10 completed, 9 unknown, 3 recruiting, 3 terminated. 28 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 10, Unknown 9, Recruiting 3, Terminated 3, Withdrawn 2, Active not recruiting 1 |
| Phase 2 | 9 | Terminated 3, Completed 2, Recruiting 2, Active not recruiting 1, Unknown 1 |
Follow Suicidal Ideation: new trials by email Literature Review of Suicidal Ideation trials Research Report on Suicidal Ideation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding and Treating Suicidal Ideation With Ketamine ketamine hydrochloride - Suicidal Ideation, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 36 | 2025-04-08 | 2026-11-09 |
| Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral) - Suicidal Ideation, Major Depressive Disorder | Phase 2 / Phase 3 | Active not recruiting | Michigan State University | 30 | 2024-07-03 | 2026-11-02 |
| SAINT for MDD in an Inpatient Setting Follow-on Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation Ketamine Hydrochloride, Normal saline - Suicidal Ideation | Phase 3 | Unknown | University of Ottawa | 20 | 2023-06-01 | 2023-02-13 |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the ED Ketamine Hydrochloride, Crisis Response Plan - Suicide | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center at San Antonio | 24 | 2023-01-06 | 2026-09-30 |
| Anti-suicidal Effects of Buprenorphine In Depressed Individuals Belbuca Buccal Product, Placebo - Suicidal Ideation, Major Depressive Disorder | Phase 3 | Withdrawn | New York State Psychiatric Institute | 2022-10-10 | 2023-11-14 | |
| Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents Ketamine Hydrochloride, Midazolam Hydrochloride - Suicide, Attempted, Suicide and Depression | Phase 3 | Completed | University of Texas Southwestern Medical Center | 50 | 2022-10-03 | 2026-10-15 |
| NRX-101 for Bipolar Depression With Subacute Suicidal Ideation NRX-101, Lurasidone HCl - Bipolar Depression, Suicidal Ideation and Behavior | Phase 2 / Phase 3 | Completed | NeuroRx, Inc. | 74 | 2022-05-12 | 2024-05-08 |
| A Study to Evaluate the Safety and Effectiveness of a Digital Therapeutic OTX-202, OTX-000, Treatment as Usual - Suicide, Attempted, Suicidal Ideation | Phase 2 / Phase 3 | Terminated | Oui Therapeutics, Inc. | 356 | 2022-04-07 | 2025-06-12 |
| Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode Buprenorphine, Placebo - Suicidal Ideation, Major Depressive Episode | Phase 3 | Recruiting | Centre Hospitalier Universitaire de Nīmes | 180 | 2021-10-10 | 2025-08-21 |
| Transcendental Meditation and PTSD TM, PCT - Ptsd, Depressive Symptoms | Phase 3 | Unknown | David Lynch Foundation | 450 | 2021-10-01 | 2021-04-22 |
| NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation NRX-101, Lurasidone HCl - Bipolar Depression, Suicidal Ideation | Phase 3 | Unknown | NeuroRx, Inc. | 72 | 2019-12-01 | 2024-01-19 |
| NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression Ketamine Hydrochloride, Placebo - Bipolar Depression, Suicidal Ideation | Phase 3 | Unknown | NeuroRx, Inc. | 150 | 2019-06-25 | 2024-01-19 |
| NRX101 Glx Biomarker Validation Study NRX-101, Lurasidone HCl, Placebo - Bipolar Depression, Suicidal Ideation | Phase 2 / Phase 3 | Completed | NeuroRx, Inc. | 8 | 2018-11-01 | 2022-08-09 |
| Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse Intranasal ketamine, Placebo - Suicidal Ideation, Depression | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 33 | 2018-05-01 | 2023-03-01 |
