43 completed, 8 unknown, 6 terminated, 5 recruiting. 70 Phase 3, 31 Phase 2.
Follow Spinal Cord Injuries: new trials by email Literature Review of Spinal Cord Injuries trials Research Report on Spinal Cord Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) Galantamine Hydrobromide Extended Release - Spinal Cord Injury, Traumatic Spinal Cord Injury | Phase 2 / Phase 3 | Recruiting | Northwell Health | 60 | 2026-06-15 | 2026-06-04 |
| Transcutaneous Spinal Cord Stimulation for Upper Extremity Function Transcutaneous spinal cord stimulation, Upper extremity rehabilitation - Spinal Cord Injuries, Stroke | Phase 2 / Phase 3 | Recruiting | University of Alberta | 30 | 2024-06-15 | 2026-04-13 |
| Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) Probenecid 500 Milligrams (mg), probenecid 250 Milligrams (mg), Placebo - Infertility, Male | Phase 3 | Recruiting | University of Miami | 90 | 2024-01-18 | 2026-03-02 |
| Cannabinoids and an Anti-inflammatory Diet for the Treatment of Neuropathic Pain After Spinal Cord Injury Placebo diet, Anti-inflammatory diet, Nabilone Capsules - Spinal Cord Injuries, Neuropathic Pain | Phase 3 | Completed | Eldon Loh, MD | 14 | 2023-03-01 | 2025-07-22 |
| Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial brivaracetam, Placebo - Spinal Cord Injuries, Neuropathic Pain | Phase 3 | Completed | University of Minnesota | 44 | 2023-01-01 | 2026-03-18 |
| Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC Vibegron - Neurogenic Detrusor Overactivity | Phase 2 / Phase 3 | Recruiting | Urovant Sciences GmbH | 71 | 2022-10-12 | 2026-06-15 |
| Stem Cells in Spinal Cord Injury Neuro-Cells - Spinal Cord Injuries, Acute Spinal Cord Injury | Phase 2 / Phase 3 | Unknown | Neuroplast | 16 | 2022-01-18 | 2023-09-29 |
| Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury. NMES, Vitamin D, Passive movement - Spinal Cord Injury | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 6 | 2021-10-01 | 2026-01-23 |
| Vitamin D Supplementation in Individuals With a Chronic Spinal Cord Injury Cholecalciferol (Vitamin D3), Placebo - Spinal Cord Injuries, Vitamin D Deficiency | Phase 3 | Completed | Swiss Paraplegic Research, Nottwil | 50 | 2021-05-19 | 2024-03-08 |
| Epidural Stimulation and Resistance Training After SCI Exoskeletal assisted walking, Epidural Stimulation, Resistance Training - Spinal Cord Injuries | Phase 2 / Phase 3 | Recruiting | United States Department of Defense | 20 | 2021-02-03 | 2026-01-02 |
| Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction Human Milk Oligosaccharides (HMO), Placebo - Spinal Cord Injuries, Neurogenic Bowel | Phase 3 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 30 | 2021-01-27 | 2023-12-13 |
| Neostigmine and Glycopyrrolate by Iontophoresis Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics - Spinal Cord Injuries, Constipation | Phase 3 | Active not recruiting | James J. Peters Veterans Affairs Medical Center | 6 | 2020-11-06 | 2024-04-08 |
| Effects of 5HTP on the Injured Human Spinal Cord 5-Hydroxytryptophan 100 MG, 5-Hydroxytryptophan, Carbidopa - Spinal Cord Injuries | Phase 2 / Phase 3 | Active not recruiting | University of Alberta | 6 | 2020-07-01 | 2026-09-16 |
| High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients. 4-Aminopyridine, Placebo oral capsule - Spinal Cord Injuries, Chronic | Phase 3 | Unknown | Coordinación de Investigación en Salud, Mexico | 150 | 2019-07-17 | 2021-02-21 |
