14 completed, 7 unknown, 4 terminated, 2 recruiting. 29 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 29 | Completed 14, Unknown 7, Terminated 4, Recruiting 2, Not yet recruiting 1, Withdrawn 1 |
Follow Trauma: new trials by email Literature Review of Trauma trials Research Report on Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Powdered Intrawound Vancomycin in Open Fractures Trial Vancomycin 1000 MG - Open Fracture, Trauma | Phase 4 | Not yet recruiting | University of Manitoba | 350 | 2024-11-01 | 2024-09-19 |
| Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures Narcotic pain medication, Nonnarcotic pain medications - Opioid Use, Fractures, Bone | Phase 4 | Recruiting | Henry Ford Health System | 75 | 2024-10-01 | 2026-10-27 |
| Restrictive Vs. Liberal Oxygen in Trauma Restrictive oxygen, Liberal oxygen - Trauma, Oxygen Toxicity | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 1508 | 2021-12-10 | 2024-10-22 |
| Continuous Erector Spinae Plane Blocks for Rib Fractures Active ropivacaine 0.3% erector spinae plane perineural administration, Placebo erector spinae plane perineural administration - Rib Fractures, Trauma | Phase 4 | Terminated | University of California, San Diego | 4 | 2021-05-23 | 2023-06-12 |
| Pregabalin vs. Gabapentin on Reducing Opioid Usage Pregabalin 50mg, Gabapentin 300mg, Neither Pregabalin nor Gabapentin - Analgesics, Gabapentin | Phase 4 | Completed | CAMC Health System | 109 | 2021-04-12 | 2026-01-06 |
| Prehospital Analgesia in Adults Using Inhaled Methoxyflurane : A Feasibility Study Methoxyflurane - Pain, Acute, Trauma | Phase 4 | Completed | Ottawa Hospital Research Institute | 97 | 2021-04-12 | 2023-02-28 |
| Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status Placebo, Propranolol - Trauma, Brain Injuries | Phase 4 | Unknown | Hamad Medical Corporation | 771 | 2020-12-29 | 2023-09-28 |
| Magnesium Infusion for Pain Management in Critically Ill Trauma Patients Magnesium Sulfate in Parenteral Dosage Form, Normal saline placebo - Trauma, Acute Pain | Phase 4 | Recruiting | University of California, Davis | 156 | 2019-12-07 | 2025-11-26 |
| NSAIDS vs Opioids in Tibial Fractures NSAIDs - Trauma | Phase 4 | Unknown | University of Louisville | 100 | 2019-11-12 | 2022-04-18 |
| Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures Intravenous Ketamine, Intranasal Ketamine - Trauma, Fractures, Closed | Phase 4 | Terminated | University of Alabama at Birmingham | 40 | 2019-09-09 | 2023-04-20 |
| Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl Methoxyflurane (M), Fentanyl (F1), Fentanyl (F2) - Acute Pain, Trauma | Phase 4 | Completed | Oslo University Hospital | 12 | 2019-04-23 | 2019-11-19 |
| Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures Bupivacaine Liposome Injection, Bupivacaine - Trauma, Trauma Injury | Phase 4 | Unknown | Chadrick Evans | 258 | 2018-08-29 | 2020-03-09 |
| Restrictive vs. Liberal Oxygen Therapy for Trauma Patients Titrated Oxygen, Liberal Oxygen - Trauma, Wounds and Injuries | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 41 | 2018-04-03 | 2018-08-14 |
| Assessment of Valproate on Ethanol Withdrawal Valproate, Lorazepam - Alcohol Dependence, Alcohol Withdrawal Syndrome | Phase 4 | Terminated | CAMC Health System | 3 | 2017-07-11 | 2026-08-18 |
| The New Skin Stretching Device for Treatment of Limb Tension Wounds Skin stretching device (SSD), Skin grafting - Trauma, Fractures, Open | Phase 4 | Unknown | The First Affiliated Hospital of Dalian Medical University | 100 | 2017-05-11 | 2017-05-05 |
| Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery Tranexamic acid injection, Normal Saline - Tranexamic Acid, Trauma | Phase 4 | Completed | Jaspreet Singh | 100 | 2017-04-01 | 2021-08-03 |
