19 completed, 4 unknown, 3 not yet recruiting, 1 withdrawn. 12 Phase 4, 10 Phase 3, 4 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 8, Unknown 4 |
| Phase 3 | 10 | Completed 8, Not yet recruiting 2 |
| Not applicable | 4 | Completed 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Methoxyflurane: new trials by email Literature Review of Methoxyflurane trials Research Report on Methoxyflurane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methoxyflurane Versus Usual Care for Non-Traumatic Pain in Emergency Departments Analgesic management with Methoxyflurane as first-line treatment, Pain treatment according to the usual analgesic management protocol of the emergency department of the participating center. - Pain Management | Phase 3 | Not yet recruiting | University Hospital, Tours | 164 | 2026-09-16 | 2026-08-03 |
| Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction Methoxyflurane, Morphine - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 700 | 2026-06-01 | 2026-03-03 |
| 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion Methoxyflurane, Saline - IUD | Phase 4 | Completed | Women's College Hospital | 110 | 2026-04-27 | 2026-10-13 |
| Methoxyflurane for Analgesia During Hysteroscopy Anesthetics, Inhalation, Intravenous Sedatives with or Without Analgesia - Analgesia | Not applicable | Not yet recruiting | Dr. John A. Thiel Medical Professional Corporation | 54 | 2025-06-01 | 2025-03-28 |
| Study of the Use of Methoxyflurane vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: METODO (METhoxyflurane in ODOntology) Experimenta group (standard of care + Methoxyflurane)., control group (standard of care + placebo). - Dental Pain and Sensation Disorder | Phase 3 | Completed | University Hospital, Brest | 190 | 2024-10-14 | 2026-06-12 |
| Prehospital Analgesia in Adults Using Inhaled Methoxyflurane Study Methoxyflurane, Standard Care - Pain, Acute | Phase 4 | Unknown | Ottawa Hospital Research Institute | 1800 | 2024-08-01 | 2024-07-19 |
| Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study Methoxyflurane, Control - Scrotum Disease, Hydrocele Male | Phase 2 | Completed | University of Manitoba | 40 | 2024-04-17 | 2025-09-25 |
| Prehospital Inhaled Methoxyflurane Non-Clinical Occupational Exposure Study Methoxyflurane - Occupational Exposure | Phase 4 | Unknown | Ottawa Hospital Research Institute | 30 | 2023-09-01 | 2024-07-19 |
| A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine Methoxyflurane, Fentanyl, Morphine hydrochloride - Acute Pain, Ambulances | Phase 3 | Completed | Oslo University Hospital | 338 | 2021-11-12 | 2023-11-14 |
| Prehospital Analgesia in Adults Using Inhaled Methoxyflurane : A Feasibility Study Methoxyflurane - Pain, Acute, Trauma | Phase 4 | Completed | Ottawa Hospital Research Institute | 97 | 2021-04-12 | 2023-02-28 |
| A Pilot Study on the Use of Methoxyflurane (Penthrox®) for Pain Control in the Emergency Department Methoxyflurane, Ketorolac - Acute Traumatic Pain | Phase 3 | Completed | Hospital Authority, Hong Kong | 40 | 2020-10-28 | 2020-12-08 |
| Low Dose Methoxyflurane and Out-Patient Aesthetic Surgery and Facial Filler Methoxyflurane - Pain | Not applicable | Withdrawn | Verso Surgery Centre | 2020-07-01 | 2023-05-06 | |
| Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris Ticagrelor followed with Methoxyflurane, Ticagrelor followed with Morphine, Ticagrelor alone - Unstable Angina | Phase 4 | Completed | Collegium Medicum w Bydgoszczy | 72 | 2020-06-01 | 2024-03-12 |
| Low Dose Methoxyflurane for Pain Relief During Minor Out-patient Urologic Procedures Methoxyflurane, MEOF - Pain, Acute | Phase 4 | Unknown | Sunnybrook Health Sciences Centre | 10 | 2020-05-31 | 2020-06-02 |
| Penthrox in Rezūm BPH Methoxyflurane - Pain, BPH | Phase 4 | Completed | Dean Elterman | 10 | 2019-09-10 | 2022-01-24 |
| Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma Methoxyflurane - Pain, Traumatic Injury | Not applicable | Completed | University Hospital, Tours | 34 | 2019-06-07 | 2021-05-06 |
| Reduction of Anterior Shoulder Dislocation Facilitated by Inhaled Low Dose Methoxyflurane Methoxyflurane - Shoulder Dislocation | Not applicable | Completed | Nova Scotia Health Authority | 20 | 2019-06-01 | 2023-06-15 |
| MethOxyflUraNe at moderaTe High AltItudes for PAIN Management Methoxyflurane, Placebo - Pain | Phase 4 | Unknown | University of Cape Town | 24 | 2019-05-01 | 2019-02-21 |
| Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl Methoxyflurane (M), Fentanyl (F1), Fentanyl (F2) - Acute Pain, Trauma | Phase 4 | Completed | Oslo University Hospital | 12 | 2019-04-23 | 2019-11-19 |
| PENTHROX™ in the Canadian Emergency Department (ED) Methoxyflurane 3mL - Pain, Acute | Phase 4 | Completed | Purdue Pharma, Canada | 99 | 2019-04-08 | 2021-09-16 |
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Acute Pain (8) · Pain (7) · Agnosia (4) · Wounds and Injuries (4) · Emergencies (3) · Angina, Unstable (1) · Chest Pain (1) · Hematocele (1) · Hypovolemia (1) · Neoplasms (1) · ST Elevation Myocardial Infarction (1) · Sensation Disorders (1) · Shoulder Dislocation (1) · Spermatocele (1) · Toothache (1)
Medical Developments International Limited (3) · Ottawa Hospital Research Institute (3) · Oslo University Hospital (2) · University Hospital, Tours (2) · Assistance Publique - Hôpitaux de Paris (1) · Collegium Medicum w Bydgoszczy (1) · Dean Elterman (1) · Dr. John A. Thiel Medical Professional Corporation (1) · Hospital Authority, Hong Kong (1) · Mundipharma Pharmaceuticals S.L. (1) · Mundipharma Pharmaceuticals srl (1) · Mundipharma SAS (1) · Nova Scotia Health Authority (1) · Purdue Pharma, Canada (1) · Sunnybrook Health Sciences Centre (1)
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