17 completed, 6 unknown, 5 recruiting, 4 terminated. 36 Phase 3, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 36 | Completed 17, Unknown 6, Recruiting 5, Terminated 4, Withdrawn 2, Not yet recruiting 1, Suspended 1 |
| Phase 2 | 11 | Completed 6, Terminated 2, Unknown 2, Suspended 1 |
Follow Stroke, Acute: new trials by email Literature Review of Stroke, Acute trials Research Report on Stroke, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Normobaric Hyperoxia With Extended-Window Endovascular Therapy for Acute Ischemic Stroke (OPENS-EXTEND) Oxygen (Normobaric Hyperoxia), Sham Normobaric Hyperoxia, Endovascular Therapy - Stroke, Acute, Neuroprotection | Phase 3 | Not yet recruiting | Weifang Medical University | 314 | 2026-09-01 | 2026-07-21 |
| HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) Tirofiban, dual antiplatelet therapy - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | Weifang Medical University | 458 | 2026-06-22 | 2026-06-25 |
| Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke Tenecteplase, Alteplase - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 850 | 2025-12-25 | 2026-04-09 |
| Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine Peripheral intravenous norepinephrine - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | University Hospital, Bordeaux | 358 | 2024-11-28 | 2025-01-09 |
| CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2). Intraarterial alteplase - Stroke, Acute Ischemic, Stroke, Acute | Phase 3 | Completed | Hospital Clinic of Barcelona | 440 | 2023-11-18 | 2026-09-18 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Earlier Mobilization Post Acute Thrombolysis Mobilization - Stroke, Stroke, Acute | Phase 3 | Withdrawn | Brian Silver | 2023-08-01 | 2023-10-30 | |
| Earlier Mobilization Post Acute Thrombectomy Mobilization - Stroke, Stroke, Acute | Phase 3 | Withdrawn | Brian Silver | 2023-08-01 | 2023-10-30 | |
| PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE) Propranolol Hydrochloride, control group - Stroke, Vascular Accident | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 168 | 2023-02-21 | 2025-07-14 |
| Best Solution Identification to Prevent Hyperchloremia Combinations of Sodium Chloride and Sodium Acetate IV Fluids Along With Standard of Care Treatment in Acute Stroke Patients Sodium Chloride 0.9% infusion alone or in combination with Sodim acetate with normal saline in a ratio 1;1, 2;1 and 3;1 - Stroke, Acute | Phase 2 / Phase 3 | Unknown | Aga Khan University | 80 | 2023-02-01 | 2023-05-22 |
| Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study Glenzocimab, Placebo - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 108 | 2023-01-03 | 2026-07-08 |
| Carotid Artery Stenting During Endovascular Treatment of Acute Stroke carotid artery stenting during EVT, no carotid artery stenting during EVT - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | University Medical Center Groningen | 600 | 2022-11-15 | 2024-07-19 |
| Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke Tenecteplase, Placebo - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Hospital Moinhos de Vento | 398 | 2022-05-27 | 2025-04-04 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| SPT-07A Injection in Patients With Acute Ischemic Stroke (AIS): A Phase III Clinical Trial SPT-07A injection, placebo - Stroke, Acute | Phase 3 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 1112 | 2022-01-20 | 2023-04-28 |
| Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke Clevidipine - Stroke, Acute, Blood Pressure | Phase 3 | Completed | ProMedica Health System | 80 | 2021-10-30 | 2025-01-07 |
| Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke. Cerebrolysin - Stroke, Ischemic, Stroke, Acute | Phase 3 | Unknown | Military Institute od Medicine National Research Institute | 50 | 2021-01-01 | 2022-08-24 |
| Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis Placebo, Nerinetide - Stroke, Acute | Phase 3 | Completed | NoNO Inc. | 850 | 2020-12-06 | 2025-06-22 |
| Intensive Ambulance-delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial urapidil - Stroke, Acute, Cerebrovascular Disorders | Phase 3 | Completed | The George Institute for Global Health, China | 2425 | 2020-03-20 | 2025-03-26 |
| Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke Tenecteplase, Alteplase - Stroke, Acute, Thromboses, Intracranial | Phase 3 | Completed | University of Calgary | 1600 | 2019-12-10 | 2023-05-12 |
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Stroke (36) · Ischemic Stroke (17) · Cerebrovascular Disorders (6) · Brain Diseases (4) · Ischemia (4) · Cerebral Infarction (3) · Brain Ischemia (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Hemorrhagic Stroke (2) · Hypothermia (2) · Intracranial Thrombosis (2) · Vascular Diseases (2) · Body Temperature Changes (1) · Brain Edema (1)
Nervous System Diseases (35) · Cardiovascular Diseases (34) · Central Nervous System Diseases (34) · Vascular Diseases (34) · Brain Diseases (32) · Cerebrovascular Disorders (30) · Pathological Conditions, Signs and Symptoms (12) · Pathologic Processes (10) · Necrosis (5) · Infarction (4) · Ischemia (4) · Brain Infarction (3) · Brain Ischemia (3) · Signs and Symptoms (3) · Embolism and Thrombosis (2)
Tenecteplase (7) · Tissue Plasminogen Activator (3) · Aspirin (2) · Clopidogrel (2) · Saline Solution (2) · TNK-tissue plasminogen activator (2) · Control Groups (1) · Cool-Down Exercise (1) · Dapsone (1) · Ginkgo biloba extract (1) · Glyburide (1) · Minocycline (1) · Oxygen (1) · Phenylephrine (1) · Propranolol (1)
Brian Silver (2) · Hospital Clinic of Barcelona (2) · NoNO Inc. (2) · University of Calgary (2) · Weifang Medical University (2) · Aga Khan University (1) · Assistance Publique - Hôpitaux de Paris (1) · AstraZeneca (1) · Beijing Tiantan Hospital (1) · Capital Medical University (1) · Cidat, S.A. de C.V. (1) · Forest Laboratories (1) · Haukeland University Hospital (1) · Healios K.K. (1) · Hospital Moinhos de Vento (1)
China (9) · United States (9) · Canada (7) · Australia (6) · Germany (6) · Spain (6) · Switzerland (5) · United Kingdom (5) · Austria (4) · Brazil (4) · Finland (4) · France (4) · South Korea (4) · Czechia (3) · Netherlands (3)
Angel Chamorro, MD, PhD (2) · Brian Silver, MD (2) · Pol Camps, MD (2) · Raul G Nogueira, MD (2) · Ana Morales, MD (1) · Anil Gulati, MD, PhD (1) · Anna Ramos, MD (1) · Bijoy K Menon, MD (1) · Bo Hu, Dr. or PhD. (1) · Craig Anderson (1) · Elisa Cuadrado, MD, PhD (1) · Ellisiv B Mathiesen (1)
PMID 17509235, PMID 17687131, PMID 19097942, PMID 19834012, PMID 21852153, PMID 22474060, PMID 22738918, PMID 26387127, PMID 27834742, PMID 29134924, PMID 31645472, PMID 32087818, PMID 33428177, PMID 33446083, PMID 33464335, PMID 34872617, PMID 35143603, PMID 35525250, PMID 35590386, PMID 35779553, PMID 36549308, PMID 37082967, PMID 37165867, PMID 37449423, PMID 37800372, PMID 37830342, PMID 38124205, PMID 38165335, PMID 38174568, PMID 38227308, PMID 38272571, PMID 38275116, PMID 38676572, PMID 38752650, PMID 38768626, PMID 39236681, PMID 39379314, PMID 39435713, PMID 39542995, PMID 39577921, PMID 39648909, PMID 39955119, PMID 39957001, PMID 40122606, PMID 40123483, PMID 40325343, PMID 40396577, PMID 40541207, PMID 40677228, PMID 40866207
2014 (1), 2017 (1), 2018 (1), 2023 (1), P50NS044148 (1), P50NS044227 (1)