8 not yet recruiting. 8 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Not yet recruiting 8 |
| Phase 1 | 2 | Not yet recruiting 2 |
| Phase 3 | 1 | Not yet recruiting 1 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With Tebentafusp Dexamethasone - Uveal Melanoma, Metastatic | Phase 2 | Not yet recruiting | University of California, San Diego | 34 | 2026-11-01 | 2026-09-03 |
| CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock Methylprednisone, Standard of Care (SOC) - Cardiogenic Shock, Heart Failure | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 30 | 2026-10-01 | 2026-08-13 |
| NAI for Sepsis With Persistent Lymphopenia Nogapendekin alfa inbakicept (NAI), Standard of Care (SOC) - Sepsis, Septic Shock | Phase 2 | Not yet recruiting | ImmunityBio, Inc. | 50 | 2026-07-06 | 2026-05-11 |
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial Point-of-care large language model decision support (ChatGPT-5) - Critical Illness, Sepsis | Phase 1 / Phase 2 | Not yet recruiting | MetroWest Artificial Intelligence Research Workgroup | 1000 | 2026-01-01 | 2025-12-18 |
| Sevoflurane Sedation in Patients With Septic Shock Sevoflurane, Control Group - Shock, Septic | Phase 2 | Not yet recruiting | University of Zurich | 153 | 2026-01-01 | 2025-04-01 |
| Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock Methylene Blue, Placebo - Neonatal Sepsis, Shock, Septic | Phase 2 / Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 130 | 2024-03-15 | 2024-03-12 |
Shock, Septic (5) · Sepsis (3) · Critical Illness (2) · Acute Kidney Injury (1) · Confusion (1) · Cytokine Release Syndrome (1) · Heart Failure (1) · Hemostatic Disorders (1) · Inflammation (1) · Lymphopenia (1) · Multiple Organ Failure (1) · Neonatal Sepsis (1) · Neoplasm Metastasis (1) · Shock, Cardiogenic (1)
Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Inflammation (7) · Systemic Inflammatory Response Syndrome (7) · Infections (6) · Sepsis (3) · Cardiovascular Diseases (2) · Disease Attributes (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Vascular Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Cytopenia (1) · Eye Diseases (1)
Standard of Care (2) · ALT-803 (1) · Calcium Dobesilate (1) · Control Groups (1) · Dexamethasone (1) · Methylene Blue (1) · Propofol (1) · Saline Solution (1) · Sevoflurane (1) · esmolol (1)
Brigham and Women's Hospital (1) · ImmunityBio, Inc. (1) · John Basmaji (1) · MetroWest Artificial Intelligence Research Workgroup (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · University Hospital, Strasbourg, France (1) · University of California, San Diego (1) · University of Zurich (1)
United States (3) · France (1) · India (1) · Switzerland (1)
Eric Silverman, M.D. (1) · John Basmaji (1) · Martin Schlaepfer, PD (1) · Soo Park, MD (1) · Sourabh Dutta, MD, PhD (1)
PMID 11588440, PMID 12500513, PMID 12519925, PMID 14759425, PMID 16134766, PMID 17698886, PMID 18477932, PMID 21246318, PMID 26683506, PMID 27673307, PMID 28723883, PMID 29151412, PMID 29508706, PMID 29936590, PMID 30231909, PMID 32270211, PMID 32453920, PMID 32520577, PMID 34719443, PMID 36237547, PMID 36705345, PMID 36915146, PMID 40009025, PMID 8648456, PMID 9250657