61 completed. 61 Phase 2, 13 Phase 1, 10 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 61 | Completed 61 |
| Phase 1 | 13 | Completed 13 |
| Phase 3 | 10 | Completed 10 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy Adults Oxymetazoline HCl 0.05% nasal gel, Placebo nasal gel - Nasal Congestion, Nasal Obstruction | Phase 2 | Completed | Bayer | 120 | 2026-04-20 | 2026-06-08 |
| Sedation vs No Sedation in Mechanically Ventilated COPD Patients Midalozam - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Completed | Al-Azhar University | 100 | 2025-04-14 | 2026-06-02 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON] - Tetralogy of Fallot, Pulmonary Insufficiency | Phase 1 / Phase 2 | Completed | Nemours Children's Clinic | 25 | 2022-08-23 | 2026-04-27 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome AD981, Placebo - Obesity Hypoventilation Syndrome (OHS) | Phase 2 | Completed | Istituto Auxologico Italiano | 15 | 2022-06-21 | 2025-02-27 |
| Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature) - Acute Respiratory Distress Syndrome, Critical Illness | Phase 2 | Completed | Massachusetts General Hospital | 488 | 2021-10-13 | 2024-09-27 |
| Totally Transdermal Sedation in the Weaning From Remifentanil Infusion Fentanyl Transdermal System, Remifentanil - Respiratory Insufficiency, Ventilator Weaning | Phase 2 | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2021-02-15 | 2024-05-17 |
| Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Mesenchymal Stromal Cells, Supportive Care - Sars-CoV2, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 28 | 2021-02-12 | 2026-10-21 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19 L-Citrulline, Placebo - Acute Hypoxemic Respiratory Failure | Phase 2 | Completed | Asklepion Pharmaceuticals, LLC | 65 | 2020-10-15 | 2023-02-22 |
| Tenecteplase in Patients With COVID-19 Tenecteplase, Placebo - COVID-19, Respiratory Failure | Phase 2 | Completed | Hooman Poor | 13 | 2020-09-25 | 2023-04-06 |
| Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation Convalescent Plasma, Standard of Care - Covid19, Mechanical Ventilation Complication | Phase 2 | Completed | University of Liege | 475 | 2020-09-11 | 2024-10-29 |
| Telmisartan in Respiratory Failure Due to COVID-19 Telmisartan - COVID-19, Respiratory Insufficiency | Phase 2 | Completed | Abraham Edgar Gracia-Ramos | 66 | 2020-08-12 | 2023-10-05 |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure Iloprost, Isotonic saline - COVID-19, Respiratory Failure | Phase 2 | Completed | Pär Johansson | 80 | 2020-06-15 | 2024-05-07 |
| Study of Efficacy and Safety of MAS825 in Patients With COVID-19 MAS825, Placebo, Standard of Care (SoC) - COVID-19 Pneumonia, Impaired Respiratory Function | Phase 2 | Completed | Novartis Pharmaceuticals | 140 | 2020-06-11 | 2022-08-10 |
| Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury Ibrutinib, Placebo - CoronaVirus Induced Disease-2019 (COVID-19) | Phase 2 | Completed | AbbVie | 46 | 2020-06-06 | 2022-06-01 |
| Study of Efficacy and Safety of DV890 in Patients With COVID-19 Pneumonia DFV890, Standard of Care (SoC) - COVID-19 Pneumonia, Impaired Respiratory Function | Phase 2 | Completed | Novartis Pharmaceuticals | 143 | 2020-05-27 | 2022-07-26 |
| Inhaled Iloprost for Suspected COVID-19 Respiratory Failure Inhaled ILOPROST - COVID-19, ARDS, Human | Phase 2 | Completed | Hamad Medical Corporation | 40 | 2020-05-23 | 2022-03-29 |
Showing 20 of 61. Sign in to see all of them.
