112 completed, 8 unknown, 5 terminated, 2 suspended. 46 Phase 2, 29 Phase 3, 25 Not applicable, 16 Phase 4, 15 Phase 1.
Follow Stavudine: new trials by email Literature Review of Stavudine trials Research Report on Stavudine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Optimisation of Stavudine for the Treatment of HIV Infection Stavudine, Tenofovir Disoproxil Fumarate - Acquired Immune Deficiency Syndrome, Human Immunodeficiency Virus | Phase 3 | Completed | Willem Daniel Francois Venter | 1077 | 2012-07-01 | 2016-02-02 |
| Cryptococcal Optimal ART Timing Trial efavirenz, nucleoside - Cryptococcal Meningitis, HIV Infections | Phase 4 | Completed | University of Minnesota | 177 | 2010-11-01 | 2020-06-09 |
| Treatment Options for Protease Inhibitor-exposed Children Efavirenz (EFV), Lopinavir/ritonavir (LPV/r), Stavudine (D4T) - HIV/AIDS, HIV Infections | Phase 3 | Completed | Columbia University | 300 | 2010-07-01 | 2017-03-13 |
| Differences Between Stavudine and Tenofovir Each Combined With Lamivudine and Efavirenz in SA HIV-infected Patients Stavudine, Tenofovir - Mitochondrial Toxicity, Metabolic Complications | Phase 4 | Terminated | University of Witwatersrand, South Africa | 60 | 2008-10-01 | 2012-05-18 |
| Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ ARV's + Placebo, Naltrexone, Naltrexone + ARV's - HIV Seropositivity | Phase 2 | Completed | The Ojai Foundation | 171 | 2008-03-01 | 2010-08-04 |
| Optimizing Pediatric HIV-1 Treatment in Infants With Prophylactic Exposure to Nevirapine, Nairobi, Kenya AZT/3TC/NVP (zidovudine/lamivudine/nevirapine), d4T/3TC/NVP (stavudine/lamivudine/nevirapine), AZT/3TC/ABC (zidovudine/lamivudine/abacavir) - HIV Infections | Phase 3 | Terminated | University of Washington | 34 | 2007-09-01 | 2018-08-27 |
| Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa Structured treatment interruption, Lamivudine, Lopinavir/Ritonavir - HIV Infections | Not applicable | Completed | The Wistar Institute | 30 | 2007-03-01 | 2014-08-27 |
| Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children Tenofovir DF, Zidovudine, Stavudine - HIV Infections | Phase 3 | Completed | Gilead Sciences | 97 | 2006-12-28 | 2018-03-14 |
| Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children Lamivudine, nevirapine, and stavudine fixed-dose tablet, Lamivudine, Nevirapine - HIV Infections | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 44 | 2006-12-01 | 2021-11-02 |
| Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa Fluconazole, Fixed dose - Stavudine, lamivudine and Nevirapine, Fixed dose - Stavudine, Lamivudine, Nevirapine - Cryptococcal Meningitis, HIV Infections | Not applicable | Completed | University of Zimbabwe | 54 | 2006-10-01 | 2016-07-18 |
| Evaluation of Two Anti-HIV Treatment Strategies in Resource-Limited South African Communities Monitoring by an HIV-trained medical doctor, Monitoring by an HIV-trained primary care nurse, Efavirenz - HIV Infections | Not applicable | Completed | CIPRA SA | 812 | 2006-07-01 | 2011-06-21 |
| Triomune Bioequivalence With Innovators Triomune, Zerit/Epivir/Viramune - HIV/AIDS | Phase 4 | Completed | Makerere University | 20 | 2006-02-01 | 2010-01-05 |
| Strategies for Delivering Anti-HIV Therapy in South Africa Monitoring by HIV-trained primary care nurses, Community-based directly observed therapy (DOT), stavudine - HIV Infections | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 813 | 2005-02-01 | 2007-09-18 |
