20 completed, 7 terminated, 2 unknown, 1 enrolling by invitation. 31 Phase 2, 11 Phase 3, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 31 | Completed 20, Terminated 7, Unknown 2, Enrolling by invitation 1, Suspended 1 |
| Phase 3 | 11 | Completed 6, Terminated 2, Unknown 2, Suspended 1 |
| Phase 1 | 5 | Completed 4, Terminated 1 |
Follow Stroke, Acute: new trials by email Literature Review of Stroke, Acute trials Research Report on Stroke, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care Remote ischemic conditioning (RIC) progammable device - Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease | Phase 2 | Enrolling by invitation | University of Calgary | 24 | 2024-12-01 | 2024-12-31 |
| Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion Direct Ischemic Post-conditioning, Endovascular therapy - Stroke, Acute, Neuroprotection | Phase 2 | Completed | Tianjin Huanhu Hospital | 60 | 2024-09-12 | 2026-06-15 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies Semaglutide - Stroke, Stroke, Acute | Phase 2 | Completed | Chinese University of Hong Kong | 140 | 2023-08-01 | 2025-03-07 |
| PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE) Propranolol Hydrochloride, control group - Stroke, Vascular Accident | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 168 | 2023-02-21 | 2025-07-14 |
| Best Solution Identification to Prevent Hyperchloremia Combinations of Sodium Chloride and Sodium Acetate IV Fluids Along With Standard of Care Treatment in Acute Stroke Patients Sodium Chloride 0.9% infusion alone or in combination with Sodim acetate with normal saline in a ratio 1;1, 2;1 and 3;1 - Stroke, Acute | Phase 2 / Phase 3 | Unknown | Aga Khan University | 80 | 2023-02-01 | 2023-05-22 |
| Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study Glenzocimab, Placebo - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 108 | 2023-01-03 | 2026-07-08 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism Lactate, Placebo - Stroke, Acute | Phase 2 | Terminated | Centre Hospitalier Universitaire Vaudois | 28 | 2021-08-05 | 2025-04-17 |
| Normobaric Hyperoxia Combined With Endovascular Treatment in Acute Ischemic Stroke (OPENS-2) Normobaric Hyperoxia, Sham Normobaric Hyperoxia, Endovascular Thrombectomy - Stroke, Acute, Neuroprotection | Phase 2 | Completed | Capital Medical University | 282 | 2021-04-22 | 2023-07-06 |
| Blood Pressure Management in Stroke Following Endovascular Treatment Labetalol, Hydralazine, Enalapril - Stroke, Acute, Vessels; Occlusion | Phase 2 | Completed | Hamilton Health Sciences Corporation | 30 | 2020-10-23 | 2023-11-07 |
| Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke Pioglitazone 45 mg, Placebo oral tablet - Stroke, Acute, Hyperglycemia | Phase 1 / Phase 2 | Terminated | Milton S. Hershey Medical Center | 1 | 2020-09-01 | 2022-09-15 |
| Efficacy and Safety of Trans Sodium Crocetinate (TSC) for Treatment of Suspected Stroke Trans-Sodium Crocetinate, Placebo - Stroke, Acute | Phase 2 | Terminated | Diffusion Pharmaceuticals Inc | 6 | 2019-08-22 | 2021-06-18 |
| Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage Desmopressin Injection, Normal saline - Stroke, Acute | Phase 2 | Completed | University of Nottingham | 54 | 2019-04-01 | 2022-11-15 |
| Intraarterial Alteplase Versus Placebo After Mechanical Thrombectomy Intraarterial alteplase, Placebo - Stroke, Acute | Phase 2 / Phase 3 | Completed | Hospital Clinic of Barcelona | 121 | 2018-12-05 | 2022-05-20 |
