21 completed, 5 recruiting, 3 not yet recruiting, 3 unknown. 8 Phase 3, 8 Phase 4, 6 Not applicable, 6 Phase 1, 5 Phase 2.
Follow tizanidine: new trials by email Literature Review of tizanidine trials Research Report on tizanidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Postoperative Tizanidine Use in Pelvic Reconstructive Surgery: A Pilot Study Tizanidine, Standard-of-Care Therapy - Post Operative, Post Operative Analgesia | Phase 2 | Recruiting | Hartford Hospital | 186 | 2026-08-21 | 2026-09-21 |
| The Effect of Preoperative Administration of Oral Tizanidine on the Postoperative Pain and Sleep Quality Tizanidine, Placebo - The Effect of Preoperative Administration of Oral Tizanidine, Post Operative Pain | Not applicable | Recruiting | Tanta University | 68 | 2026-03-01 | 2026-09-02 |
| Efficacy and Safety of Pregabalin/Tizanidine vs. Pregabalin in Patients With Fibromyalgia Pregabalin, Pregabalin with tizanidine - Fibromyalgia, Pregabalin | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 164 | 2026-01-30 | 2026-02-04 |
| Bi-level Erector Spinae Plane Block and Pre-emptive Oral Tizanidine for Analgesia After Mastectomy Surgery Bilevel erector spinae plane block, Placebo Oral Capsule, tizanidine oral capsule - Mastectomy Patient | Not applicable | Completed | Mansoura University | 90 | 2025-07-15 | 2026-01-27 |
| Tizanidine and Acoustic Reflex Tizanidine - Reflex, Acoustic, Hearing | Not applicable | Completed | Uşak University | 48 | 2025-07-15 | 2026-05-07 |
| CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial Tizanidine, MI-Opioid Taper, Placebo - Chronic Pain, Back Pain | Phase 3 | Recruiting | Stanford University | 375 | 2024-12-05 | 2026-05-06 |
| Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose - Acute Low-back Pain, Muscle Spasm; Back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 136 | 2024-09-18 | 2026-01-09 |
| Effect of Tizanidine on Postoperative Urinary Retention After Sacrospinous Suspension Tizanidine - Postoperative Urinary Retention, Sacrospinous Vaginal Vault Suspension | Phase 3 | Completed | Endeavor Health | 20 | 2024-09-17 | 2025-11-24 |
| Tizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trial Tizanidine Hcl 4Mg Tab, Zolpidem Tartrate 10 mg - Depressive Disorder, Major | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2024-09-01 | 2024-03-12 |
| Effect of Neural Constraints on Movement in Stroke Tizanidine, Placebo - Stroke | Early Phase 1 | Recruiting | Northwestern University | 64 | 2024-08-23 | 2026-10-05 |
| Assess the Effect of Metaxalone 640 mg (M640) Compared to Tizanidine 8 mg on Truck Driving Ability and Cognition metaxalone m640 mg, tizanidine 8mg - Cognitive Impairment | Phase 4 | Completed | Primus Pharmaceuticals | 20 | 2024-04-29 | 2026-09-11 |
| Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen - Spinal Cord Injuries, Spinal Cord Injury | Early Phase 1 | Unknown | University of Mississippi Medical Center | 16 | 2024-03-01 | 2024-07-01 |
| Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine - Drug-Drug Interaction | Early Phase 1 | Recruiting | Indiana University | 60 | 2023-10-06 | 2026-08-20 |
| TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME） Tizanidine Hydrochloride, Tizanidine Hydrochloride Placebo - Migraine Without Aura, Migraine With Aura | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 189 | 2023-06-01 | 2024-08-01 |
| Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study Tizanidine - Tizanididne, Levobupicaine | Phase 4 | Completed | All India Institute of Medical Sciences | 64 | 2022-08-20 | 2026-01-09 |
| Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity Transcutaneous spinal stimulation at 30 Hz, Transcutaneous spinal stimulation at 75 Hz, Tizanidine - Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury | Not applicable | Active not recruiting | University of Mississippi Medical Center | 12 | 2022-07-13 | 2026-08-28 |
| Opioid-Free Pain Protocol After Shoulder Arthroplasty Celecoxib, Pregabalin, Tramadol - Shoulder Arthropathy, Shoulder Pain | Phase 4 | Active not recruiting | Henry Ford Health System | 83 | 2022-06-25 | 2026-02-10 |
| Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty TiZANidine 2 MG Oral Capsule - Pain, Postoperative | Not applicable | Unknown | Rothman Institute Orthopaedics | 240 | 2020-09-03 | 2020-10-05 |
| Gabapentin and Tizanidine for Insomnia in Chronic Pain Gabapentin, Placebo, Tizanidine - Insomnia Due to Medical Condition, Chronic Pain | Phase 2 | Completed | University of California, San Diego | 9 | 2020-07-29 | 2025-01-03 |
Showing 20 of 36. Sign in to see all of them.
Muscle Spasticity (6) · Chronic Pain (3) · Pain (3) · Pain, Postoperative (3) · Spasm (3) · Spinal Cord Injuries (3) · Back Pain (2) · Low Back Pain (2) · Migraine Disorders (2) · Multiple Sclerosis (2) · Opioid-Related Disorders (2) · Stroke (2) · Agnosia (1) · Arthritis (1) · Cognitive Dysfunction (1)
Acorda Therapeutics (2) · Dr. Reddy's Laboratories Limited (2) · University of Mississippi Medical Center (2) · All India Institute of Medical Sciences (1) · Ataturk University (1) · Bausch Health Americas, Inc. (1) · Beijing Tiantan Hospital (1) · Diskapi Teaching and Research Hospital (1) · Elan Pharmaceuticals (1) · Endeavor Health (1) · Express Specialty Pharmacy (1) · Hartford Hospital (1) · Henry Ford Health System (1) · Hoffmann-La Roche (1) · Icahn School of Medicine at Mount Sinai (1)
United States (18) · Canada (3) · Turkey (Türkiye) (3) · China (2) · Egypt (2) · Brazil (1) · Cyprus (1) · India (1) · Israel (1) · Mexico (1) · Romania (1) · Russia (1) · South Korea (1)
Benoit Girard, M.D (2) · Ali Ahiskalioglu, Ass.Prof. (1) · Alison Oliveto, Ph.D. (1) · Amany H ELDeeb, MD (1) · Andrew Bishara, MD (1) · Arnon Karni, MD (1) · Claudia Paya Ten, MD (1) · David Simpson, MD (1) · Dilek Yazicioglu, Dr (1) · Doina Rosu, MD (1) · Elena Tunitsky, MD (1) · Farit Khabirov, MD, DSc, Prof (1) · Herbert Henney, PharmD (1) · J C Lukban, DO (1)
PMID 26555871, PMID 11130605, PMID 12269398, PMID 16038812, PMID 18977811, PMID 20223444, PMID 22590713, PMID 23731663, PMID 24524844, PMID 27521884, PMID 29468508, PMID 30353868, PMID 30496104, PMID 30879893, PMID 30955985, PMID 32430657, PMID 38529017, PMID 41687037, PMID 41854462, PMID 42170616, PMID 8080219, PMID 8646957
R01DA010017 (1), R01HD039343 (1), R35GM145383 (1), UL1TR000100 (1)