53 completed, 26 recruiting, 22 active not recruiting, 13 not yet recruiting. 64 Not applicable, 20 Phase 2, 9 Phase 1, 7 Early Phase 1, 4 Phase 4.
Follow this condition Literature Review of Postural Orthostatic Tachycardia Syndrome trials Research Report on Postural Orthostatic Tachycardia Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity breathing exercise training - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Virginia Commonwealth University | 12 | 2028-01-01 | 2026-09-16 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome Bilateral Sequential Stellate Ganglion Block - POTS - Postural Orthostatic Tachycardia Syndrome | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-10-01 | 2026-09-24 |
| aVNT in POTS - Pilot active aVNT vs. Sham - Postural Orthostatic Tachycardia Syndrome (POTS) | Not applicable | Not yet recruiting | University of Calgary | 30 | 2026-09-01 | 2026-05-01 |
| Low Dose Naltrexone Use in Patients With POTS Low Dose Naltrexone, Microcrystalline cellulose - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | University of Calgary | 80 | 2026-07-01 | 2026-05-01 |
| Presentation of Young Adults With and Without Joint Hypermobility Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) | Not yet recruiting | Clarkson University | 100 | 2026-06-20 | 2026-06-22 | |
| Beta-3 Enhanced Autonomic Therapy for POTS Mirabegron, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS) | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 36 | 2026-05-01 | 2026-05-13 |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-03-17 |
| Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome? Swimming, Cycling - ME/CFS, Long COVID | Not applicable | Suspended | Simon Fraser University | 50 | 2026-02-20 | 2026-03-30 |
| Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To measure levels of circulating monocyte/ T cell doublets after 28 days of Placebo treatment - Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS) | Phase 2 | Recruiting | Vanderbilt University Medical Center | 50 | 2025-12-18 | 2026-01-22 |
| Restoring Iron Deficiency in POTS Intravenous iron - POTS - Postural Orthostatic Tachycardia Syndrome | Phase 2 | Active not recruiting | Vanderbilt University Medical Center | 12 | 2025-11-24 | 2026-10-13 |
| Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations Screening - Clonal Mast Cell Disease, KIT D816V Mutation | Recruiting | Blueprint Medicines Corporation | 750 | 2025-10-17 | 2026-10-07 | |
| Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome Stellate ganglion block, Sham injection of saline, Ropivacaine - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Stanford University | 20 | 2025-10-13 | 2025-10-15 |
| Auto-immune Contribution in Symptom-based Sensory and Autonomic Disorders Questionnaire and Physical Exam, Nerve conduction studies, Microneurography - Postural Orthostatic Tachycardia Syndrome (POTS), Fibromyalgia (FM) | Not yet recruiting | King's College London | 250 | 2025-10-01 | 2025-05-28 | |
| Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome Low sodium oxybate (LXB), Placebo - Idiopathic Hypersomnia, POTS - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | Stanford University | 25 | 2025-10-01 | 2025-07-25 |
| Programming Aquatic Therapy for POTS Aquatic Occupational Therapy - Postural Orthostatic Tachycardia Syndrome (POTS) | Not applicable | Completed | California State University, Dominguez Hills | 5 | 2025-09-12 | 2026-04-03 |
| Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome. TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB), Sham TVNS + SDB - Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes | Not applicable | Not yet recruiting | Ali Kapan | 100 | 2025-09-01 | 2025-06-04 |
| Tragus Stimulation for POTS Treatment Transcutaneous auricular vagus nerve stimulation - Postural Orthostatic Tachycardia Syndrome (POTS) | Not applicable | Not yet recruiting | Aristotle University Of Thessaloniki | 24 | 2025-09-01 | 2025-09-09 |
| Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome. diaphragmatic breathing exercise, educational retraining - Orthostatic Hypotension, Heart Rate | Not applicable | Recruiting | Riphah International University | 44 | 2025-08-31 | 2026-05-11 |
Showing 20 of 134. Sign in to see all of them.
