203 completed, 36 unknown, 29 terminated, 24 recruiting. 175 Not applicable, 44 Phase 2, 21 Phase 4, 19 Phase 1, 19 Phase 3.
Follow Post-Traumatic Stress Disorder: new trials by email Literature Review of Post-Traumatic Stress Disorder trials Research Report on Post-Traumatic Stress Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE) - Alcohol Problems, Post-Traumatic Stress Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 29 | 2028-07-03 | 2025-11-19 |
| MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First Responders MDMA - Post-Traumatic Stress Disorder, Adjustment Disorders | Phase 2 | Not yet recruiting | Nautilus Sanctuary | 30 | 2026-10-01 | 2026-05-05 |
| The Effects of Trauma-informed Care Organization on Birth Professionals and Women's Experiences of Trauma. trauma-informed care training - Post-Traumatic Stress Disorder, Psychological Trauma | Not applicable | Not yet recruiting | Tarsus University | 345 | 2026-09-30 | 2026-09-16 |
| Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot Study Continuous wearable physiological monitoring (EmbracePlus, Empatica), Ketamine-assisted therapy (independently arranged), Structured pre- and post-session interviews - Post-Traumatic Stress Disorder | Not yet recruiting | Adriaan Dirk van der Wart | 5 | 2026-07-15 | 2026-05-29 | |
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| Recovering Sleep After Trauma Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT) - Post-traumatic Stress Disorder | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 20 | 2026-04-30 | 2026-10-29 |
| Sensory Motor Arousal Regulation Treatment (SMART) Study SMART - PTSD, Post-traumatic Stress Disorder | Not applicable | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 80 | 2026-04-15 | 2026-04-22 |
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Progressive Muscle Relaxation Training in Post-traumatic Stress Disorder in Disasters progressive muscle relaxation training - Post-traumatic Stress Disorder | Not applicable | Completed | Bitlis Eren University | 44 | 2025-09-02 | 2026-04-06 |
| Aerobic Exercise Intervention for PTSD Symptoms and Sleep Quality After Earthquake Moderate-Intensity Aerobic Exercise Program - Post-Traumatic Stress Disorder, Sleep Disturbance | Not applicable | Completed | Malatya Turgut Ozal University | 82 | 2025-09-01 | 2026-03-17 |
| Comparative Efficacy of Cognitive Behavioral and Mindfulness Therapies in Reducing Post-Traumatic Stress Disorder Among Interpersonal Violence Survivors Cognitive Behavioral Therapy (CBT), Mindfulness-Based Therapy (MBT), Psychoeducation - Post-traumatic Stress Disorder (PTSD), Post-Traumatic Stress Disorder | Not applicable | Active not recruiting | GIFT University | 60 | 2025-08-27 | 2026-09-03 |
| Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder Propofol - PTSD, Post-traumatic Stress Disorder | Phase 2 | Recruiting | Stanford University | 42 | 2025-07-21 | 2026-10-02 |
| Experience of Staying in Intensive Care and Impact on Quality of Life Post-traumatic Stress Disorder | Recruiting | University Hospital, Strasbourg, France | 40 | 2025-06-23 | 2026-01-14 | |
| Improving Sleep in Veterans With the Polytrauma Clinical Triad Morning Bright Light Therapy, Negative Ion Generator - Traumatic Brain Injury, Post-traumatic Stress Disorder | Not applicable | Recruiting | VA Office of Research and Development | 96 | 2025-05-01 | 2026-06-29 |
| Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico Trauma Focused Cognitive Behavioral Therapy - Post-Traumatic Stress Disorder | Not applicable | Recruiting | Medical University of South Carolina | 80 | 2025-04-01 | 2026-10-26 |
| Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder Psilocybin - Post-Traumatic Stress Disorder | Phase 1 | Withdrawn | Johns Hopkins University | 2025-01-01 | 2024-01-05 | |
