7 terminated. 7 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Terminated 7 |
| Phase 2 | 3 | Terminated 3 |
Follow Primary Dysautonomias: new trials by email Literature Review of Primary Dysautonomias trials Research Report on Primary Dysautonomias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Orthostatic Intolerance After Bariatric Surgery Atomoxetine, Placebo - Orthostatic Intolerance | Phase 1 | Terminated | Vanderbilt University Medical Center | 10 | 2018-07-01 | 2024-09-27 |
| Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Droxidopa, Midodrine, Placebo - Autonomic Failure, Pure Autonomic Failure | Phase 1 | Terminated | Vanderbilt University Medical Center | 34 | 2016-09-01 | 2026-10-23 |
| Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS) Iron infusion, Normal saline infusion - Postural Orthostatic Tachycardia Syndrome | Phase 1 / Phase 2 | Terminated | Mayo Clinic | 3 | 2014-12-17 | 2017-11-17 |
| High Sodium Diet and External Abdominal Compression in POTS External automated abdominal binder - Postural Orthostatic Tachycardia Syndrome | Phase 1 | Terminated | Vanderbilt University | 13 | 2012-12-01 | 2017-01-18 |
| Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist Droxidopa, Atenolol, Placebos - Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance | Phase 1 / Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 8 | 2011-08-15 | 2017-05-18 |
| Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Losartan, Captopril, Placebo - Hypertension, Pure Autonomic Failure | Phase 1 | Terminated | Vanderbilt University | 12 | 2011-03-01 | 2018-08-24 |
| Augmenting Effects of L-DOPS With Carbidopa and Entacapone Droxidopa, Carbidopa, Entacapone - Parkinson Disease, Multiple System Atrophy | Phase 1 / Phase 2 | Terminated | National Institute of Neurological Disorders and Stroke (NINDS) | 14 | 2007-10-01 | 2014-07-17 |
Multiple System Atrophy (3) · Orthostatic Intolerance (3) · Postural Orthostatic Tachycardia Syndrome (3) · Parkinson Disease (2) · Pure Autonomic Failure (2) · Tachycardia (2) · Autonomic Nervous System Diseases (1) · Hypertension (1) · Hypotension, Orthostatic (1)
Nervous System Diseases (7) · Autonomic Nervous System Diseases (6) · Cardiovascular Diseases (4) · Basal Ganglia Diseases (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Movement Disorders (3) · Neurodegenerative Diseases (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Synucleinopathies (3) · Arrhythmias, Cardiac (2) · Cardiac Conduction System Disease (2)
Droxidopa (3) · Atenolol (1) · Atomoxetine Hydrochloride (1) · Captopril (1) · Carbidopa (1) · Ferric Oxide, Saccharated (1) · Losartan (1) · Midodrine (1) · Saline Solution (1) · Sodium Chloride (1) · Sugars (1) · entacapone (1)
Vanderbilt University (2) · Vanderbilt University Medical Center (2) · Beth Israel Deaconess Medical Center (1) · Mayo Clinic (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1)
United States (7)
Italo Biaggioni, MD (3) · Amie Jones, MD (1) · Cyndya Shiabao, M.D. (1) · David S Goldstein, M.D. (1) · Roy Freeman, MD (1)
R01HL059459 (1)