78 completed, 27 unknown, 16 recruiting, 15 terminated. 85 Not applicable, 13 Phase 4, 12 Phase 2, 3 Phase 1, 3 Phase 3.
Follow Total Knee Replacement: new trials by email Literature Review of Total Knee Replacement trials Research Report on Total Knee Replacement
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Dressing-related Experiences and Surgical Site Self-care in Hip and Knee Replacement: an Observational Cohort Study Wound Dressing Material - Total Hip Replacement, Total Knee Replacement | Recruiting | Bournemouth University | 100 | 2026-07-23 | 2026-08-24 | |
| Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Usual Care Group - Knee Osteoarthristis, Total Knee Replacement | Not applicable | Not yet recruiting | Ludwig Boltzmann Institute for Digital Health and Prevention | 60 | 2026-07-15 | 2026-07-14 |
| Circulatory Exercise After Total Knee Replacement standard postoperative TKR rehabilitation, Standard Rehabilitation Plus Circulatory Exercise - Total Knee Replacement, Knee Osteoarthritis | Not applicable | Not yet recruiting | Assiut University | 68 | 2026-06-16 | 2026-07-07 |
| In-Clinic Versus Tele-Rehabilitation in Women With Knee Osteoarthritis In-Clinic Rehabilitation, Tele-Rehabilitaion - Total Knee Replacement | Not applicable | Completed | Riphah International University | 26 | 2026-04-01 | 2026-06-17 |
| Binaural Beats for Postoperative Pain and Anxiety Reduction Binaural Beats Audio Intervention, Music of Choice - TKA, THA | Not applicable | Recruiting | University of Miami | 50 | 2026-03-09 | 2026-09-30 |
| Cooling of the Knee After Total Knee Arthroplasty Cool Down Liquid with Bandage ( CoolDown, CH), Ice package cooling system, Standard Postoperative Protocol Without Cooling - Osteoarthritis, Knee, Total Knee Replacement | Not applicable | Completed | Clinical Center of Vojvodina | 99 | 2026-03-01 | 2026-10-19 |
| The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty Weighted Blanket - Total Knee Replacement | Not applicable | Completed | NYU Langone Health | 30 | 2026-02-04 | 2026-08-28 |
| Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty Effect of two different drugs on post operative pain after TKA - Total Knee Replacement | Phase 1 / Phase 2 | Not yet recruiting | Abdelrahman Gaber Sayed Elkhateeb | 1 | 2026-01-13 | 2026-01-09 |
| Femoral Component TKA: Extramedullary vs Conventional Intramedullary Guide Total Knee Replacement | Recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 150 | 2025-10-15 | 2026-09-11 | |
| Mako Cementless TKA vs Mako Cemented TKA Mako cementless TKA, Mako cemented TKA - Total Knee Replacement, Total Knee Replacement Surgery | Not applicable | Recruiting | University College, London | 120 | 2025-09-29 | 2026-02-20 |
| Comparison of the Effects of Apixaban on Thrombin Generation in Patients With de Novo Multiple Myeloma Blood sampling, Apixaban - Multiple Myeloma, Total Knee Replacement | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 36 | 2025-09-15 | 2026-09-21 |
| Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement Physical Therapy Rehabilitation - Knee Osteoarthritis, Total Knee Replacement | Not applicable | Recruiting | Jouf University | 30 | 2025-08-15 | 2026-04-29 |
| An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool post op communication software - Total Hip Replacement, Total Knee Replacement | Completed | Concentra AI, inc | 652 | 2025-05-01 | 2026-08-31 | |
| Postural Correctors & Activity Trackers in Total Knee Replacement Rehab Activity Tracker & Postural Corrector, Conventional Therapy - Total Knee Replacement | Not applicable | Completed | Riphah International University | 20 | 2025-04-01 | 2026-02-25 |
| Efficacy of Kinesiotaping During Rehabilitation Following Total Knee Replacement Surgery Kinesiotaping (KT), Standard Rehabilitation - Total Knee Replacement, Postoperative Recovery | Not applicable | Active not recruiting | SRH Gesundheitszentrum Bad Herrenalb | 102 | 2025-02-08 | 2025-02-18 |
