6 completed, 2 recruiting, 2 unknown, 1 not yet recruiting. 12 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 6, Recruiting 2, Unknown 2, Not yet recruiting 1, Terminated 1 |
| Phase 1 | 3 | Completed 1, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Total Knee Replacement: new trials by email Literature Review of Total Knee Replacement trials Research Report on Total Knee Replacement
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty Effect of two different drugs on post operative pain after TKA - Total Knee Replacement | Phase 1 / Phase 2 | Not yet recruiting | Abdelrahman Gaber Sayed Elkhateeb | 1 | 2026-01-13 | 2026-01-09 |
| Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2 Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate - Total Knee Replacement, Knee Arthroplasty | Phase 2 | Recruiting | Yale University | 66 | 2023-02-07 | 2026-07-23 |
| Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate - Total Knee Replacement, Knee Arthroplasty | Phase 2 | Recruiting | Yale University | 250 | 2022-09-08 | 2026-07-23 |
| Adductor Canal Block Ropivacaine injection, Saline Injection, Total Knee Arthroplasty - Osteoarthritis, Total Knee Replacement | Phase 2 / Phase 3 | Terminated | OrthoCarolina Research Institute, Inc. | 93 | 2020-10-09 | 2026-04-06 |
| Efficacy and Safety of Chuna Manual Treatment as an Adjunctive Therapy After Total Knee Arthroplasty: A Study Protocol for a Single-Center, Randomized, Assessor Blind, Parallel-Group Clinical Trial Chuna + Usual care(Celecoxib and esomeprazole), Usual care(Celecoxib and esomeprazole) - Total Knee Replacement, Manipulation | Phase 2 | Completed | Gachon University Gil Oriental Medical Hospital | 22 | 2018-11-01 | 2021-07-08 |
| Safety and Activity of F14 for Management of Pain Following Total Knee Replacement Bupivacaine HCl, F14 (celecoxib) - Total Knee Replacement, Postoperative Pain | Phase 2 | Completed | Arthritis Innovation Corporation | 20 | 2018-05-04 | 2020-07-10 |
| Negative Pressure Wound Therapy -PREVENA in Prevention of Infections After Total Knee Arthroplasty (TKA) Negative Pressure Wound Therapy (NPWT), standard prophylactic therapy - Total Knee Replacement | Phase 2 | Unknown | Hadassah Medical Organization | 2014-06-01 | 2014-04-21 | |
| Safety and Efficacy of TeaRx Xa Factor Direct Inhibitor Versus Enoxaparin as a Venous Thromboembolic Events (VTE) Prevention Following Total Knee Replacement TeaRx, Enoxaparin - Total Knee Replacement | Phase 2 | Completed | TeaRx LLC | 200 | 2013-08-01 | 2017-03-23 |
| Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring - COGNIDES Intraoperative anesthetic strategy by Propofol, Intraoperative anesthetic strategy by Desflurane - Orthopedic Surgery, Total Hip Prosthesis | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 60 | 2013-04-01 | 2014-12-23 |
| Femoral Block With or Without Ropivacaine for Analgesia After Total Knee Replacement (TKR) Ropivacaine - Total Knee Replacement | Phase 1 / Phase 2 | Completed | Hopital de l'Enfant-Jesus | 80 | 2006-04-01 | 2011-02-28 |
| Static and Dynamic Balance in Correlation With Quality of Life, in Primary Total Knee Replacement total knee replacement - Osteoarthritis, Total Knee Replacement | Phase 1 / Phase 2 | Unknown | Hadassah Medical Organization | 150 | 2005-11-01 | 2008-05-13 |
| New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery LY517717, enoxaparin - Total Knee Replacement, Total Hip Replacement | Phase 2 | Completed | Eli Lilly and Company | 511 | 2003-12-01 | 2008-03-31 |
Osteoarthritis (2) · Pain, Postoperative (2) · Pain (1)
Arthritis (2) · Joint Diseases (2) · Musculoskeletal Diseases (2) · Neurologic Manifestations (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Postoperative Complications (2) · Rheumatic Diseases (2) · Signs and Symptoms (2) · Pain (1)
Arthroplasty, Replacement, Knee (2) · Enoxaparin (2) · Ropivacaine (2) · Bupivacaine (1) · Celecoxib (1) · Esomeprazole (1) · LY517717 (1) · Negative-Pressure Wound Therapy (1) · Sodium Chloride (1)
Hadassah Medical Organization (2) · Yale University (2) · Abdelrahman Gaber Sayed Elkhateeb (1) · Arthritis Innovation Corporation (1) · Assistance Publique - Hôpitaux de Paris (1) · Eli Lilly and Company (1) · Gachon University Gil Oriental Medical Hospital (1) · Hopital de l'Enfant-Jesus (1) · OrthoCarolina Research Institute, Inc. (1) · TeaRx LLC (1)
United States (4) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · Czechia (1) · Egypt (1) · France (1) · Germany (1) · Hungary (1) · Israel (1) · Italy (1) · Poland (1) · Russia (1) · South Korea (1)
Jinlei Li, MD PhD (2) · Bryan D Springer, MD (1) · Cyrille Robert, PH (1) · Isabella Schwartz, MD (1) · Jared Foran, MD (1) · Mikhail N. Zamyatin, Prof. (1) · Yun Kyung Song, PhD (1)