8 completed, 3 recruiting, 2 active not recruiting. 4 Phase 2, 3 Not applicable, 3 Phase 1, 2 Early Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Recruiting 1 |
| Not applicable | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Early Phase 1 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 3 | 2 | Completed 2 |
Follow NG-Nitroarginine Methyl Ester: new trials by email Literature Review of NG-Nitroarginine Methyl Ester trials Research Report on NG-Nitroarginine Methyl Ester
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heat, Microvascular Function and Aging Passive Heating, L-NAME - Aging | Early Phase 1 | Active not recruiting | William Hughes | 20 | 2025-05-01 | 2026-07-09 |
| Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults NG-nitro-L-arginine methyl ester (L-NAME) - Major Depressive Disorder | Not applicable | Recruiting | University of Delaware | 18 | 2025-01-06 | 2025-09-17 |
| Effects of an Antioxidant Supplement on Blood Vessel Health MitoQ, Placebo, MitoTempo - Healthy | Phase 2 | Recruiting | University of Georgia | 60 | 2024-07-01 | 2024-12-09 |
| Sex Differences in the Vascular Effects of E-cigarette Use Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure - E-cigarette Use | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 80 | 2023-12-02 | 2025-12-15 |
| Estrogen and Microvascular Function Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside - Estrogen, Cardiovascular Diseases | Active not recruiting | Medical College of Wisconsin | 45 | 2023-10-12 | 2026-07-29 | |
| Local Antioxidant Therapy Vasoconstriction Effects in Different Races Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 22 | 2018-10-15 | 2024-06-11 |
| The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction BQ-788, BQ-123, L-Arginine - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 19 | 2018-10-01 | 2024-06-11 |
| The Effect of Antioxidants on Skin Blood Flow-BH4 Control: Lacated Ringers, Apocynin, Allopurinol - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 16 | 2018-01-08 | 2018-09-26 |
| Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia Microdialysis of fluconazole, vehicle and N(G)-nitro-L-arginine-methyl ester (L-NMMA) - Healthy Volunteers | Not applicable | Completed | University Hospital, Grenoble | 20 | 2011-02-01 | 2012-09-05 |
| Safety and Efficacy of L-NAME and Midodrine to Increase MAP L-NAME, Midodrine, Placebo - Orthostatic Hypotension, Spinal Cord Injury | Phase 2 | Completed | US Department of Veterans Affairs | 34 | 2010-05-01 | 2014-04-23 |
| Exhaled Levels of Nitric Oxide N-Nitro L-arginine-methylester (L-NAME) - Tetraplegia, Asthma | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 23 | 2006-12-01 | 2020-02-28 |
| Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling L-NAME, L-Arginine, Phenylephrine - Cardiovascular Diseases | Not applicable | Completed | Washington University School of Medicine | 54 | 2005-09-01 | 2018-09-12 |
| Prevention of Low Blood Pressure in Persons With Tetraplegia N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver - Hypotension, Spinal Cord Injury | Phase 2 / Phase 3 | Completed | US Department of Veterans Affairs | 16 | 2003-06-01 | 2014-05-19 |
Cardiovascular Diseases (6) · Spinal Cord Injuries (3) · Hypotension, Orthostatic (2) · Quadriplegia (2) · Asthma (1) · Depressive Disorder, Major (1) · Hypertension (1) · Hypotension (1) · Vaping (1)
The University of Texas at Arlington (3) · US Department of Veterans Affairs (2) · Anna Stanhewicz, PhD (1) · Medical College of Wisconsin (1) · University Hospital, Grenoble (1) · University of Delaware (1) · University of Georgia (1) · VA Office of Research and Development (1) · Washington University School of Medicine (1) · William Hughes (1)
United States (12) · France (1)
Jean-Luc Cracowski, MD,PhD (1) · Jill Wecht, EdD (1) · Miroslav Radulovic, MD (1) · Robert Gropler, MD (1) · William Bauman, MD (1)
PMID 21762873, PMID 17385265, PMID 17965289, PMID 19651280, PMID 20012982, PMID 23700789
P20GM113125 (1), R01AG015466 (1)