| The Effect of TENS on Early Patient Outcomes After Total Knee Arthroplasty TENS group - Total Knee Replacement | Not applicable | Enrolling by invitation | Cukurova University | 44 | 2024-12-01 | 2025-09-04 |
| Remote Multichannel Monitoring of Patients With Chronic DIseAses Using Speech technoLogies Based On Artificial intelliGence Voice assistant - Heart Failure, Diabetes Mellitus | Not applicable | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 500 | 2024-10-15 | 2024-10-16 |
| Comparative Effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in Patients With Total Knee Replacement. Instrument-assisted soft tissue mobilization, Cross Fibre Massage - Total Knee Replacement | Not applicable | Completed | Rashid Latif Medical College | 50 | 2024-08-15 | 2026-01-23 |
| The Effect of Abdominal Massage and Warm Application on Excretory Activity in Patients Undergoing Total Knee Replacement With Spinal Anesthesia abdominal massage andwarm application - Total Knee Replacement | Not applicable | Unknown | Ayşe Demirtaş | 84 | 2024-08-05 | 2024-08-30 |
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Osteoarthritis, Knee (17) · Pain (15) · Pain, Postoperative (12) · Osteoarthritis (9) · Musculoskeletal Diseases (4) · Anxiety Disorders (3) · Heart Failure (3) · Motor Activity (3) · Agnosia (2) · Pneumonia (2) · Pulmonary Disease, Chronic Obstructive (2) · Venous Thromboembolism (2) · Arthritis (1) · Chronic Pain (1) · Constipation (1)
Pathological Conditions, Signs and Symptoms (29) · Musculoskeletal Diseases (26) · Arthritis (25) · Joint Diseases (25) · Rheumatic Diseases (25) · Signs and Symptoms (23) · Neurologic Manifestations (22) · Osteoarthritis (17) · Pathologic Processes (17) · Postoperative Complications (12) · Pain (8) · Cardiovascular Diseases (7) · Vascular Diseases (6) · Behavior (5) · Embolism and Thrombosis (3)
Arthroplasty, Replacement, Knee (8) · Ropivacaine (6) · Bupivacaine (4) · Exercise (4) · Drug Delivery Systems (3) · Bandages (2) · Blood Specimen Collection (2) · Enoxaparin (2) · Fentanyl (2) · Gabapentin (2) · Interviews as Topic (2) · Levobupivacaine (2) · Morphine (2) · Acupuncture Therapy (1) · Anesthesia, Conduction (1)
Hadassah Medical Organization (4) · Hospital for Special Surgery, New York (4) · Riphah International University (4) · Assiut University (3) · Corin (3) · Limacorporate S.p.a (3) · Mayo Clinic (3) · Northwell Health (3) · Rothman Institute Orthopaedics (3) · SPR Therapeutics, Inc. (3) · I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio (2) · IRCCS San Raffaele Roma (2) · Istanbul University (2) · Medical University of South Carolina (2) · NHS Fife (2)
United States (44) · United Kingdom (12) · France (10) · Italy (9) · Turkey (Türkiye) (9) · Canada (6) · Israel (6) · Germany (5) · Pakistan (5) · Spain (4) · Australia (3) · Belgium (3) · Denmark (3) · Egypt (3) · Austria (2)
Ayesha Sadiq, MSPT (OMPT) (2) · Jinlei Li, MD PhD (2) · Marco Franceschini, MD (2) · Ahmed Abdel-Aal, prof. (1) · Ahsun Jiwani, MSc. Epibio (1) · Alexandra Sideris, PhD (1) · Amrik Singh, M.D. (1) · Andreas Veihelmann, MD, PhD (1) · Aristeidis Zibis, Medicine (1) · Artur Stolarczyk, MD, PhD (1) · Aruba Saeed, PhD* (1) · Athanasios Drakos, Medicine (1) · Blaine Price (1) · Brian Burnikel (1)
PMID 16434531, PMID 16624632, PMID 17129308, PMID 17894152, PMID 20234041, PMID 2025190, PMID 21697139, PMID 22049287, PMID 22588767, PMID 22676495, PMID 23479393, PMID 23573142, PMID 23932834, PMID 24674732, PMID 25772701, PMID 26261829, PMID 27333231, PMID 27555173, PMID 27863613, PMID 28070420, PMID 28089184, PMID 29357330, PMID 30640244, PMID 31389832, PMID 31604440, PMID 31879495, PMID 32049833, PMID 32167483, PMID 32308715, PMID 32985338, PMID 33004382, PMID 33185695, PMID 33352007, PMID 33401364, PMID 33401365, PMID 33423113, PMID 33496677, PMID 34196978, PMID 34261807, PMID 34308957, PMID 34430763, PMID 34619742, PMID 34820153, PMID 34839056, PMID 35189397, PMID 35857151, PMID 36058824, PMID 36171728, PMID 37486184, PMID 38049030
2014 (1), P01GM113852 (1), R01AG060920 (1), R01HL147155 (1)