41 completed, 10 unknown, 3 recruiting, 2 active not recruiting. 58 Phase 2, 12 Phase 3, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 58 | Completed 41, Unknown 10, Recruiting 3, Active not recruiting 2, Terminated 2 |
| Phase 3 | 12 | Completed 9, Unknown 2, Recruiting 1 |
| Phase 1 | 6 | Completed 5, Active not recruiting 1 |
Follow Postoperative Nausea and Vomiting: new trials by email Literature Review of Postoperative Nausea and Vomiting trials Research Report on Postoperative Nausea and Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Midazolam Adjunct Therapy for Prevention of PONV in Gynecological Laparoscopy Midazolam 0.05 mg/kg IV as adjunct to dexamethasone and ondansetron for PONV prevention - Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery | Phase 2 | Completed | Hameed Latif Hospital, Lahore | 300 | 2025-12-02 | 2026-06-25 |
| Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery Encapsulated amisulpride 50 mg (matched for color, weight, smell and size), Encapsulated placebo (matched for color, weight, smell and size) - Post Operative Nausea and Vomiting (PONV) | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 276 | 2025-04-10 | 2026-09-09 |
| Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery Aprepitant, Placebo - Spinal Fusion, Nausea and Vomiting, Postoperative | Phase 2 | Recruiting | IWK Health Centre | 100 | 2025-03-17 | 2026-04-27 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive - Postoperative Pain, Nausea and Vomiting, Postoperative | Phase 1 / Phase 2 | Active not recruiting | University of Arizona | 100 | 2024-10-10 | 2026-02-13 |
| PONV Prevention Via Percutaneous Nerve Electrical Stimulation on PC6 electrical stimualtion via EmeTerm bracelet, antimetic drugs（ dexamethasone，ondansetron） - Postoperative Nausea and Vomiting | Phase 2 | Completed | Peking Union Medical College Hospital | 326 | 2024-02-05 | 2026-06-17 |
| Study of Intravenous Amisulpride for Prophylaxis of Post-operative Nausea and Vomiting (PONV) in Pediatric Patients Amisulpride Injection, Dexamethasone - Nausea and Vomiting, Postoperative | Phase 2 / Phase 3 | Completed | Acacia Pharma Ltd | 453 | 2024-01-18 | 2025-06-25 |
| Dexamethasone at Night vs at Induction on PONV After Laparoscopic Cholecystectomy At-night Dexamethasone, At-induction Dexamethasone - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 2 / Phase 3 | Completed | Mansoura University | 60 | 2023-10-08 | 2024-01-25 |
| The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery Olanzapine, Placebo - Postoperative Nausea and Vomiting | Phase 2 | Completed | Yale University | 398 | 2023-06-26 | 2026-07-16 |
| Prophylaxis Against Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy Ondansetron 4mg + dexmedetomidine 0.5 ug/kg + normal saline ., Ondansetron 4mg + dexamethasone 8mg + normal saline. - Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy | Phase 2 | Unknown | Tanta University | 70 | 2022-09-15 | 2023-08-30 |
| A 6 Months Double Blind Trial to Prevent PONV in Laparoscopic Cholecystectomy Oral Capsule pregapalin, laparoscope device - Postoperative Nausea and Vomiting | Phase 2 | Unknown | Al Safwa University College | 100 | 2022-09-01 | 2022-09-06 |
| Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery pantoprazole, Placebo - Postoperative Nausea and Vomiting | Phase 2 | Recruiting | United States Naval Medical Center, Portsmouth | 132 | 2022-08-26 | 2025-05-21 |
| Baclofen in Preventing Postoperative Nausea and Vomiting After Bariatric Surgery Baclofen Tablets - Postoperative Nausea and Vomiting, Laparoscopic Sleeve Gastrectomy | Phase 2 / Phase 3 | Completed | Tanta University | 100 | 2022-08-22 | 2025-04-22 |
| Supplemental Perioperative Intravenous Crystalloids for Postoperative Nausea and Vomiting in Children Undergoing Oncological Surgery Ringer's Lactate, normal Saline - Nausea and Vomiting, Postoperative | Phase 2 / Phase 3 | Completed | Alexandria University | 100 | 2022-01-10 | 2022-12-20 |
| The PREVENT AGITATION Trial II - Children ≤1 Year Clonidine, Sodium chloride - Emergence Delirium | Phase 2 / Phase 3 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 336 | 2021-10-25 | 2026-08-12 |
| Olanzapine for the Prevention of Postoperative Nausea and Vomiting Placebo, 5 mg Olanzapine Tablets, 10 mg Olanzapine Tablets - Postoperative Nausea | Phase 1 / Phase 2 | Completed | Amani Hassan Abdel-Wahab | 132 | 2021-03-15 | 2023-03-09 |
| The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy. Dexamethasone 24mg Solution for Injection, Saline Solution for Injection - Dexamethasone, Hip Dysplasia | Phase 2 / Phase 3 | Completed | Odense University Hospital | 90 | 2020-11-12 | 2024-04-02 |
| A Study of TAK-951 to Stop Adults Getting Nausea and Vomiting After Planned Surgery TAK-951, Ondansetron, Ondansetron Placebo - Postoperative Nausea and Vomiting (PONV) | Phase 2 | Completed | Takeda | 89 | 2020-10-20 | 2023-04-21 |
| Adding Nalbuphine for Control of Intrathecal Morphine Pruritus Morphine 10 MG/ML, Nalbuphine Hydrochloride 10 MG/ML - Pruritus, Pain, Postoperative | Phase 2 | Unknown | Minia University | 70 | 2020-10-15 | 2021-03-01 |
| Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting Granisetron 1 Mg/mL Intravenous Solution And Dexamethasone 4mg, Granisetron 1 Mg/mL Intravenous Solution - PONV | Phase 2 | Unknown | Universiti Sains Malaysia | 126 | 2020-10-01 | 2020-09-30 |
Showing 20 of 58. Sign in to see all of them.
