93 completed, 55 recruiting, 27 unknown, 17 terminated. 158 Not applicable, 22 Phase 2, 16 Phase 1, 12 Phase 3, 8 Phase 4.
Follow Quadriplegia: new trials by email Literature Review of Quadriplegia trials Research Report on Quadriplegia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation - Spinal Cord Injuries (SCI) | Not applicable | Not yet recruiting | National University Hospital, Singapore | 24 | 2027-03-30 | 2026-05-14 |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| Evaluation of a Voice-Activated Call Light System for Clients With Limited Upper-Extremity Mobility voice-activated call light - Spinal Cord Injury (=3 Years), Traumatic Brain Injury (TBI) Patients | Enrolling by invitation | Quality Living, Inc. | 80 | 2026-10-15 | 2026-10-14 | |
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy - Spinal Cord Injuries (SCI), Chronic Pain | Not applicable | Not yet recruiting | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 40 | 2026-10-01 | 2026-09-29 |
| A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury NVG-291, Placebo - Chronic Spinal Cord Injury | Phase 3 | Recruiting | NervGen Pharma | 150 | 2026-09-28 | 2026-10-22 |
| Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation Protocol 1: Combination of activity-based therapy and sham spinal cord stimulation, Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation - Spinal Cord Injury Cervical, Spinal Cord Injury, Acute | Not applicable | Not yet recruiting | Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal | 40 | 2026-09-01 | 2026-07-28 |
| Psilocybin to Treat Depression in Spinal Cord Injury Psilocybin (Usona Institute) - Spinal Cord Injury, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | James J. Peters Veterans Affairs Medical Center | 30 | 2026-08-06 | 2026-08-10 |
| Abdominal Stimulation to Improve Cough After Spinal Cord Injury Respiratory Muscle Stimulator, Supervised Cough Training - Spinal Cord Injuries (SCI), Respiratory Insufficiency | Not applicable | Not yet recruiting | Liberate Medical | 150 | 2026-08-01 | 2026-06-04 |
| Innovative Brain-Computer Interface for People With Spinal Cord Injury ECoG (electrocorticography) sensing - Spinal Cord Injury, Tetraplegia C1-C4 | Not applicable | Recruiting | UMC Utrecht | 1 | 2026-08-01 | 2026-06-11 |
| Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia IWBCIS - Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis | Not applicable | Recruiting | BCIFlex Medical Technology Co., Ltd. | 34 | 2026-07-15 | 2026-08-25 |
| Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) Galantamine Hydrobromide Extended Release - Spinal Cord Injury, Traumatic Spinal Cord Injury | Phase 2 / Phase 3 | Recruiting | Northwell Health | 60 | 2026-06-15 | 2026-06-04 |
| Virtual Reality Assessment of Control Interfaces for the Use a Neuroprosthesis in Individuals With Tetraplegia Virtual reality used as a simulation tool to evaluate and optimize the use of control interfaces - Intervention Study | Not applicable | Completed | Centre Bouffard Vercelli - USSAP | 10 | 2026-04-10 | 2026-06-11 |
| Home-Based Digital Rehabilitation Program Optimized With Transcutaneous Spinal Cord Stimulation for Upper Limb Functional Enhancement in Tetraplegia (HOPE): A Safety, Efficacy, and Feasibility Study Home-based digital rehabilitation programme with tSCS - Spinal Cord Injury, Quadriplegia/Tetraplegia | Not applicable | Not yet recruiting | Singapore General Hospital | 9 | 2026-04-01 | 2026-02-27 |
| Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) Connexus Brain-Computer Interface - Amyotrophic Lateral Sclerosis, Neuromuscular Disease | Not applicable | Recruiting | Paradromics | 2 | 2026-03-31 | 2026-04-14 |
| Chinese-Specific Speech Imagery Coding Using High-Density ECoG Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation - Aphasia, Dysarthria | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-03-15 | 2026-03-10 |
| SCI Epidemiology and Complications Retrospective data analysis - Spinal Cord Injury | Not yet recruiting | Bandırma Onyedi Eylül University | 50 | 2026-03-01 | 2026-02-20 | |
| Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE) Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE) | Enrolling by invitation | Healing Hope International | 25 | 2026-03-01 | 2026-03-23 | |
| MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System Mind Extender (MindEx) - Paralysis; Quadriplegic, Quadraplegia | Not applicable | Recruiting | Nader Pouratian | 2 | 2026-02-20 | 2026-10-01 |
Showing 20 of 229. Sign in to see all of them.