| Short-duration Selective Brain Cooling for Patients Undergoing Mechanical Thrombectomy selective brain cooling by cold saline perfusion, mechanical thrombectomy - Hypothermia, Stroke, Acute | Phase 2 / Phase 3 | Suspended | Capital Medical University | 120 | 2018-02-06 | 2020-08-04 |
| Treatment Evaluation of Acute Stroke for Using in Regenerative Cell Elements HLCM051, Placebo - Stroke, Acute | Phase 2 / Phase 3 | Completed | Healios K.K. | 206 | 2017-11-15 | 2024-01-17 |
| Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke Umbilical Cord Blood, Placebo - Stroke, Stroke, Acute | Phase 2 | Completed | Joanne Kurtzberg, MD | 79 | 2017-03-14 | 2022-12-06 |
| THR-18's Pharmacokinetics and Pharmacodynamics in Subjects With Acute Ischemic Stroke Treated With tPA THR-18, Placebo - Stroke, Acute | Phase 2 | Completed | D-Pharm Ltd. | 30 | 2013-10-01 | 2015-02-04 |
| Efficacy and Safety of FTY720 for Acute Stroke Fingolimod - Stroke, Vascular Accident | Phase 2 | Completed | Tianjin Medical University General Hospital | 22 | 2012-10-01 | 2018-10-17 |
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Stroke (31) · Ischemic Stroke (10) · Infarction, Middle Cerebral Artery (4) · Brain Diseases (2) · Cerebral Hemorrhage (2) · Hemorrhagic Stroke (2) · Hypothermia (2) · Intracranial Hemorrhages (2) · Ischemia (2) · cyclopia sequence (2) · Bites and Stings (1) · Body Temperature Changes (1) · Brain Infarction (1) · Brain Injuries (1) · Brain Ischemia (1)
Cardiovascular Diseases (30) · Central Nervous System Diseases (30) · Cerebrovascular Disorders (30) · Nervous System Diseases (30) · Vascular Diseases (30) · Brain Diseases (29) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (9) · Infarction (5) · Necrosis (5) · Brain Infarction (4) · Brain Ischemia (4) · Cerebral Arterial Diseases (4) · Cerebral Infarction (4) · Intracranial Arterial Diseases (4)
Saline Solution (3) · Labetalol (2) · Minocycline (2) · Control Groups (1) · Cool-Down Exercise (1) · Dapsone (1) · Deamino Arginine Vasopressin (1) · Enalapril (1) · Fingolimod Hydrochloride (1) · Hydralazine (1) · Ischemic Postconditioning (1) · Ischemic Preconditioning (1) · Lactic Acid (1) · National Institute of Neurological Disorders and Stroke (U.S.) (1) · Nitroglycerin (1)
Capital Medical University (2) · Aga Khan University (1) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Celularity Incorporated (1) · Centre Hospitalier Universitaire Vaudois (1) · Chinese University of Hong Kong (1) · Cidat, S.A. de C.V. (1) · D-Pharm Ltd. (1) · David Hess, MD (1) · Diffusion Pharmaceuticals Inc (1) · Hamilton Health Sciences Corporation (1) · Healios K.K. (1) · Hospices Civils de Lyon (1) · Hospital Clinic of Barcelona (1)
United States (8) · China (7) · Canada (3) · Austria (2) · France (2) · Germany (2) · Spain (2) · Switzerland (2) · United Kingdom (2) · Belgium (1) · Hong Kong (1) · Japan (1) · Mexico (1) · Pakistan (1) · Ukraine (1)
Andrew Southerland, MD (1) · Angel Chamorro, MD, PhD (1) · Anna Ramos, MD (1) · Aravind Ganesh, MD, DPhil (1) · Aristeidis H Katsanos, MD (1) · Bonaventure Yiu Ming IP, MB ChB (1) · David C Hess, MD (1) · Elisa Cuadrado, MD, PhD (1) · Fu-Dong Shi, MD,PhD (1) · James C. Grotta, MD (1) · Jayme S Knutson, PhD (1) · Jeffrey L Saver, MD (1) · Jeffrey Saver, MD (1)
PMID 22163120, PMID 17509235, PMID 19834012, PMID 20705929, PMID 21852153, PMID 22764211, PMID 25003359, PMID 25107583, PMID 26202811, PMID 27834742, PMID 29134924, PMID 33172941, PMID 33464335, PMID 35143603, PMID 35369714, PMID 35720286, PMID 37870112, PMID 38227308, PMID 39435713, PMID 39922675, PMID 40396577, PMID 40866207, PMID 41392086, PMID 42460477, PMID 42623571
2019 (1), P50NS044148 (1), P50NS044227 (1)