| The Omega-3 Fatty Acid Paediatric Depression Trial Omega 3 fatty acid, Placebo oil - Depression | Phase 3 | Completed | Gregor Berger | 257 | 2017-04-28 | 2023-04-06 |
| The Impact of Ketamine on the Reward Circuitry of Suicidal Patients Ketamine Hydrochloride - Suicidal Ideation, Suicide | Phase 3 | Withdrawn | Massachusetts General Hospital | 2017-02-01 | 2017-03-03 | |
| Emergency Ketamine Treatment of Suicidal Ideation Intranasal Ketamine, Intranasal Saline Placebo - Depression, Suicidal Ideation | Phase 2 / Phase 3 | Unknown | University of Cincinnati | 60 | 2016-08-01 | 2016-08-05 |
| Effects of Ketamine in the Acute Phase of Suicidal Ideation Baseline evaluation, 1st perfusion of ketamine, 1st perfusion of saline - Suicidal Ideation | Phase 3 | Completed | Centre Hospitalier Universitaire de Nīmes | 156 | 2015-04-01 | 2025-12-01 |
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Depression (14) · Depressive Disorder, Major (7) · Bipolar Disorder (5) · Suicide (4) · Emergencies (3) · Stress Disorders, Post-Traumatic (3) · Suicide, Attempted (2) · Alcohol Drinking (1) · Alcoholism (1) · Behavior (1) · Brain Injuries, Traumatic (1) · Psychotic Disorders (1)
Behavioral Symptoms (28) · Self-Injurious Behavior (28) · Behavior (27) · Suicide (24) · Mental Disorders (15) · Mood Disorders (11) · Depressive Disorder (7) · Bipolar and Related Disorders (5) · Disease Attributes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Alcohol-Related Disorders (1) · Brain Diseases (1)
Ketamine (8) · Lurasidone Hydrochloride (3) · Buprenorphine (2) · Sodium Chloride (2) · Docosahexaenoic Acids (1) · Eicosapentaenoic Acid (1) · Fatty Acids, Omega-3 (1) · Meditation (1) · Midazolam (1) · Risperidone (1) · Saline Solution (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1)
NeuroRx, Inc. (4) · Centre Hospitalier Universitaire de Nīmes (2) · Magnus Medical (2) · Abarbanel Mental Health Center (1) · Augusta University (1) · Brown University (1) · David Lynch Foundation (1) · Gregor Berger (1) · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium (1) · Massachusetts General Hospital (1) · Michigan State University (1) · New York State Psychiatric Institute (1) · Oui Therapeutics, Inc. (1) · Prof. Yoram Yovell (1) · Tel-Aviv Sourasky Medical Center (1)
United States (18) · Israel (3) · Canada (2) · France (2) · Sri Lanka (1) · Switzerland (1)
Martin Brecher, MD (3) · Brandon Bentzley, MD (2) · Alan Peterson, PhD, ABPP (1) · Andrew A Nierenberg, MD (1) · Brigitte Rockstroh, Prof Dr (1) · Cheryl McCullumsmith, MD PhD (1) · Dawn Ionescu, M.D. (1) · Elisabeth Schauer, MA/MPH (1) · Fabrice Jollant, MD (1) · Jack Asherov, MD (1) · Jeffrey M Miller, MD (1) · Jennifer E. Johnson, Ph.D. (1) · Jennifer Phillips, PhD (1) · Jonathan C Javitt, MD, MPH (1) · Joshua T Kantrowicz, MD (1)
PMID 18681749, PMID 24731434, PMID 30246667, PMID 30714749, PMID 30857489, PMID 31035665, PMID 31827448, PMID 32785636, PMID 33215889, PMID 33583341, PMID 33884617, PMID 34149476, PMID 35110300, PMID 37425294, PMID 38696221, PMID 38743716, PMID 38969374, PMID 39714786, PMID 40061518, PMID 40779267, PMID 40894517, PMID 41481294, PMID 42849709
2014 (1), 2016 (1), R01MH095230 (1), R01MH125160 (1), R01MH125181 (1), R42MH123357 (1), UL1TR002645 (1)