5 completed, 1 recruiting, 1 withdrawn. 3 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 1, Recruiting 1, Withdrawn 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 1 | Completed 1 |
Follow NoNO Inc.: new trials by email
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis With or Without Endovascular Thrombectomy NoNO-42 - Acute Ischemic Stroke | Phase 2 | Recruiting | NoNO Inc. | 600 | 2024-10-02 | 2025-07-15 |
| A Phase 1 Study to Evaluate Safety and Tolerability of NoNO-42 in Healthy Adults NoNO-42, Placebo - First-In-Human Study to Evaluate Safety of a New Drug Intended for Treatment of Acute Ischemic Stroke | Phase 1 | Completed | NoNO Inc. | 83 | 2022-11-22 | 2024-05-16 |
| Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis Placebo, Nerinetide - Stroke, Acute | Phase 3 | Completed | NoNO Inc. | 850 | 2020-12-06 | 2025-06-22 |
| Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke Nerinetide (NA-1), 2.6 mg/kg, Placebo - Stroke, Acute | Phase 3 | Completed | NoNO Inc. | 1105 | 2017-03-01 | 2022-10-10 |
| Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms NA-1, Placebo - Subarachnoid Hemorrhage, Ruptured Intracranial Aneurysm | Phase 2 | Withdrawn | NoNO Inc. | 2015-11-01 | 2015-08-04 | |
| Field Randomization of Nerinetide (NA-1) Therapy in Early Responders Nerinetide (NA-1), Placebo - Acute Cerebral Ischemia | Phase 3 | Completed | NoNO Inc. | 532 | 2015-03-26 | 2023-05-12 |
| Evaluating Neuroprotection in Aneurysm Coiling Therapy NA-1, Placebo - Stroke | Phase 2 | Completed | NoNO Inc. | 185 | 2008-08-01 | 2013-10-17 |
Stroke (5) · Ischemic Stroke (2) · Hemorrhagic Stroke (1) · Intracranial Aneurysm (1) · Ischemia (1) · Ischemic Attack, Transient (1) · Subarachnoid Hemorrhage (1)
Canada (7) · United States (4) · Australia (2) · Germany (2) · Ireland (1) · Italy (1) · Netherlands (1) · Norway (1) · Singapore (1) · South Korea (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Bijoy Menon, MBBS, MD (1) · Cameron G McDougall, MD (1) · Jim Christenson, M.D. (1) · Michael D Hill, MD (1) · Michael D Hill, MD MSc (1) · Michael D. Hill, MD MSc (1) · Michael Hill, M.D. (1) · Michael Tymianski, MD, PhD (1) · Richard Swartz, M.D. (1)
PMID 23051991, PMID 32087818, PMID 35169007, PMID 37082967, PMID 37165867, PMID 37548010, PMID 38165335, PMID 38272571, PMID 39648909, PMID 39955119, PMID 39955120, PMID 40122606