Vomiting (18) · Nausea (12) · Pain, Postoperative (12) · Abdominal Pain (1) · Agnosia (1) · Anxiety Disorders (1) · Breast Neoplasms (1) · Colonic Neoplasms (1) · Constipation (1) · Delayed Emergence from Anesthesia (1) · Dizziness (1) · Emergence Delirium (1) · Hip Dislocation (1) · Neoplasms (1)
Pathologic Processes (58) · Pathological Conditions, Signs and Symptoms (58) · Postoperative Complications (58) · Signs and Symptoms (58) · Signs and Symptoms, Digestive (58) · Nausea (46) · Vomiting (40) · Neurologic Manifestations (14) · Pain (13) · Body Weight (2) · Digestive System Diseases (2) · Mental Disorders (2) · Musculoskeletal Diseases (2) · Neoplasms (2) · Neoplasms by Site (2)
Dexamethasone (14) · Ondansetron (10) · Saline Solution (7) · Calcium Dobesilate (5) · Olanzapine (4) · Aprepitant (3) · Sodium Chloride (3) · Dexmedetomidine (2) · Granisetron (2) · Ringer's Lactate (2) · ramosetron (2) · vestipitant (2) · Absorptiometry, Photon (1) · Acetaminophen (1) · Acupuncture Therapy (1)
Acacia Pharma Ltd (3) · Assiut University (3) · GlaxoSmithKline (3) · Instituto do Cancer do Estado de São Paulo (3) · National Research Centre of Complementary and Alternative Medicine, Norway (2) · Tanta University (2) · University Hospital, Geneva (2) · Accenture (1) · Al Safwa University College (1) · Alexandria University (1) · Amani Hassan Abdel-Wahab (1) · Campus Bio-Medico University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Eisai Inc. (1) · Hadassah Medical Organization (1)
United States (18) · Egypt (9) · Canada (6) · Germany (4) · Brazil (3) · Denmark (3) · France (3) · Norway (3) · Switzerland (3) · Australia (2) · Belgium (2) · Hungary (2) · Israel (2) · Italy (2) · Pakistan (2)
Roger Chammas (2) · Aaron P Hong, MD, FRCPC (1) · Amani H Abdel-wahab, MD (1) · Andrea Myers, MD (1) · Angela M Sousa, MD, MsC, PhD (1) · Arash Afshari, PhD (1) · Arne Johan Norheim, MD Doctor phD (1) · Arne Johan Norheim, PhD (1) · Aya Moussa (1) · Casey Timmerman, DO (1) · Christoph Czarnetzki, MD (1) · Daniel Bertrand, PhD (1) · David R. Drover, MD (1) · Dr Asma A Salam, MBBS, FCPS (1)
PMID 16846542, PMID 17513629, PMID 17885699, PMID 19092351, PMID 19617379, PMID 22096279, PMID 22546895, PMID 23872464, PMID 23904932, PMID 25127659, PMID 25488303, PMID 25670522, PMID 25885838, PMID 27829428, PMID 28160217, PMID 31303716, PMID 31862004, PMID 32229754, PMID 3354872, PMID 34799501, PMID 36877132, PMID 39313286, PMID 40460271, PMID 41981586, PMID 42160634, PMID 7986507
2019 (1)