48 completed, 12 unknown, 2 recruiting, 2 withdrawn. 65 Phase 3, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 65 | Completed 48, Unknown 12, Recruiting 2, Withdrawn 2, Terminated 1 |
| Phase 2 | 12 | Completed 9, Unknown 2, Recruiting 1 |
Follow Postoperative Nausea and Vomiting: new trials by email Literature Review of Postoperative Nausea and Vomiting trials Research Report on Postoperative Nausea and Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients Aprepitant 40mg, Placebo - Nausea and Vomiting, Postoperative, Prevention | Phase 3 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 260 | 2026-02-27 | 2026-08-27 |
| Comparison of Dexmedetomidine and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy Dexamedomedine, Dexamethasone - Postoperative Nausea and Vomiting | Phase 3 | Completed | Patel Hospital, Pakistan | 68 | 2025-06-01 | 2026-02-23 |
| MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children Melatonin, Isotonic sodium chloride solution - Emergence Delirium | Phase 3 | Recruiting | Arash Afshari | 676 | 2025-01-21 | 2026-08-18 |
| Oral Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy Dexamethasone Oral, Dexamethasone - Postoperative Nausea and Vomiting | Phase 3 | Unknown | Mansoura University | 814 | 2024-03-04 | 2024-03-12 |
| An Evaluation the Effect of Superhydration Versus Dextrose 10% for Prevention of Post Operative Nausea and Vomiting After Laparoscopic Cholecystectomy (Prospective Randomised Controlled Study) ringer lactate (20ml/kg), Dextrose 10% - Postoperative Nausea and Vomiting (PONV) | Phase 3 | Completed | Ain Shams University | 204 | 2024-02-25 | 2025-02-26 |
| Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting Aprepitant Injection, Aprepitant Injection Placebo - Postoperative Nausea and Vomiting | Phase 3 | Completed | Qilu Pharmaceutical (Hainan) Co., Ltd. | 518 | 2024-02-02 | 2025-04-23 |
| Study of Intravenous Amisulpride for Prophylaxis of Post-operative Nausea and Vomiting (PONV) in Pediatric Patients Amisulpride Injection, Dexamethasone - Nausea and Vomiting, Postoperative | Phase 2 / Phase 3 | Completed | Acacia Pharma Ltd | 453 | 2024-01-18 | 2025-06-25 |
| Intraoperative Autonomic Neural Blockade Local anesthetic injection Bupivacaine plus dexamethasone, Local anesthetic injection bupivacainde plus dexamethasone plus a colloid, Local anesthetic injection bupivacaine plus clonidine - Pain, Postoperative, Nausea, Postoperative | Phase 3 | Unknown | Universidad Simón Bolívar | 150 | 2023-12-02 | 2023-11-18 |
| Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy At-night Dexamethasone, At-induction Dexamethasone - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 2 / Phase 3 | Completed | Mansoura University | 60 | 2023-10-08 | 2024-01-25 |
| Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy normal Saline, Dexamethasone, Dexmedetomidine - Laparoscopic Cholecystectomy, Postoperative Nausea and Vomiting | Phase 3 | Completed | Al-Azhar University | 120 | 2023-08-10 | 2025-06-18 |
| Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data Neuraxial Analgesia, Regional Block 1: Paravertebral, Perphenazine - Perioperative Optimization | Phase 3 | Completed | Jennifer Holder-Murray | 3395 | 2023-05-15 | 2026-05-28 |
| A Comparison of the Efficacy of Amisulpride and Placebo in the Prevention of PONV in Patients at Moderate-to-high Risk of PONV. Amisulpride, Amisulpride Placebo - PONV | Phase 3 | Unknown | Qilu Pharmaceutical (Hainan) Co., Ltd. | 516 | 2023-04-29 | 2023-04-21 |
| Ondansetron and Gabapentin in Preventing Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy Ondansetron 8mg, Gabapentin - Post Operative Nausea and Vomiting, Sleeve Gastrectomy | Phase 3 | Completed | Tanta University | 100 | 2022-10-01 | 2025-04-17 |
| THRIVE Feasibility Trial Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent - Surgery--Complications, Anesthesia Complication | Phase 3 | Completed | Washington University School of Medicine | 300 | 2022-09-29 | 2023-11-24 |
