18 completed, 8 terminated, 7 unknown, 5 recruiting. 14 Not applicable, 13 Phase 4, 5 Phase 3, 1 Phase 2.
Follow Fractures, Open: new trials by email Literature Review of Fractures, Open trials Research Report on Fractures, Open
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries Accelerated Flap Coverage Surgery, Standard of Care Flap Timing - Open Tibia Fracture, Open Dislocation of Ankle | Not applicable | Not yet recruiting | Johns Hopkins University | 356 | 2027-01-01 | 2026-09-18 |
| SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol Surgery Complications, Surgery | Not yet recruiting | University of Birmingham | 100000 | 2026-08-31 | 2026-08-25 | |
| Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures Vancomycin (VAN) treatment, Standard Open Fracture Care - Open Fracture | Phase 3 | Not yet recruiting | Atlantic Health System | 100 | 2026-06-10 | 2026-06-22 |
| Volume Reduction for Open Fracture Irrigation 0.9% Sodium Chloride - Open Fracture | Phase 4 | Recruiting | Inova Health Care Services | 200 | 2026-03-02 | 2026-04-13 |
| Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System Fitbone Transport and Lengthening System - Fractures, Bone, Fractures, Closed | Terminated | Orthofix Inc. | 1 | 2024-11-19 | 2026-04-02 | |
| Powdered Intrawound Vancomycin in Open Fractures Trial Vancomycin 1000 MG - Open Fracture, Trauma | Phase 4 | Not yet recruiting | University of Manitoba | 350 | 2024-11-01 | 2024-09-19 |
| AI Assisted Detection of Fractures on X-Rays (FRACT-AI) Cases reading, Ground truthing - Fracture, Bone Fracture | Completed | Oxford University Hospitals NHS Trust | 21 | 2024-02-08 | 2025-11-24 | |
| Evaluation of STIMULAN Device and AI Model in Preventing Fracture Infections STIMULAN - Open Fracture | Not applicable | Unknown | Università Vita-Salute San Raffaele | 40 | 2023-11-01 | 2024-04-25 |
| Antibiotic Prophylaxis in Pediatric Open Fractures Cefazolin, Cephalexin - Fractures, Open, Infections | Phase 4 | Enrolling by invitation | St. Louis University | 800 | 2023-09-11 | 2025-10-20 |
| OCT in Open Fracture and Infected Fracture Open Fracture, Infected Fracture - Trauma Injury, Trauma | Recruiting | Dartmouth-Hitchcock Medical Center | 40 | 2023-03-27 | 2026-10-02 | |
| Ganga Hospital Scoring System In Type-IIIA/B Open Tibial Fractures BKA, Debridement with Ex_Fix (salvage) - Fractures, Open | Unknown | Assiut University | 87 | 2022-12-01 | 2022-08-18 | |
| Tobramycin Injection to Prevent Infection in Open Fractures Tobramycin Injection - Wound Infection, Fractures, Open | Phase 3 | Completed | Massachusetts General Hospital | 600 | 2022-01-10 | 2026-09-16 |
| LOQTEQ® Antibacterial Pre-Market Study Implantation - Fractures, Open, Fractures, Closed | Not applicable | Completed | aap Implantate AG | 203 | 2021-12-09 | 2025-09-18 |
| 3D Printed Titanium Mesh vs Guided Autogenous Graft orbital floor recontriction - Orbital Floor (Blow-Out) Open Fracture, Enophthalmos Traumatic | Phase 2 / Phase 3 | Unknown | Mohammed Ghassan Mohammed Shaalan | 32 | 2021-09-01 | 2022-09-22 |
| FastFrame Knee Spanning and Damage Control Kit PMCF FastFrame External Fixation System - Knee Spanning or Damage Control Kit - Fracture, Fractures, Bone | Not applicable | Terminated | Zimmer Biomet | 33 | 2021-06-18 | 2025-02-10 |