COVID-19 (13) · Nasal Obstruction (11) · Respiratory Distress Syndrome (7) · Critical Illness (5) · Coronavirus Infections (4) · Pulmonary Disease, Chronic Obstructive (4) · Airway Obstruction (3) · Sneezing (3) · Acute Lung Injury (2) · Anxiety Disorders (2) · Dyspnea (2) · Obesity Hypoventilation Syndrome (2) · Pneumonia (2) · Pneumonia, Viral (2)
Respiration Disorders (61) · Respiratory Tract Diseases (61) · Lung Diseases (23) · Pathological Conditions, Signs and Symptoms (23) · Infections (20) · Respiratory Tract Infections (16) · Virus Diseases (16) · RNA Virus Infections (15) · Coronaviridae Infections (14) · Nidovirales Infections (14) · Pathologic Processes (14) · Pneumonia (12) · Pneumonia, Viral (12) · Airway Obstruction (11)
Standard of Care (4) · Dexmedetomidine (3) · Sodium Chloride (3) · Culture Media (2) · Glucose (2) · Remifentanil (2) · Saline Solution (2) · AZD-3199 (1) · Aspirin (1) · Azithromycin (1) · Capsaicin (1) · Carbon Dioxide (1) · Citrulline (1) · Clopidogrel (1) · Ethanol (1)
GlaxoSmithKline (5) · Novartis Pharmaceuticals (2) · Patrick Murphy (2) · 5i Sciences, Inc. (1) · APR Applied Pharma Research s.a. (1) · AbbVie (1) · Abraham Edgar Gracia-Ramos (1) · Al-Azhar University (1) · Asklepion Pharmaceuticals, LLC (1) · AstraZeneca (1) · Australian National University (1) · Bayer (1) · Baylor College of Medicine (1) · Baylor Research Institute (1) · Beth Israel Deaconess Medical Center (1)
United States (34) · Italy (6) · United Kingdom (5) · Canada (4) · Germany (4) · Australia (3) · Denmark (3) · Brazil (2) · Chile (2) · Mexico (2) · Russia (2) · Sweden (2) · Argentina (1) · Belgium (1) · Egypt (1)
Abraham Edgar Gracia-Ramos, MD MSc (1) · Adrienne Randolph, MD (1) · Ajit Limaye, MD (1) · Amber U Luong, MD, PhD (1) · Ana Martins Valle (1) · Anders Perner, MD, PhD (1) · Boyd Taylor Thompson, MD (1) · Craig Weinert, MD (1) · Edward M. Weaver, MD, MPH (1) · Edward S Schulman, MD (1) · Elisa Perger, MD (1) · Ernest E Moore, MD (1)
PMID 31209698, PMID 22791092, PMID 23784924, PMID 23907810, PMID 26728475, PMID 27059469, PMID 27110692, PMID 27178892, PMID 27419080, PMID 28528348, PMID 28606907, PMID 28829877, PMID 29209510, PMID 29800001, PMID 29866165, PMID 30154874, PMID 30558653, PMID 30850876, PMID 30956804, PMID 31119695, PMID 31352795, PMID 31455384, PMID 31741746, PMID 32838109, PMID 32847626, PMID 33287790, PMID 33331622, PMID 33502773, PMID 34473343, PMID 34529182, PMID 34592318, PMID 35244208, PMID 35493119, PMID 36044317, PMID 36104613, PMID 36823164, PMID 37338154, PMID 37355270, PMID 37889107, PMID 38762798, PMID 38865147, PMID 39231898, PMID 39317833, PMID 39432177, PMID 39467285, PMID 41015199, PMID 41788496
2009 (1), 2019 (1), R01HL084139 (1), R01HL130881 (1), R21NR012795 (1), U01HL102547 (1), U10HD036790 (1), UG1HD021364 (1), UG1HD027851 (1), UG1HD027853 (1), UG1HD027880 (1), UG1HD027904 (1), UG1HD034216 (1), UG1HD040492 (1), UG1HD040689 (1)