 3 | Withdrawn | Advicenne Pharma | 2023-12-20 | 2026-02-09 | |
| SODium BICarbonate for Metabolic Acidosis in the ICU Sodium bicarbonate, 5% Dextrose - Metabolic Acidosis, Shock | Phase 3 | Active not recruiting | Australian and New Zealand Intensive Care Research Centre | 500 | 2023-04-26 | 2026-03-27 |
| Study Evaluating Subjects With Distal Renal Tubular Acidosis ADV7103, Placebo - Distal Renal Tubular Acidosis | Phase 3 | Terminated | Advicenne Pharma | 3 | 2021-09-20 | 2026-06-03 |
| Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease Sodium zirconium cyclosilicate, Placebo - Hyperkalaemia, Metabolic Acidosis | Phase 3 | Terminated | AstraZeneca | 39 | 2021-03-22 | 2023-10-06 |
| Exogenous Ketones for Acutely Decompensated HEart Failure 25g Ketone monoester without added salts, Placebo - Acute Heart Failure, Low Cardiac Output Syndrome | Phase 3 | Unknown | Institute for Clinical and Experimental Medicine | 24 | 2020-12-02 | 2021-01-06 |
| Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis TRC101, Placebo - Metabolic Acidosis, Chronic Kidney Disease | Phase 3 | Terminated | Tricida, Inc. | 1480 | 2018-11-20 | 2022-10-14 |
| Long-term Safety Extension to Study TRCA-301 TRC101, Placebo - Metabolic Acidosis | Phase 3 | Completed | Tricida, Inc. | 196 | 2017-12-20 | 2021-10-22 |
| Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease TRC101, Placebo - Metabolic Acidosis | Phase 3 | Completed | Tricida, Inc. | 217 | 2017-09-26 | 2021-04-26 |
| Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime Plasmalyte A, Ringer Lactate - Cardiopulmonary Bypass | Phase 3 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 60 | 2017-02-10 | 2017-02-03 |
| Alcohol: Thiamine and or Magnesium 1 Magnesium Sulfate, Pabrinex - Alcohol Withdrawal, Lactic Acidosis | Phase 2 / Phase 3 | Completed | Glasgow Royal Infirmary | 127 | 2016-12-16 | 2019-07-31 |
Showing 20 of 31. Sign in to see all of them.
Ketosis (8) · Renal Insufficiency, Chronic (5) · Acidosis, Lactic (3) · Alcoholism (3) · Diabetic Ketoacidosis (3) · Kidney Diseases (3) · Acidosis, Renal Tubular (2) · Alcohol Drinking (2) · Shock (2) · Acidosis, Respiratory (1) · Alcoholic Intoxication (1) · Alzheimer Disease (1) · Beriberi (1) · Bone Diseases, Metabolic (1)
Acid-Base Imbalance (31) · Metabolic Diseases (31) · Nutritional and Metabolic Diseases (31) · Pathological Conditions, Signs and Symptoms (13) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Male Urogenital Diseases (9) · Urogenital Diseases (9) · Urologic Diseases (9) · Pathologic Processes (8) · Disease Attributes (6) · Kidney Diseases (6) · Mental Disorders (6) · Alcohol-Related Disorders (5)
Sodium Bicarbonate (4) · veverimer (4) · Ethanol (3) · Potassium Citrate (3) · Sodium Chloride (2) · Alcoholic Beverages (1) · Alkalies (1) · Bicarbonates (1) · Citric Acid (1) · Dichloroacetic Acid (1) · Diet, Ketogenic (1) · Dietary Supplements (1) · Glucose (1) · Ketones (1) · Magnesium Sulfate (1)
University of Pennsylvania (5) · Albert Einstein College of Medicine (3) · Tricida, Inc. (3) · Advicenne Pharma (2) · Aga Khan University Hospital, Pakistan (1) · AstraZeneca (1) · Australian and New Zealand Intensive Care Research Centre (1) · Azienda Sanitaria ASL Avellino 2 (1) · Cerecin (1) · Glasgow Royal Infirmary (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Institute for Clinical and Experimental Medicine (1) · Johns Hopkins University (1) · Kantonsspital Baselland Bruderholz (1) · POLYSAN Scientific & Technological Pharmaceutical Company (1)
United States (18) · Australia (3) · Bulgaria (3) · Canada (3) · Georgia (3) · Hungary (3) · Serbia (3) · Ukraine (3) · United Kingdom (3) · Brazil (2) · Czechia (2) · France (2) · Italy (2) · Slovenia (2) · Albania (1)
Corinde Wiers, Ph.D. (4) · Thomas Hostetter, MD (2) · Andre Ulmann, M.D., Ph.D. (1) · Ary Serpa Neto, PhD (1) · Biagio Di Iorio, MD, PhD (1) · Corinde E Wiers, Ph.D. (1) · Donogh Maguire, MB BCh (1) · Eric H Kossoff, MD (1) · Henry Kranzler, MD (1) · Julio Montaner, MD (1) · Kimberly Reidy, MD (1) · Kyle Kampman, MD (1) · Laurence Greenbaum, MD, Ph.D. (1) · Mildred Farmer, MD (1)
PMID 10102718, PMID 11046201, PMID 12243433, PMID 15115561, PMID 15591303, PMID 18666740, PMID 19115651, PMID 23393105, PMID 24415398, PMID 27770799, PMID 28606907, PMID 29866165, PMID 29910040, PMID 30857647, PMID 31248662, PMID 31598912, PMID 31699517, PMID 34009141, PMID 34784301, PMID 35216581, PMID 35484175, PMID 38261535, PMID 38622759, PMID 39665575, PMID 401925, PMID 40487345, PMID 42283370, PMID 8161863
R21AA031088 (2), 2016 (1), 2018 (1), 2023 (1), R01AA031570 (1), R01DK087783 (1), R01DK131811 (1), R21AA031337 (1), U01HD062417 (1)