| Acute Application of Antibiotic Powder in Open Fracture Wounds Vancomycin, Tobramycin - Fractures, Open, Wounds and Injuries--Infections | Phase 4 | Completed | University of Colorado, Denver | 20 | 2021-06-14 | 2026-03-06 |
| Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care Vivigen Cellular Bone Matrix - Fractures, Bone, Nonunion of Fracture | Recruiting | LifeNet Health | 250 | 2021-06-01 | 2026-09-15 | |
| Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial Cognitive Behavioural Therapy - Pain, Postoperative, Pain, Acute | Not applicable | Completed | McMaster University | 1024 | 2021-01-25 | 2025-09-05 |
| Impact of Psychoeducational Video on Adjustment to Open Fracture. Video Viewing - Major Trauma | Not applicable | Terminated | Oxford University Hospitals NHS Trust | 22 | 2020-12-03 | 2023-01-13 |
| Placement of Antibiotic Powder in Wounds During the Emergency Room Vancomycin - Open Fracture | Phase 4 | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2020-10-05 | 2026-09-30 |
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Fractures, Bone (11) · Fractures, Closed (9) · Surgical Wound Infection (7) · Tibial Fractures (7) · Wounds and Injuries (7) · Infections (5) · Pain, Postoperative (3) · Wound Infection (3) · Accidental Injuries (2) · Femoral Fractures (2) · Fractures, Ununited (2) · Acute Pain (1) · Chronic Pain (1) · Fibula Fractures (1)
Wounds and Injuries (36) · Fractures, Bone (32) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Postoperative Complications (10) · Leg Injuries (8) · Infections (6) · Wound Infection (4) · Neurologic Manifestations (3) · Pain (3) · Signs and Symptoms (3) · Musculoskeletal Diseases (2) · Craniocerebral Trauma (1) · Facial Injuries (1) · Femoral Fractures (1)
Vancomycin (5) · Therapeutics (4) · Cognitive Behavioral Therapy (3) · Tobramycin (3) · Cefazolin (2) · Ceftaroline (1) · Ceftriaxone (1) · Cephalexin (1) · Chromogranins (1) · Clindamycin (1) · Debridement (1) · DuraPrep (1) · Fracture Fixation, Internal (1) · Gentamicins (1) · Negative-Pressure Wound Therapy (1)
McMaster University (3) · Dartmouth-Hitchcock Medical Center (2) · Olayemi Osiyemi MD (2) · Oxford University Hospitals NHS Trust (2) · University of Maryland, Baltimore (2) · Aga Khan University (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Assiut University (1) · Atlantic Health System (1) · BONESUPPORT AB (1) · Emory University (1) · Hospices Civils de Lyon (1) · Inova Health Care Services (1) · Johns Hopkins University (1) · LifeNet Health (1)
United States (25) · Canada (6) · United Kingdom (3) · France (2) · Germany (2) · Israel (2) · China (1) · Egypt (1) · Italy (1) · Philippines (1) · Poland (1) · Spain (1) · Thailand (1)
Sheila Sprague, PhD (4) · Gerard Slobogean, MD (2) · Jason Busse, PhD (2) · Mohit Bhandari, MD (2) · Olayemi Osiyemi, MD (2) · Abraham Goch, MD (1) · Ali Mohamadean Mohamed, Professor (1) · Allison R Lauver, PharmD (1) · Arun Aneja, MD, PhD (1) · Boonsin Tangtrakulwanich, MD.,Ph.D (1) · Chad W Donley, MD (1) · David J Gemmel, PhD (1) · Dirk W Kiner, MD (1) · Douglas R. Dirschl, MD (1) · Erin Osborn (1)
PMID 32259266, PMID 32787892, PMID 33648577, PMID 36244384, PMID 36273187, PMID 36456987, PMID 37002119, PMID 38184642, PMID 38294973, PMID 39237277, PMID 39799376
1UG3AR085896 (1)