10 completed, 10 recruiting, 6 terminated, 6 withdrawn. 39 Phase 2, 9 Phase 3, 4 Phase 1.
Follow Suicidal Ideation: new trials by email Literature Review of Suicidal Ideation trials Research Report on Suicidal Ideation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay Esketamine, Midazolam (Intravenous) - Suicidal Ideation, Suicidal Behavior | Phase 2 | Not yet recruiting | University of Sao Paulo | 106 | 2027-04-30 | 2026-10-22 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency Department Ketamine Injectable Solution, Placebo Injection, Crisis Response Plan - Suicidal Ideation | Phase 2 | Recruiting | The University of Texas Health Science Center at San Antonio | 200 | 2026-09-30 | 2026-10-15 |
| Inhaled DMT for Major Depressive Disorder N,N-Dimethyltryptamine (15 mg + 60 mg), N,N-Dimethyltryptamine (1 mg + 4 mg) - MDD, Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Universidade Federal do Rio Grande do Norte | 140 | 2026-08-01 | 2026-07-13 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies fMRI Neurofeedback, Accelerated theta burst stimulation, Psilocybin assisted therapy - Suicidal Ideation | Phase 2 | Withdrawn | University of New Mexico | 2026-05-01 | 2026-03-20 | |
| Sleep Health in U.S. Marines Sleep Leadership, Circadian, Light, and Sleep Skills in Shipboard Military (CLASS-MC) Personnel Program, Insomnia Coach - Depression, Suicidality | Phase 2 | Recruiting | San Diego State University | 860 | 2026-03-31 | 2026-04-16 |
| N2O for Acute Suicidality and Depression in the ED Nitrous oxide gas for inhalation, Placebo - Suicidal Ideation, Major Depressive Disorder | Phase 2 | Withdrawn | University of Chicago | 2026-02-27 | 2026-03-04 | |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality Psilocybin, Therapeutic Support - Bipolar II Disorder, Depression, Bipolar | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 10 | 2025-07-07 | 2026-08-12 |
| Understanding and Treating Suicidal Ideation With Ketamine ketamine hydrochloride - Suicidal Ideation, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 36 | 2025-04-08 | 2026-11-09 |
| Nitrous Oxide in the Treatment of Acute Suicidal Ideation 50% N2O plus 50% O2, Oxygen (O2) - Suicidality, EEG | Phase 2 | Recruiting | University of Zurich | 85 | 2025-01-13 | 2025-01-16 |
| Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral) - Suicidal Ideation, Major Depressive Disorder | Phase 2 / Phase 3 | Active not recruiting | Michigan State University | 30 | 2024-07-03 | 2026-11-02 |
| SAINT for MDD in an Inpatient Setting Follow-on Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| Ketamine for OUD and Suicidal Ideation in the ED Ketamine, Saline Solution - Opioid Use Disorder, Suicidal Ideation | Phase 2 | Terminated | Brigham and Women's Hospital | 4 | 2024-06-14 | 2025-04-08 |
| Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide Nitrous oxide, Medical air - Suicidal Ideation, Emergency Psychiatric | Phase 2 | Unknown | University Hospital, Tours | 30 | 2024-06-01 | 2024-06-07 |
| iTBS+D-Cycloserine for Youth Suicide D-Cycloserine, intermittent Theta-Burst-repetitive Transcranial Magnetic Stimulation, Placebo oral tablet - Suicidal Ideation, Suicide, Attempted | Phase 2 | Recruiting | University of Calgary | 54 | 2024-03-11 | 2024-11-12 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects Perampanel 6 MG, Ketamine, Placebo - Depressive Disorder, Major Depressive Disorder | Phase 2 | Recruiting | Yale University | 30 | 2023-04-03 | 2026-05-06 |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the ED Ketamine Hydrochloride, Crisis Response Plan - Suicide | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center at San Antonio | 24 | 2023-01-06 | 2026-09-30 |
| Ketamine Infusion for Rapid Reduction of Suicidality in Pediatrics Ketamine Injectable Solution, Midazolam Injectable Solution, Normal Saline 0.9% Injectable Solution - Suicidal Ideation | Phase 1 / Phase 2 | Terminated | University of British Columbia | 15 | 2022-06-01 | 2024-12-18 |
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Depression (16) · Depressive Disorder, Major (13) · Suicide (10) · Bipolar Disorder (8) · Suicide, Attempted (5) · Depressive Disorder, Treatment-Resistant (3) · Emergencies (3) · Stress Disorders, Post-Traumatic (3) · Depressive Disorder (2) · Mental Disorders (2) · Mood Disorders (2) · Self-Injurious Behavior (2) · Anxiety Disorders (1) · Behavior (1)
Behavior (38) · Behavioral Symptoms (38) · Self-Injurious Behavior (37) · Suicide (29) · Mental Disorders (20) · Mood Disorders (16) · Depressive Disorder (11) · Bipolar and Related Disorders (8) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Chemically-Induced Disorders (2) · Narcotic-Related Disorders (1)
Ketamine (12) · Lurasidone Hydrochloride (3) · Midazolam (3) · Psilocybin (3) · Cycloserine (2) · Nitrous Oxide (2) · Saline Solution (2) · Therapeutics (2) · Air (1) · Endothelium-Dependent Relaxing Factors (1) · Esketamine (1) · Inhalation (1) · Injections (1) · Light (1) · Music Therapy (1)
NeuroRx, Inc. (3) · Magnus Medical (2) · The University of Texas Health Science Center at San Antonio (2) · The University of Texas Health Science Center, Houston (2) · University of New Mexico (2) · Boston Children's Hospital (1) · Brigham and Women's Hospital (1) · Icahn School of Medicine at Mount Sinai (1) · Joshua Rosenblat (1) · Marijn Lijffijt, PhD (1) · Michigan State University (1) · New York State Psychiatric Institute (1) · Novartis Pharmaceuticals (1) · Oui Therapeutics, Inc. (1) · San Diego State University (1)
United States (27) · Canada (5) · Brazil (3) · Argentina (1) · China (1) · France (1) · Germany (1) · Japan (1) · Malaysia (1) · Mexico (1) · Netherlands (1) · Poland (1) · Russia (1) · Spain (1) · Switzerland (1)
Brandon Bentzley, MD (2) · Aimee Moulin, MD (1) · Alan Peterson, PhD, ABPP (1) · Alexander McGirr, MD PhD (1) · Andrew A Nierenberg, MD (1) · Andrew Nierenberg, MD (1) · Cheryl McCullumsmith, MD PhD (1) · Daniel C Javitt, MD (1) · Davin Quinn, MD (1) · Emily Schmied, PhD (1) · Jennifer Phillips, PhD (1) · John R Knight, MD (1) · Jonathan C Javitt, MD, MPH (1)
PMID 29202655, PMID 32785636, PMID 33318635, PMID 33583341, PMID 33825765, PMID 34149476, PMID 35110300, PMID 35735167, PMID 36776623, PMID 37573534, PMID 39714786, PMID 39915491, PMID 40669910, PMID 40779267, PMID 41545765, PMID 42138588, PMID 42234079, PMID 42442821, PMID 42477489
KL2TR003168 (1), R01MH107183 (1), R01MH125160 (1), R42MH123357 (1), UL1TR002645 (1)