35 completed, 14 unknown, 3 not yet recruiting, 2 recruiting. 38 Not applicable, 10 Phase 4, 6 Phase 3, 5 Phase 2, 1 Phase 1.
Follow Symptomatic Irreversible Pulpitis: new trials by email Literature Review of Symptomatic Irreversible Pulpitis trials Research Report on Symptomatic Irreversible Pulpitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Different Root Canal Filling Materials and Irrigation Agitation Techniques on Postoperative Pain in Teeth With Irreversible Pulpitis: A Randomized Clinical Trial XP-Endo Finisher, EDDY, Passive Ultrasonic Activation - Postoperative Pain After Endodontic Treatment, Oral Health-Related Quality of Life | Not applicable | Not yet recruiting | Ankara University | 324 | 2026-11-13 | 2026-10-05 |
| This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. Endo-ice (Refrigerant Spray), Ice-sticks - Root Canal Treatment, Intra-operative Pain | Not applicable | Not yet recruiting | Dow University of Health Sciences | 90 | 2026-09-15 | 2026-08-25 |
| Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment dexamethasone, Saline (0.9% NaCl) - Symptomatic Irreversible Pulpitis | Phase 4 | Not yet recruiting | Watim Medical & Dental College | 60 | 2026-08-01 | 2026-08-24 |
| Effect of Preoperative Video-Guided Breathing on Pain in Symptomatic Irreversible Pulpitis Video-Guided Breathing Exercise - Symptomatic Irreversible Pulpitis, Postoperative Pain | Not applicable | Completed | Cukurova University | 90 | 2026-05-09 | 2026-10-19 |
| Comparison of Postoperative Pain After Root Canal Irrigation in Symptomatic Irreversible Pulpitis Dexamethasone, Sodium Chloride 0.9% - Symptomatic Irreversible Pulpitis | Not applicable | Completed | CMH Lahore Medical College and Institute of Dentistry | 72 | 2026-02-28 | 2026-10-22 |
| Postoperative Pain After Root Canal Obturation Using Bioceramic and Calcium Hydroxide Sealers CeraSeal Bioceramic Sealer, Sealapex Calcium Hydroxide Sealer - Symptomatic Irreversible Pulpitis | Not applicable | Recruiting | HITEC-Institute of Medical Sciences | 50 | 2026-01-01 | 2026-02-17 |
| Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic Vital Pulp Therapy, Root Canal Treatment - Symptomatic Irreversible Pulpitis | Not applicable | Active not recruiting | Ain Shams University | 34 | 2025-11-15 | 2026-04-24 |
| Comparison of WaveOne and ProTaper Systems on Postoperative Pain in Irreversible Pulpitis Patients WaveOne Reciprocating System, ProTaper Rotary System - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Armed Forces Institute of Dentistry, Pakistan | 146 | 2025-08-11 | 2026-04-03 |
| The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain Trypsin, Bromelain and Rutoside, Diclofenac Potassium 50mg Tab, Prednisolone Oral Tablet - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Cairo University | 124 | 2025-06-15 | 2026-07-22 |
| To COMPARE the EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS UNDERGOING ROOT CANAL TREATMENT in TEETH with IRREVERSIBLE PULPITIS Rotary Crown Down Technique, Manual Step Back Technique - Irreversible Pulpitis, Symptomatic Irreversible Pulpitis | Not applicable | Unknown | Urooj Fatima | 70 | 2025-05-01 | 2025-02-24 |
| Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy Calcium Silicate Cement, Er,Cr:YSGG Laser - Symptomatic Irreversible Pulpitis, Symptomatic Irreversible Pulpitis (SIP) | Not applicable | Completed | University of Fujairah | 46 | 2025-04-24 | 2026-07-22 |
| The Effect of XP-Endo Finisher Activation of Bioceramic Sealer on Postoperative Pain in Mandibular First Molar With Symptomatic Irreversible Pulpitis sealer activation after cleaning and shaping with XP-Endo Finisher, negative control where canals are obturated directly without sealer activation - Symptomatic Irreversible Pulpitis | Not applicable | Recruiting | Future University in Egypt | 30 | 2024-11-01 | 2025-06-29 |
| Comparison of Post-Operative Pain Occurrence After Single Visit Root Canal Treatment single visit root canal treatment using ProTaper Universal rotary system, single visit root canal treatment using M-Pro rotary system - Symptomatic Irreversible Pulpitis | Not applicable | Enrolling by invitation | National Research Centre, Egypt | 80 | 2024-10-25 | 2025-01-15 |
| Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis regenerative endodontic therapy using I-PRF, blood clot - Symptomatic Irreversible Pulpitis | Not applicable | Unknown | Shaheed Zulfiqar Ali Bhutto Medical University | 60 | 2024-08-01 | 2024-08-05 |
| Evaluation of Success of Complete Pulpotomy With Biodentine on Mature Permanent Single Rooted Teeth With Symptomatic Irreversible Pulpitis Complete Pulpotomy with Biodentine - Symptomatic Irreversible Pulpitis | Not applicable | Completed | HITEC-Institute of Medical Sciences | 40 | 2024-07-02 | 2025-08-08 |
| Comparative Evaluation of Postoperative Pain and Clinical Success Root canal preparation with Hand Files (Dentsply Sirona), Root canal preparation with the WaveOne Gold file system (Dentsply Sirona, Ballaigues, Switzerland), Root canal preparation with the ProTaper Ultimate file system (Dentsply Sirona) - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Ege University | 63 | 2024-06-11 | 2025-08-20 |
| Comparison of Anesthetic Efficacy of Mental Nerve Block Versus Inferior Alveolar Nerve Block in Mandibular Anterior Teeth and Premolars in Symptomatic Irreversible Pulpitis inferior alveolar nerve block, mental nerve block - Symptomatic Irreversible Pulpitis | Not applicable | Unknown | Prime Foundation | 96 | 2024-04-01 | 2024-03-27 |
| Effect of Dental Anxiety on Mandibular Anesthesia Success Standardized Mandibular Anesthesia Protocol - Dental Anxiety, Symptomatic Irreversible Pulpitis | Not applicable | Completed | Kutahya Health Sciences University | 52 | 2023-12-15 | 2025-08-15 |
| Combination of Buffered Anesthetic to Treat Mandibular Molars Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi - Symptomatic Irreversible Pulpitis | Phase 4 | Terminated | Indiana University | 40 | 2023-12-05 | 2025-05-13 |
| Anesthetic Efficacy of 1.8 ml Versus 3.6 ml of 4% Articaine Buccal Infiltration 3.6 ml 4% Articaine hydrochloride, 1.8 ml 4% Articaine hydrochloride - Symptomatic Irreversible Pulpitis | Not applicable | Unknown | Cairo University | 70 | 2023-12-01 | 2023-11-07 |
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Pain, Postoperative (16) · Pain (4) · Pulpitis (3) · Dental Pulp Diseases (1) · Periapical Periodontitis (1)
Neurologic Manifestations (20) · Pathological Conditions, Signs and Symptoms (20) · Signs and Symptoms (20) · Pain (16) · Pathologic Processes (16) · Postoperative Complications (16) · Stomatognathic Diseases (5) · Tooth Diseases (4) · Dental Pulp Diseases (3) · Jaw Diseases (1) · Mouth Diseases (1) · Periapical Diseases (1) · Periodontal Diseases (1) · Periodontitis (1)
Carticaine (5) · Diclofenac (4) · Epinephrine (4) · Ibuprofen (4) · Mepivacaine (4) · Tramadol (4) · Dexamethasone (3) · Lidocaine (3) · Acetaminophen (2) · Cryotherapy (2) · Ketorolac (2) · Prednisolone (2) · Saline Solution (2) · Sodium Chloride (2) · Tablets (2)
Cairo University (19) · Dow University of Health Sciences (3) · Alfarabi Colleges (2) · Altamash Institute of Dental Medicine (2) · HITEC-Institute of Medical Sciences (2) · Indiana University (2) · 28 Military Dental Centre Lahore (1) · Ain Shams University (1) · Ankara University (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Azad University of Medical Sciences (1) · CMH Lahore Medical College and Institute of Dentistry (1) · Cukurova University (1) · Cumhuriyet University (1) · Daniel Chavarría Bolaños (1)
Pakistan (15) · Egypt (12) · Turkey (Türkiye) (6) · United States (4) · Saudi Arabia (3) · Iran (2) · Mexico (2) · United Arab Emirates (1)
Amr M Elnaghy, PhD (2) · Farah Naz, BDS FCPS (2) · Tayyaba Tahira, BDS FCPS (2) · Abeer Elgendy, Professor (1) · Ahmed A Soliman, MSc (1) · Ahmed S Elsheshtawy (1) · Aisha Wali, BDS, MPH (1) · Alaa M. Morsi (1) · Amaury Pozos, MSc, PhD (1) · Avina Paranjpe (1) · Brian Judd, DDS (1) · Daniel Chavarria, MSc, PhD (1) · David Bingham, DDS (1) · Dr Shahbaz Saqib, BDS (1)
PMID 10195537, PMID 15041620, PMID 15502049, PMID 15804720, PMID 17052637, PMID 17656294, PMID 20340056, PMID 21217614, PMID 21555171, PMID 21692235, PMID 22981094, PMID 25598754, PMID 27248848, PMID 27641947, PMID 37092958, PMID 37920592, PMID 38925367, PMID 41413418, PMID 41952147, PMID 42473278