11 recruiting, 4 completed, 3 unknown, 2 not yet recruiting. 14 Not applicable, 3 Phase 2, 3 Phase 4, 2 Phase 3, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Pregabalin Combined With Educational and Behavioral Intervention for Bladder Pain Syndrome/Interstitial Cystitis Educational and Behavioral Management Program (EBMP), Pregabalin - Bladder Pain Syndrome, Pregabalin | Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-12-31 | 2026-08-07 |
| Effect of Pregabalin on Optic Nerve Sheath Diameter in Craniotomy Patients. Pregabalin, Placebo - Pregabalin, Optic Nerve Sheath Diameter Measurement | Not applicable | Active not recruiting | Benha University | 100 | 2026-05-25 | 2026-06-08 |
| Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome Pregabalin, Pregabalin + Amantadine, Pregabalin + Duloxetine - Amantadine, Duloxetine | Not applicable | Recruiting | Cairo University | 150 | 2026-02-21 | 2026-02-24 |
| Y-4 to Treat the Postherpetic Neuralgia Y-4 tables, Pregabalin - Postherpetic Neuralgia, Y-4 | Phase 2 | Recruiting | Neurodawn Pharmaceutical Co., Ltd. | 160 | 2026-02-02 | 2026-05-13 |
| Efficacy and Safety of Pregabalin/Tizanidine vs. Pregabalin in Patients With Fibromyalgia Pregabalin, Pregabalin with tizanidine - Fibromyalgia, Pregabalin | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 164 | 2026-01-30 | 2026-02-04 |
| Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery Placebo capsule, Melatonin capsule, Pregabalin capsule - Oral, Melatonin | Not applicable | Recruiting | Tanta University | 105 | 2026-01-17 | 2026-01-21 |
| The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia Pregabalin, Pregabalin with toludesvenlafaxine - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 384 | 2025-10-20 | 2025-11-17 |
| The Efficacy and Safety of Pregabalin and Crisugabalin in Patients With Fibromyalgia Pregabalin, Crisugabalin - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 1116 | 2025-09-30 | 2026-02-11 |
| The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia Pregabalin, Pregabalin with dexmedetomidine - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 400 | 2025-09-30 | 2025-11-28 |
| The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia Pregabalin, Pregabalin with venlafaxine - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 750 | 2025-09-20 | 2026-09-02 |
| The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia Pregabalin and venlafaxine concomitant therapy, Esketamine plus pregabalin and venlafaxine concomitant therapy - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 92 | 2025-09-15 | 2026-05-07 |
| The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With Fibromyalgia Pregabalin, Pregabalin with desvenlafaxine - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 384 | 2025-09-15 | 2025-11-17 |
| The Efficacy and Safety of Pregabalin and Mirogabalin in Patients With Fibromyalgia Mirogabalin, Pregabalin - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 674 | 2025-09-05 | 2026-06-25 |
| Adding Amantadine to Pregabalin on Occurrence of Post-thoracotomy Pain Syndrome Amantadine+ Pregabalin, Pregabalin - Amantadine, Pregabalin | Not applicable | Completed | Cairo University | 60 | 2023-12-01 | 2026-01-06 |
| Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery Oxycodone and Pregabalin, Oxycodone and placebo capsules, Pregabalin and NS - Chronic Post Operative Pain, Oxycodone | Not applicable | Unknown | Beijing Tiantan Hospital | 264 | 2023-10-24 | 2024-08-01 |
| Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting Pregabalin, Dexmedetomidine - Pregabalin, Delirium Treatment | Phase 4 | Recruiting | Tanta University | 70 | 2022-12-15 | 2025-06-25 |
| Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery Pregabalin, Dexmedetomidine - Pregabalin, Dexmedetomidine | Phase 4 | Completed | Tanta University | 60 | 2022-12-15 | 2025-01-07 |
| Preemptive Analgesia Combination of Celecoxib and Pregabalin in THA Single dose of celecoxib 400 mg and pregabalin 150 mg, Repeated dose of celecoxib 200 mg and pregabalin 75 mg, Placebo - Arthroplasty Complications, Analgetic | Phase 2 / Phase 3 | Unknown | Universitas Indonesia | 30 | 2022-10-01 | 2022-08-24 |
| Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects Pregabalin 25 MG, Placebo - Postoperative Pain, Pregabalin | Phase 4 | Unknown | Ajou University School of Medicine | 132 | 2022-10-01 | 2022-07-28 |
| Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms. S-ketamine and pregabalin, Normal saline and placebo capsule - Esketamine, Pregabalin | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 90 | 2021-12-01 | 2023-07-06 |
Showing 20 of 21. Sign in to see all of them.
Fibromyalgia (8) · Pain (6) · Pain, Postoperative (4) · Anxiety Disorders (1) · Brain Neoplasms (1) · Cystitis, Interstitial (1) · Delirium (1) · Drug-Related Side Effects and Adverse Reactions (1) · Empowerment (1) · Frailty (1) · Neuralgia, Postherpetic (1) · Postoperative Complications (1) · Somatoform Disorders (1) · Spinal Cord Neoplasms (1)
Pathological Conditions, Signs and Symptoms (13) · Nervous System Diseases (12) · Neurologic Manifestations (12) · Signs and Symptoms (12) · Neuromuscular Diseases (9) · Muscular Diseases (8) · Musculoskeletal Diseases (8) · Rheumatic Diseases (8) · Pain (5) · Pathologic Processes (5) · Mental Disorders (3) · Postoperative Complications (3) · Central Nervous System Diseases (2) · Central Nervous System Neoplasms (2) · Neoplasms (2)
Pregabalin (20) · Dexmedetomidine (3) · Esketamine (2) · Amantadine (1) · Celecoxib (1) · Desvenlafaxine Succinate (1) · Duloxetine Hydrochloride (1) · Melatonin (1) · Oxycodone (1) · Saline Solution (1) · Venlafaxine Hydrochloride (1) · mirogabalin (1) · tizanidine (1)
Beijing Tiantan Hospital (11) · Tanta University (3) · Cairo University (2) · Ajou University School of Medicine (1) · Benha University (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Neurodawn Pharmaceutical Co., Ltd. (1) · Universitas Indonesia (1)
China (11) · Egypt (6) · Canada (1)
Ruquan Han, M.D., Ph D. (2) · Andri MT Lubis (1) · Doha M Bakr, MD (1) · Emily G McDonald, MD, MSc (1) · Han-Dong Lee, Prof. (1) · Osama M Rehab, MD (1)
PMID 35820684, PMID 36841794, PMID 37349841, PMID 38501980, PMID 41800444, PMID 42170615, PMID 42170616, PMID 42642082