Spinal Cord Injuries (154) · Paraplegia (58) · Paralysis (33) · Amyotrophic Lateral Sclerosis (25) · Locked-In Syndrome (19) · Brain Stem Infarctions (17) · Cerebral Palsy (15) · Stroke (12) · Muscular Dystrophies (11) · Muscle Spasticity (9) · Paresis (7) · Hemiplegia (6) · Motor Activity (6) · Neurologic Manifestations (6)
Pathological Conditions, Signs and Symptoms (229) · Signs and Symptoms (229) · Nervous System Diseases (225) · Neurologic Manifestations (223) · Paralysis (196) · Central Nervous System Diseases (180) · Spinal Cord Diseases (158) · Trauma, Nervous System (157) · Wounds and Injuries (154) · Brain Diseases (42) · Neuromuscular Diseases (38) · Metabolic Diseases (33) · Nutritional and Metabolic Diseases (33) · Cardiovascular Diseases (29) · Vascular Diseases (28)
Brain-Computer Interfaces (8) · Transcranial Direct Current Stimulation (6) · Electrocorticography (3) · Buspirone (2) · Drug Delivery Systems (2) · Exercise (2) · Extracorporeal Shockwave Therapy (2) · Midodrine (2) · NG-Nitroarginine Methyl Ester (2) · Neural Prostheses (2) · Occupational Therapy (2) · Tablets (2) · Transcranial Magnetic Stimulation (2) · exoenzyme C3, Clostridium botulinum (2) · 4-Aminopyridine (1)
VA Office of Research and Development (10) · James J. Peters Veterans Affairs Medical Center (7) · Neuralink Corp (6) · Wandercraft (6) · Assistance Publique - Hôpitaux de Paris (5) · Washington University School of Medicine (5) · Columbia University (4) · Johns Hopkins University (4) · Leigh R. Hochberg, MD, PhD. (4) · Oregon Health and Science University (4) · Shepherd Center, Atlanta GA (4) · US Department of Veterans Affairs (4) · University of British Columbia (4) · University of Miami (4) · Case Western Reserve University (3)
United States (127) · France (23) · Canada (19) · United Kingdom (11) · China (7) · Switzerland (6) · Italy (5) · Netherlands (5) · Israel (4) · Mexico (4) · Turkey (Türkiye) (4) · Norway (3) · Singapore (3) · Brazil (2) · Egypt (2)
Miroslav Radulovic, MD (4) · Maria Knikou, PT, PhD (3) · Nick F Ramsey, PhD (3) · Richard A Andersen, PhD (3) · Charles Liu, MD, PhD (2) · Henrik Gollee, PhD (2) · Jennifer L Collinger, PhD (2) · John P Handrakis, PT, DPT, EdD (2) · Kim Anderson, PhD (2) · Mark S Nash, PhD (2) · Michael L Boninger, MD (2) · Nathan Crone, MD (2) · Nathan E Crone, MD (2) · Noam Y Harel, MD, PhD (2)
PMID 28899825, PMID 39134021, PMID 18406958, PMID 26987662, PMID 29209023, PMID 29553484, PMID 32494819, PMID 34847547, PMID 41535942, PMID 42622482, PMID 11588741, PMID 15224087, PMID 15672628, PMID 17385265, PMID 17873417, PMID 17947042, PMID 17965289, PMID 18602082, PMID 18645190, PMID 19651280, PMID 20012982, PMID 21235821, PMID 21372246, PMID 21381984, PMID 21436513, PMID 21652288, PMID 21762873, PMID 22330108, PMID 22525310, PMID 22531737, PMID 22596161, PMID 22692932, PMID 23253623, PMID 23500182, PMID 23542776, PMID 23700789, PMID 23838067, PMID 23844986, PMID 24090266, PMID 24284925, PMID 24534779, PMID 25385765, PMID 25514320, PMID 25520035, PMID 25531297, PMID 25767422, PMID 26047468, PMID 26397252, PMID 26413781, PMID 26857270
U01DC017844 (2), 1DP2DC021055 (1), 1RC1EB010915-01 (1), 1UG3NS120191-01 (1), 2017 (1), 2019 (1), I01RX000528 (1), I01RX003803 (1), K99HD117041 (1), P2CHD086844 (1), R01DC009899 (1), R01DC014034 (1), R01HD091278 (1), R01HD117313 (1), R01NS061304 (1)