| Baclofen in Preventing Postoperative Nausea and Vomiting After Bariatric Surgery Baclofen Tablets - Postoperative Nausea and Vomiting, Laparoscopic Sleeve Gastrectomy | Phase 2 / Phase 3 | Completed | Tanta University | 100 | 2022-08-22 | 2025-04-22 |
| Effect of Palonosetron, Ondansetron and Dexamethasone in the Prevention of Postoperative Nausea and Vomiting Ondansetron+Dexamethasone, Palonosetron+Dexamethasone, Dexamethasone - Laparoscopic Surgery, Pediatrics | Phase 3 | Unknown | Selcuk University | 66 | 2022-06-01 | 2022-06-30 |
| The Effect of Oxygen Given to Patients in the Postoperative Period on Nausea and Vomiting oxygen - Oxygen, Postoperative Nausea and Vomiting | Phase 3 | Unknown | Selcuk University | 111 | 2022-05-03 | 2020-10-22 |
| Supplemental Perioperative Intravenous Crystalloids for Postoperative Nausea and Vomiting in Children Undergoing Oncological Surgery Ringer's Lactate, normal Saline - Nausea and Vomiting, Postoperative | Phase 2 / Phase 3 | Completed | Alexandria University | 100 | 2022-01-10 | 2022-12-20 |
| The PREVENT AGITATION Trial II - Children ≤1 Year Clonidine, Sodium chloride - Emergence Delirium | Phase 2 / Phase 3 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 336 | 2021-10-25 | 2026-08-12 |
| Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy Dexamethasone 4 Mg/mL Injectable Solution, NaCl 0.9% - Pain, Postoperative Nausea | Phase 3 | Unknown | Balgrist University Hospital | 60 | 2021-07-16 | 2024-08-12 |
Showing 20 of 65. Sign in to see all of them.
Pain, Postoperative (14) · Vomiting (12) · Nausea (6) · Agnosia (4) · Emergence Delirium (3) · Obesity, Morbid (2) · Pain (2) · Adenomyosis (1) · Anxiety Disorders (1) · Breast Neoplasms (1) · Depression (1) · Fatigue (1) · Hip Dislocation (1) · Hypercapnia (1)
Pathologic Processes (65) · Pathological Conditions, Signs and Symptoms (65) · Signs and Symptoms (65) · Signs and Symptoms, Digestive (65) · Postoperative Complications (64) · Nausea (59) · Vomiting (53) · Neurologic Manifestations (16) · Pain (14) · Nervous System Diseases (8) · Neurobehavioral Manifestations (7) · Mental Disorders (4) · Perceptual Disorders (4) · Confusion (3) · Delirium (3)
Dexamethasone (19) · Sodium Chloride (8) · Aprepitant (6) · Ondansetron (6) · Saline Solution (6) · Palonosetron (5) · Amisulpride (3) · Calcium Dobesilate (3) · Gabapentin (3) · Granisetron (3) · Clonidine (2) · Dexmedetomidine (2) · Ringer's Lactate (2) · Ropivacaine (2) · casopitant (2)
Acacia Pharma Ltd (6) · Assiut University (3) · Balgrist University Hospital (2) · GlaxoSmithKline (2) · Helsinn Healthcare SA (2) · Instituto Mexicano del Seguro Social (2) · Mansoura University (2) · Merck Sharp & Dohme LLC (2) · Qilu Pharmaceutical (Hainan) Co., Ltd. (2) · Selcuk University (2) · Tanta University (2) · Ain Shams University (1) · Al-Azhar University (1) · Alexandria University (1) · Arash Afshari (1)
United States (14) · Egypt (10) · France (8) · Germany (7) · Canada (4) · Denmark (4) · Turkey (Türkiye) (4) · Ireland (3) · Pakistan (3) · Russia (3) · Switzerland (3) · Brazil (2) · China (2) · Czechia (2) · Hong Kong (2)
Alejandro Gonzalez-Ojeda, M.D., Ph.D. (2) · Moataz M Emara, MD, EDAIC (2) · Patrick Zingg, MD (2) · Alex Sia (1) · Arash Afshari, PhD (1) · Arash L Afshari, MD, PhD (1) · Arne Johan Norheim, MD Doctor phD (1) · Aya H. M. Ahmad, Assistant professor, MD (1) · Aya Moussa (1) · Daniel I Sessler, M.D. (1) · Elyad Davidson, M.D. (1) · Faruk Cicekci (1) · Ferda Yaman, assist prof (1)
PMID 21182781, PMID 23887247, PMID 24015953, PMID 25037960, PMID 25563879, PMID 25900659, PMID 26032041, PMID 27762434, PMID 31094774, PMID 31538078, PMID 34041090, PMID 36877132, PMID 37068889, PMID 37423834, PMID 38154902, PMID 38456291, PMID 40032662, PMID 40041104, PMID 40460271, PMID 41062989, PMID 41950401, PMID 41981586, PMID 42325096, PMID 42637866
2014 (1), 2019 (1)