| Pivotal Trial of SAT-014 for Trauma and Stressor-Related Disorder Symptoms SAT014, Control - Post-traumatic Stress Disorder, Adjustment Disorders | Not applicable | Completed | S-Alpha Therapeutics, Inc. | 110 | 2024-12-09 | 2025-08-05 |
| MDMA-assisted Massed Prolonged Exposure for PTSD 3,4 Methylenedioxymethamphetamine, Prolonged Exposure - Post-Traumatic Stress Disorder | Phase 3 | Active not recruiting | Healing Breakthrough | 20 | 2024-10-25 | 2026-08-26 |
| Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors Blueprint, Education program - Depression, Anxiety | Not applicable | Recruiting | Duke University | 400 | 2024-10-15 | 2026-07-23 |
| Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors Written Exposure Therapy, Unemotional Writing - Post-traumatic Stress Disorder | Not applicable | Completed | University of North Carolina, Chapel Hill | 30 | 2024-09-23 | 2026-03-16 |
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Stress Disorders, Post-Traumatic (319) · Anxiety Disorders (50) · Depression (48) · Wounds and Injuries (23) · Brain Injuries, Traumatic (16) · Depressive Disorder, Major (15) · Substance-Related Disorders (15) · Alcoholism (12) · Combat Disorders (8) · Generalized Anxiety Disorder (8) · Panic Disorder (8) · Psychological Well-Being (8) · Stress Disorders, Traumatic (8) · Brain Concussion (7) · Mental Disorders (7)
Trauma and Stressor Related Disorders (316) · Mental Disorders (312) · Stress Disorders, Traumatic (311) · Behavior (68) · Behavioral Symptoms (54) · Nervous System Diseases (39) · Chemically-Induced Disorders (28) · Pathological Conditions, Signs and Symptoms (27) · Wounds and Injuries (27) · Central Nervous System Diseases (23) · Trauma, Nervous System (23) · Brain Diseases (22) · Brain Injuries (21) · Craniocerebral Trauma (21) · Mood Disorders (19)
Cognitive Behavioral Therapy (14) · Therapeutics (12) · Eye Movement Desensitization Reprocessing (9) · Sertraline (7) · Exercise (6) · Propranolol (5) · Neurofeedback (4) · Paroxetine (4) · Transcranial Magnetic Stimulation (4) · Autogenic Training (3) · Early Intervention, Educational (3) · Implosive Therapy (3) · Ketamine (3) · N-Methyl-3,4-methylenedioxyamphetamine (3) · Quetiapine Fumarate (3)
VA Office of Research and Development (26) · US Department of Veterans Affairs (12) · Emory University (7) · Assistance Publique - Hôpitaux de Paris (6) · Duke University (5) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (5) · Massachusetts General Hospital (5) · University of California, Los Angeles (5) · University of Texas at Austin (5) · Creighton University (4) · NYU Langone Health (4) · Norwegian Center for Violence and Traumatic Stress Studies (4) · University Hospital, Lille (4) · University of California, San Francisco (4) · University of Pennsylvania (4)
United States (195) · France (27) · Canada (23) · Israel (8) · Germany (6) · Norway (6) · United Kingdom (6) · Turkey (Türkiye) (4) · Australia (3) · Pakistan (3) · Sweden (3) · Finland (2) · Italy (2) · Netherlands (2) · Poland (2)
Frederick Petty, MD, PhD (3) · Charles Marmar, MD (2) · Douglas F. Zatzick, MD (2) · Edna B. Foa, PhD (2) · Emmanuel Lagarde, PhD (2) · Irina Esterlis, PhD (2) · Jonathan Davidson, M.D. (2) · Joseph Zohar, MD (2) · Margaret McKinnon, PhD (2) · Marylene Cloitre, PhD (2) · Melissa B Jones, MD (2) · Patricia A. Resick, PhD (2) · Ruth A Lanius, MD, PhD (2) · Ruth Lanius, MD, PhD (2)
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P50MH058911 (2), R01MH051509 (2), 1UF1MH121954 (1), 2016 (1), I01RX000304 (1), I01RX003382 (1), I01RX004822 (1), I21RX002893 (1), IK2CX002363-01A1 (1), IK2RX000949 (1), K01TW012180 (1), K23GM068842 (1), P20MH068450 (1), P30CA013330 (1), P50MH077928 (1)