11 completed, 3 terminated, 2 unknown, 1 not yet recruiting. 5 Not applicable, 4 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Shock, Traumatic: new trials by email Literature Review of Shock, Traumatic trials Research Report on Shock, Traumatic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients Multiple Trauma, Polytrauma | Not yet recruiting | Assiut University | 300 | 2026-10-01 | 2026-09-30 | |
| REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam ResQFoam - Hemorrhagic Shock, Trauma | Not applicable | Recruiting | Arsenal Medical, Inc. | 40 | 2025-08-07 | 2025-11-10 |
| Efficacy and Safety of Early Use PCC in Severe Trauma 4 factor Prothrombin Complex Concentrates - Severe Trauma, Traumatic Shock | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 380 | 2023-08-10 | 2026-04-20 |
| Transfusion for Major Haemorrhage in Trauma - Characteristics and Outcomes Trauma, Hemorrhage | Completed | Karolinska University Hospital | 161 | 2022-10-31 | 2026-08-10 | |
| Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model Ambispective validation of machine learning-based predictive model - Wounds and Injuries, Traumatic Shock | Completed | Assistance Publique - Hôpitaux de Paris | 1584 | 2022-07-01 | 2025-02-18 | |
| Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients Etomidate Injection 0.2 mg/kg, Ketamine injection 2 mg/kg - Trauma, Shock, Traumatic | Not applicable | Terminated | Ajou University School of Medicine | 10 | 2019-10-01 | 2022-03-03 |
| The AT-REBOA Target Trial Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) - Hemorrhage, Shock, Traumatic | Completed | Medical University of Graz | 44 | 2019-01-01 | 2025-01-22 | |
| Inflammation Indıces and Mortality in Adult Crush Syndrome Crush Syndrome, Rhabdomyolysis | Completed | Ataturk University | 325 | 2018-01-01 | 2026-08-18 | |
| Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study Observational - Trauma, Shock, Traumatic | Completed | Mackay Memorial Hospital | 105641 | 2016-01-01 | 2022-09-22 | |
| AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock Vasopressin - Traumatic Shock | Phase 2 | Completed | University of Pennsylvania | 101 | 2013-05-01 | 2019-05-21 |
| Polydatin Injectable (HW6) for Shock Treatment Polydatin Injectable - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Unknown | Neptunus Pharmaceuticals Inc. | 240 | 2013-02-01 | 2013-01-30 |
| Prehospital Norepinephrine and Early Mortality in Traumatic Shock Norepinephrine - Traumatic Shock, Hemorrhagic Shock | Completed | University of Maryland, Baltimore | 2164 | 2013-01-01 | 2022-02-10 | |
| Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Saline - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 348 | 2011-05-01 | 2013-08-22 |
| Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Ringers Lactate solution - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 51 | 2009-12-01 | 2013-08-19 |
| A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients Intraoperative Hypotensive Resuscitation - Hemorrhagic Shock, Trauma | Not applicable | Unknown | Baylor College of Medicine | 271 | 2007-07-01 | 2010-12-01 |
| Low Dose Vasopressin in Traumatic Shock normal saline control, vasopressin - Injuries, Shock, Traumatic | Early Phase 1 | Terminated | The University of Texas Health Science Center at San Antonio | 81 | 2007-02-01 | 2019-06-18 |
| Hypertonic Resuscitation Following Traumatic Injury 7.5% hypertonic saline/6% Dextran-70 (HSD), 7.5% hypertonic saline (HS), 0.9% normal saline - Shock, Traumatic | Phase 3 | Terminated | University of Washington | 895 | 2006-05-01 | 2011-03-01 |
| Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury Hypertonic Saline-Dextran Solution, Lactated Ringer's Solution - Respiratory Distress Syndrome, Adult, Head Injuries, Closed | Not applicable | Completed | University of Washington | 209 | 2003-04-01 | 2021-05-03 |
Wounds and Injuries (12) · Shock, Hemorrhagic (8) · Hemorrhage (5) · Shock (4) · Multiple Trauma (3) · Acidosis, Lactic (2) · Brain Injuries, Traumatic (1) · Critical Illness (1) · Crush Syndrome (1) · Diabetes Insipidus (1) · Emergencies (1) · Exsanguination (1) · Head Injuries, Closed (1) · Hypotension (1)
Pathologic Processes (18) · Pathological Conditions, Signs and Symptoms (18) · Shock (13) · Hemorrhage (6) · Wounds and Injuries (6) · Acid-Base Imbalance (2) · Acidosis (2) · Craniocerebral Trauma (2) · Disease Attributes (2) · Metabolic Diseases (2) · Nervous System Diseases (2) · Nutritional and Metabolic Diseases (2) · Trauma, Nervous System (2) · Brain Diseases (1) · Brain Injuries (1)
PEG-hemoglobin (2) · Ringer's Lactate (2) · Saline Solution (2) · Vasopressins (2) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (2) · Etomidate (1) · Ketamine (1) · Norepinephrine (1) · Saline Solution, Hypertonic (1) · Sodium Chloride (1) · Watchful Waiting (1) · hypertonic saline-dextran solution (1) · polynitroxylated pegylated hemoglobin (1)
Sangart (2) · University of Washington (2) · Ajou University School of Medicine (1) · Arsenal Medical, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Ataturk University (1) · Baylor College of Medicine (1) · Karolinska University Hospital (1) · Mackay Memorial Hospital (1) · Medical University of Graz (1) · Neptunus Pharmaceuticals Inc. (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · The University of Texas Health Science Center at San Antonio (1) · University of Maryland, Baltimore (1)
United States (7) · France (3) · Austria (2) · Germany (2) · South Africa (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Canada (1) · China (1) · Colombia (1) · Israel (1) · New Zealand (1) · Norway (1) · Singapore (1)
Karim Brohi, MD (2) · Carrie A Sims, MD, MS (1) · Eileen Bulger (1) · In Kyong Yi, MD (1) · Justin E Richards, MD (1) · Matthew M Carrick, MD (1) · Myron L Weisfeldt, MD (1) · Pierre Bouzat, MD, PhD (1) · Stephen M. Cohn, MD (1) · Timothy Pritts, MD (1) · Tobias Gauss, MD (1) · Tse-Hao Chen, M.D. (1) · YU Lin, PhD (1)
PMID 31461138, PMID 18283138, PMID 21161222, PMID 21178763, PMID 25072443, PMID 25782753, PMID 29793591, PMID 37222717, PMID 38441108, PMID 39745669, PMID 42681637
R01HL073233 (1), U01HL077863 (1)