Orthostatic Intolerance (33) · Autonomic Nervous System Diseases (19) · Post-Acute COVID-19 Syndrome (16) · Tachycardia (13) · Primary Dysautonomias (9) · Syncope (9) · Syncope, Vasovagal (9) · Fatigue Syndrome, Chronic (7) · Fibromyalgia (7) · COVID-19 (6) · Ehlers-Danlos Syndrome (5) · Anxiety Disorders (4) · Mental Fatigue (4) · Amyotrophic Lateral Sclerosis (3)
Nervous System Diseases (132) · Primary Dysautonomias (125) · Autonomic Nervous System Diseases (115) · Orthostatic Intolerance (101) · Pathological Conditions, Signs and Symptoms (69) · Signs and Symptoms (52) · Neurologic Manifestations (45) · Pathologic Processes (37) · Disease Attributes (22) · Chronic Disease (21) · Cardiovascular Diseases (19) · Respiratory Tract Diseases (19) · Infections (18) · RNA Virus Infections (17) · Virus Diseases (17)
Saline Solution (9) · Sodium Chloride (6) · Ivabradine (5) · Propranolol (5) · Pyridostigmine Bromide (4) · Blood Specimen Collection (3) · Phenylephrine (3) · Vagus Nerve Stimulation (3) · Albumins (2) · Blood Pressure (2) · Droxidopa (2) · Ferric Oxide, Saccharated (2) · Isoproterenol (2) · Modafinil (2) · Restraint, Physical (2)
Vanderbilt University Medical Center (18) · Vanderbilt University (12) · University of Calgary (9) · New York Medical College (6) · Mayo Clinic (5) · Satish R. Raj (4) · Karolinska Institutet (3) · King's College London (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Nationwide Children's Hospital (3) · Stanford University (3) · Virginia Commonwealth University (3) · Brigham and Women's Hospital (2) · Cedars-Sinai Medical Center (2) · Genetic Disease Investigators (2)
United States (90) · Canada (11) · Germany (4) · Sweden (4) · Italy (3) · Belgium (2) · Pakistan (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Denmark (1) · Egypt (1) · Poland (1) · South Korea (1)
Satish R Raj, MD MSCI (10) · Italo Biaggioni, MD (6) · Alfredo J Gamboa, MD (4) · Cyndya Shibao, M.D (4) · Satish R Raj, MD, MSCI (3) · Franca Barbic, MD (2) · Julian M. Stewart, M.D., Ph.D. (2) · Satish Raj, MD, MSCI (2) · Stavros Stavrakis, MD (2) · Werner Z'Graggen, MD (2) · Alexandra Coates, PhD (1) · Alfredo Gamboa, MD (1) · Ali Kapan, PhD (1) · Amanda J Miller, Ph.D. (1) · Amie Jones, MD (1)
PMID 10037110, PMID 11018167, PMID 15710782, PMID 15911704, PMID 16943900, PMID 17709712, PMID 17951266, PMID 19687359, PMID 21062792, PMID 21266211, PMID 21906029, PMID 22247480, PMID 23283362, PMID 23434314, PMID 24002370, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24721800, PMID 24840763, PMID 25483980, PMID 25792354, PMID 26241226, PMID 26764413, PMID 29500811, PMID 30256820, PMID 31640632, PMID 32673517, PMID 33478652, PMID 33486983, PMID 33689063, PMID 33926653, PMID 34792683, PMID 35232225, PMID 35526605, PMID 35816681, PMID 36300662, PMID 36437696, PMID 37261636, PMID 37393658, PMID 37999672, PMID 39614865, PMID 40588382, PMID 40692561, PMID 41338488, PMID 41747483, PMID 42342403, PMID 462143, PMID 8423877
R01HL102387 (4), K23RR020783 (2), UL1RR024975 (2), 2017 (1), 5UL1TR000445-07 (1), P01HL056693 (1), P01NS044233 (1), R01HL059459 (1), R01HL071784 (1), R01HL128393 (1), R01HL142583 (1), R01HL163577 (1), R01HL166272 (1), R21NS094644 (1), R56HL142583 (1)