| Aspirin and Enoxaparin for VTE in Trauma Aspirin, Enoxaparin - Venous Thromboembolism, Thromboprophylaxis | Phase 4 | Terminated | University of Miami | 31 | 2016-02-01 | 2019-11-19 |
| Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial Fibrinogen concentrate - Trauma, Bleeding Disorder | Phase 4 | Completed | University of Sao Paulo General Hospital | 32 | 2015-12-01 | 2018-08-01 |
| Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients Ascorbic Acid - Multiple Organ Failure, Sepsis | Phase 4 | Completed | Amsterdam UMC, location VUmc | 20 | 2015-03-01 | 2017-08-02 |
| Comparison of Oral 30 % Dextrose and iv Midazolam Sedation During MRI in Neonates oral 30% glucose, IV midazolam - Epilepsy, Trauma | Phase 4 | Unknown | Baskent University | 112 | 2015-01-01 | 2016-01-01 |
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Wounds and Injuries (29) · Acute Pain (4) · Fractures, Bone (3) · Pain (3) · Brain Injuries (2) · Emergencies (2) · Fractures, Open (2) · Hemostatic Disorders (2) · Venous Thrombosis (2) · Accidental Injuries (1) · Afibrinogenemia (1) · Agnosia (1) · Alcoholism (1) · Blood Coagulation Disorders (1) · Brain Injuries, Traumatic (1)
Pathological Conditions, Signs and Symptoms (12) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Pathologic Processes (6) · Cardiovascular Diseases (5) · Vascular Diseases (5) · Nervous System Diseases (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Embolism and Thrombosis (3) · Fractures, Bone (3) · Pain (3) · Craniocerebral Trauma (2) · Disease Attributes (2) · Hematologic Diseases (2)
Enoxaparin (2) · Fentanyl (2) · Ibuprofen (2) · Methoxyflurane (2) · Midazolam (2) · Saline Solution (2) · Analgesics (1) · Analgesics, Opioid (1) · Anesthesia, Conduction (1) · Anesthesia, General (1) · Anesthetics, Local (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Ascorbic Acid (1) · Aspirin (1) · BID protein, human (1)
CAMC Health System (2) · Copenhagen University Hospital, Rigshospitalet (2) · Ottawa Hospital Research Institute (2) · Amsterdam UMC, location VUmc (1) · Baskent University (1) · Chadrick Evans (1) · Craig Hospital (1) · Genesys (1) · Hamad Medical Corporation (1) · Henry Ford Health System (1) · Jaspreet Singh (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Oregon Health and Science University (1) · Oslo University Hospital (1) · Seoul St. Mary's Hospital (1)
United States (12) · Canada (5) · China (2) · Denmark (2) · Netherlands (2) · Brazil (1) · India (1) · Italy (1) · Norway (1) · Qatar (1) · South Korea (1) · Switzerland (1)
Jacob Steinmetz, MD, PhD (2) · Anis Aribogan, Prof (1) · Audis Bethea, PharmD, BCPS (1) · Ayman El-Menyar, MD (1) · Brian M Ilfeld, MD, MS (1) · Chadrick R Evans, MD (1) · David Ripley, MD (1) · David T Neilipovitz, MD (1) · Douglas D Fraser, MD, PhD (1) · Gabriel Larose, MD, MSc, FRCSC (1) · Giorgio Danelli, MD (1) · Guido Fanelli, MD (1) · Gurinder S Sangha, MD (1) · Gurleen Kaur, MD (1)
PMID 12576361, PMID 15576519, PMID 16625122, PMID 17006084, PMID 19247744, PMID 19254307, PMID 19359920, PMID 20048659, PMID 21256488, PMID 21716105, PMID 22695321, PMID 23059961, PMID 23403516, PMID 23614099, PMID 24108252, PMID 24458051, PMID 25210700, PMID 25527168, PMID 25683770, PMID 25912739, PMID 26204387, PMID 26507422, PMID 26604819, PMID 26985786, PMID 27533913, PMID 29522710, PMID 30233155, PMID 30908592, PMID 32250330, PMID 32797734, PMID 33676727, PMID 34755760, PMID 34876207, PMID 36344005, PMID 36906804, PMID 39179700, PMID 39657224, PMID 42817920, PMID 496064, PMID 5007074, PMID 6003600
2014 (1), 2018 (1)