| Preventing Sexual Transmission of HIV With Anti-HIV Drugs Atazanavir, Didanosine, Efavirenz - HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 3526 | 2005-02-01 | 2021-11-05 |
| Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese Patients:Multicentric Observation Cohort Zidovudine (AZT)+ Didanosine (ddI)+ Nevirapine (NVP), Stavudine (d4T), Lamivudine (3TC), Nevirapine (NVP), Zidovudine (AZT), Lamivudine (3TC), Nevirapine (NVP) - HIV Infections | Phase 4 | Completed | Peking Union Medical College | 198 | 2005-01-01 | 2008-03-24 |
| Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY stavudine - HIV | Phase 4 | Unknown | Groupe Hospitalier Pitie-Salpetriere | 57 | 2004-06-01 | 2005-10-25 |
| 2NN & CHARM Long-Term Follow-up Study stavudine, lamivudine, nevirapine - HIV Infections | Phase 4 | Completed | International Antiviral Therapy Evaluation Center | 763 | 2004-02-01 | 2007-04-30 |
| A Comparison of Two Dose Levels of Didanosine Used in Combination With Stavudine in HIV-Infected Patients Stavudine, Didanosine - HIV Infections | Not applicable | Completed | Bristol-Myers Squibb | 2004-02-01 | 2011-04-25 | |
| Antiretroviral Therapy for Advanced HIV Disease in South Africa Zidovudine, Stavudine, Didanosine - HIV | Phase 4 | Completed | National Institutes of Health Clinical Center (CC) | 1771 | 2004-01-01 | 2013-05-21 |
| A Prospective Cohort of Children With HIV Infection Zidovudine, Stavudine, Didanosine, Lamivudine, Nevirapine, Efavirenz, LPV/r, Saquinavir, Indinavir, Ritonavir, Nelfinavir - HIV Infections | Completed | The HIV Netherlands Australia Thailand Research Collaboration | 500 | 2003-03-01 | 2025-03-17 |
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HIV Infections (120) · Acquired Immunodeficiency Syndrome (22) · AIDS-Related Complex (12) · Lipodystrophy (3) · AIDS-Related Opportunistic Infections (2) · Disease Progression (2) · Insulin Resistance (2) · Meningitis, Cryptococcal (2) · AIDS Dementia Complex (1) · AIDS-Associated Nephropathy (1) · Acidosis, Lactic (1) · Cardiovascular Diseases (1) · Cryptococcosis (1) · Directly Observed Therapy (1) · HIV Seropositivity (1)
National Institute of Allergy and Infectious Diseases (NIAID) (53) · Bristol-Myers Squibb (18) · Merck Sharp & Dohme LLC (8) · Gilead Sciences (4) · Hoffmann-La Roche (4) · Triangle Pharmaceuticals (4) · Glaxo Wellcome (3) · Abbott (2) · Boehringer Ingelheim (2) · Dupont Merck (2) · Agouron Pharmaceuticals (1) · CIPRA SA (1) · Columbia University (1) · Groupe Hospitalier Pitie-Salpetriere (1) · Harvard School of Public Health (HSPH) (1)
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PMID 24326304, PMID 33901188, PMID 15687448, PMID 18090046, PMID 24979445, PMID 32829410, PMID 38160309, PMID 10659875, PMID 10954886, PMID 11306155, PMID 11372025, PMID 11840078, PMID 11880966, PMID 11927734, PMID 11980557, PMID 14668455, PMID 14668456, PMID 14669723, PMID 15115831, PMID 15187476, PMID 15892437, PMID 16048984, PMID 16103764, PMID 16159645, PMID 16220085, PMID 16267764, PMID 16287792, PMID 16547789, PMID 16810109, PMID 16905783, PMID 17174704, PMID 17280617, PMID 17310819, PMID 17357053, PMID 17527093, PMID 17662759, PMID 1783744, PMID 18042503, PMID 18176329, PMID 18193496, PMID 18480202, PMID 18977721, PMID 19008157, PMID 19081791, PMID 19096711, PMID 19417580, PMID 19440326, PMID 19597072, PMID 19696651, PMID 20102271
U19AI053217 (2), K24AI051966 (1), R01AI051986 (1), R01DK056583 (1), R01HD023412 (1), R01HD061255 (1), R01HL065953 (1), U01AI089244 (1)