13 terminated. 13 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Terminated 13 |
| Phase 1 | 3 | Terminated 3 |
| Phase 3 | 3 | Terminated 3 |
Follow Smoking Cessation: new trials by email Literature Review of Smoking Cessation trials Research Report on Smoking Cessation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava Kava, Placebo - Smoking | Phase 2 | Terminated | University of Florida | 19 | 2022-06-09 | 2026-09-03 |
| High Dose Bupropion for Smoking Cessation - Pilot Study Bupropion Hydrochloride - Smoking Cessation, Smoking, Tobacco | Phase 2 | Terminated | University of Southern California | 12 | 2021-09-01 | 2023-07-17 |
| Study of EMB-001 as a Potential Smoking Cessation Treatment EMB-001 - Tobacco Use Disorder | Phase 1 / Phase 2 | Terminated | Embera NeuroTherapeutics, Inc. | 13 | 2021-06-10 | 2026-11-05 |
| Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO) Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders - Smoking Cessation | Phase 2 | Terminated | University of Oklahoma | 34 | 2020-01-07 | 2024-02-06 |
| Mechanisms of Lorcaserin for Smoking Cessation Lorcaserin Oral Tablet, Placebo oral tablet - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Terminated | The Mind Research Network | 3 | 2019-12-04 | 2023-03-20 |
| Mindfulness Training Plus Oxytocin Effects on Smoking Behavior Oxytocin, Mindfulness, Saline Solution - Smoking, Smoking Cessation | Phase 2 / Phase 3 | Terminated | University of Southern California | 20 | 2018-10-10 | 2024-06-14 |
| Neuro Biomarkers of Smoking Behavior Novolin R - Smoking Cessation | Phase 2 | Terminated | University of Illinois at Chicago | 4 | 2018-09-12 | 2021-03-02 |
| A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers Cytisine - Smoking Cessation | Phase 1 / Phase 2 | Terminated | Achieve Life Sciences | 26 | 2017-10-06 | 2019-10-21 |
| Addressing Post Cessation Weight Gain lorcaserin, Varenicline, Placebo - Obesity, Smoking Cessation | Phase 2 / Phase 3 | Terminated | Mayo Clinic | 84 | 2016-06-15 | 2021-06-10 |
| Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement Nicotine patch, Nicotine mouthspray - Tobacco Use Disorder, Nicotine Dependence | Phase 2 / Phase 3 | Terminated | Centre for Addiction and Mental Health | 18 | 2015-07-01 | 2018-07-19 |
| Cholecalciferol Supplementation in Strengthening Inspiratory Muscles in Cholecalciferol-Deficient Patients With Chronic Obstructive Pulmonary Disease Cholecalciferol, Laboratory Biomarker Analysis, Multivitamin - Chronic Obstructive Pulmonary Disease, Muscle Weakness | Phase 2 | Terminated | Roswell Park Cancer Institute | 4 | 2014-04-16 | 2017-02-15 |
| D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS) Cognitive Behavioral Therapy, Nicotine Replacement Therapy - Nicotine Dependence, Smoking Cessation | Phase 1 / Phase 2 | Terminated | Mclean Hospital | 22 | 2013-04-01 | 2018-08-31 |
| A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence EVP-6124, Placebo Capsule, NicoDerm Patch (Active) - Nicotine Dependence, Smoking Cessation | Phase 2 | Terminated | A. Eden Evins | 345 | 2011-12-01 | 2017-04-06 |
Tobacco Use Disorder (6) · Smoking (4) · Behavior, Addictive (1) · Cigarette Smoking (1) · Insulin Resistance (1) · Muscle Weakness (1) · Obesity (1) · Pulmonary Disease, Chronic Obstructive (1) · Tobacco Smoking (1) · Tobacco Use (1) · Tobacco Use Cessation (1)
Behavior (13) · Health Behavior (13) · Chemically-Induced Disorders (6) · Mental Disorders (6) · Substance-Related Disorders (6) · Nutritional and Metabolic Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Body Weight (1) · Chronic Disease (1) · Compulsive Behavior (1) · Disease Attributes (1) · Glucose Metabolism Disorders (1) · Hyperinsulinism (1) · Impulsive Behavior (1)
Nicotine Replacement Therapy (2) · Tobacco Use Cessation Devices (2) · Varenicline (2) · lorcaserin (2) · 7-chloro-N-quinuclidin-3-yl-benzo(b)thiophene-2-carboxamide (1) · Behavior Therapy (1) · Bupropion (1) · Cholecalciferol (1) · Cognitive Behavioral Therapy (1) · Exercise (1) · Geritol (1) · Insulin (1) · Mindfulness (1) · Nicotine (1) · Nicotine Chewing Gum (1)
University of Southern California (2) · A. Eden Evins (1) · Achieve Life Sciences (1) · Centre for Addiction and Mental Health (1) · Embera NeuroTherapeutics, Inc. (1) · Mayo Clinic (1) · Mclean Hospital (1) · Roswell Park Cancer Institute (1) · The Mind Research Network (1) · University of Florida (1) · University of Illinois at Chicago (1) · University of Oklahoma (1)
United States (11) · Canada (1) · United Kingdom (1)
Adam M Leventhal, PhD (1) · Ajna Hamidovic, PharmD, MS (1) · Anne Eden Evins, MD, MPH (1) · Annelize Koch, MD (1) · Bruce McCarthy, MD (1) · Christian Hendershot, Ph.D. (1) · Darla Kendzor, PhD (1) · Eric Claus, Ph.D. (1) · Kevin P. Hill, MD, MHS (1) · Laurie Zawertailo, PhD (1) · Martin Mahoney (1) · Matthew Kirkpatrick, PhD (1) · Maurizio Fava, MD (1) · Peter Selby, MBBS (1) · Ramzi Salloum, PhD (1)
PMID 34611902, PMID 36160639, PMID 36653872, PMID 37889541, PMID 42142878
K23DA037299 (1), P30CA016056 (1), P50CA090440 (1), R01DA030992 (1)