| Effects of 5HTP and LDOPA on CNS Excitability After SCI 5HTP, L-DOPA, Placebo oral tablet - Spinal Cord Injuries | Phase 2 / Phase 3 | Suspended | Jessica M D'Amico | 30 | 2019-06-19 | 2022-10-17 |
| Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury Gentamicin Sulfate - Urinary Tract Infections, Spinal Cord Injuries | Phase 2 / Phase 3 | Completed | University of Michigan | 23 | 2018-08-24 | 2024-06-25 |
| A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Safety and Efficacy of ES135 in Subjects With Spinal Cord Injury ES135 - Spinal Cord Injuries | Phase 3 | Suspended | Eusol Biotech Co., Ltd. | 160 | 2018-03-07 | 2024-05-08 |
| The Effect of Gabapentin Used as a Preemptive to the Emergence and Development Chronic Neuropathic Pain in Patients After Spinal Cord Trauma Gabapentin, Metamizol, Tramadol - Chronic Pain Due to Trauma, Spinal Cord Injuries | Phase 3 | Withdrawn | Masaryk University | 2017-10-01 | 2019-03-07 | |
| Treatment of Post-SCI Hypotension Midodrine Hydrochloride - Spinal Cord Injury, Autonomic Dysreflexia | Phase 2 / Phase 3 | Completed | James J. Peters Veterans Affairs Medical Center | 66 | 2017-06-01 | 2025-02-21 |
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Quadriplegia (10) · Paraplegia (7) · Neuralgia (6) · Pain (4) · Spinal Cord Compression (4) · Spinal Cord Diseases (4) · Wounds and Injuries (4) · Hypotension, Orthostatic (3) · Muscle Spasticity (3) · Stroke (3) · Bone Diseases (2) · Central Nervous System Diseases (2) · Erectile Dysfunction (2) · Hypogonadism (2)
Nervous System Diseases (69) · Central Nervous System Diseases (68) · Spinal Cord Diseases (66) · Trauma, Nervous System (66) · Wounds and Injuries (66) · Pathological Conditions, Signs and Symptoms (32) · Signs and Symptoms (30) · Neurologic Manifestations (25) · Paralysis (10) · Cardiovascular Diseases (8) · Vascular Diseases (8) · Immune System Diseases (7) · Neuromuscular Diseases (7) · Peripheral Nervous System Diseases (7) · Male Urogenital Diseases (6)
4-Aminopyridine (3) · Pregabalin (3) · Zoledronic Acid (3) · Carbidopa (2) · Cholecalciferol (2) · Denosumab (2) · Methylprednisolone (2) · Midodrine (2) · NG-Nitroarginine Methyl Ester (2) · Resistance Training (2) · Risedronic Acid (2) · 5-Hydroxytryptophan (1) · Botulinum Toxins, Type A (1) · Cell- and Tissue-Based Therapy (1) · Curcumin (1)
VA Office of Research and Development (6) · James J. Peters Veterans Affairs Medical Center (3) · US Department of Veterans Affairs (3) · University of Alberta (3) · Acorda Therapeutics (2) · Amgen (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · Thomas Jefferson University (2) · Toronto Rehabilitation Institute (2) · University of Melbourne (2) · University of Miami (2) · AOSpine North America Research Network (1) · Assistance Publique - Hôpitaux de Paris (1) · Barth Wilsey (1)
United States (39) · Canada (17) · Australia (5) · Japan (4) · Czechia (3) · New Zealand (3) · Spain (3) · China (2) · Denmark (2) · Hong Kong (2) · Ireland (2) · Italy (2) · Lithuania (2) · Malaysia (2) · Philippines (2)
Jessica D'Amico, PhD (3) · B. Cathy Craven, MD, FRCPC (2) · William Bauman, MD (2) · Andrea L Behrman, PhD (1) · Andrea Townson, Dr. (1) · Andrew Blight (1) · Andrew Blight, MD (1) · Anke Scheel-Sailer, Dr. med. (1) · Anne Pelletier-Cameron, MD (1) · Antonio Oliviero, MD (1) · Antonio Oliviero, MD, PhD (1) · Arthur Prochazka (1) · Ashraf Gorgey, PhD PT (1)
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R01DA030424 (1), R01HD056267 (1)