12 completed, 8 unknown, 3 terminated, 2 recruiting. 28 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 28 | Completed 12, Unknown 8, Terminated 3, Recruiting 2, Withdrawn 2, Not yet recruiting 1 |
Follow Pleural Diseases: new trials by email Literature Review of Pleural Diseases trials Research Report on Pleural Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VATS or Intrapleural Enzymatic Therapy for Patients With Empyema. VATS group, IET - Empyema, Pleural, Pleural Infections | Phase 4 | Recruiting | Amsterdam UMC | 164 | 2026-10-01 | 2026-10-26 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily - Pleural Infection Bacterial, Pleural Infections | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 270 | 2025-09-11 | 2026-09-29 |
| Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion thoracoscope - Malignant Pleural Effusions (Mpe)- Pleurodesis, Pleurodesis | Phase 4 | Completed | Mohamed Sabry | 60 | 2024-09-01 | 2024-12-20 |
| Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis lidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis. - Pleural Effusion | Phase 4 | Unknown | Assiut University | 118 | 2023-01-01 | 2023-08-09 |
| Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Diclofenac, Placebo - Pleural Neoplasms, Aspiration, Respiratory | Phase 4 | Unknown | Assiut University | 100 | 2021-11-01 | 2021-11-16 |
| Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis Cathflo Activase, Talc Slurry Pleurodesis - Pleural Effusion | Phase 4 | Completed | Memorial Healthcare System | 27 | 2021-06-15 | 2025-06-08 |
| Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion Talc - Malignant Pleural Effusion | Phase 4 | Terminated | Duke University | 4 | 2021-03-18 | 2023-09-28 |
| A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation - Pleural Effusion, Malignant, Pleural Mesothelioma | Phase 4 | Unknown | Mohamed Reda Ashour | 40 | 2020-01-15 | 2021-10-14 |
| Management of Pleural Space Infections Intrapleural Medications, Surgery, Pleural Sampling - Empyema, Pleural, Parapneumonic Effusion | Phase 4 | Completed | Swedish Medical Center | 26 | 2019-04-01 | 2022-11-22 |
| Betadine Pleurodesis Via Tunneled Pleural Catheters Povidone-Iodine - Pleural Effusion, Pleurodesis | Phase 4 | Withdrawn | Yale University | 2018-07-01 | 2019-01-11 | |
| Diaphragmatic Resection And Gynecological Ovarian Neoplasm thoracic Drain Tube 24 Fr. - Ovarian Cancer | Phase 4 | Completed | Catholic University of the Sacred Heart | 88 | 2018-03-20 | 2020-05-22 |
| Fibrinolysis Compared to Thoracoscopy for Pleural Infection tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy - Pleural Infection, Empyema | Phase 4 | Completed | Tulane University | 32 | 2017-11-01 | 2021-02-04 |
| Fibrinolytic Therapy Versus Medical Thoracoscopy Chest thoracoscopy, Chest fibrinolytic therapy, tPA - Pleural Diseases | Phase 4 | Completed | University of Florida | 5 | 2017-09-14 | 2024-02-20 |
| Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital streptokinase, MESNA (2-mercaptoethane sulfonate Na), Medical thoracoscopy - Pleural Effusion | Phase 4 | Unknown | Assiut University | 100 | 2017-08-01 | 2017-06-06 |
| Early Intrapleural TPA Instillation Versus Late early tPA and DNase - Tissue Plasminogen Activator | Phase 4 | Withdrawn | Prisma Health-Midlands | 2017-02-17 | 2025-02-21 | |
| Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis Questionnaires, Fentanyl Patch, Fentanyl (IV) - Advanced Cancers, Malignant Pleural Effusions | Phase 4 | Terminated | M.D. Anderson Cancer Center | 3 | 2016-04-27 | 2019-08-07 |
| Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Ketotifen, Placebo - Dengue Fever, Pleural Effusion | Phase 4 | Unknown | National University Hospital, Singapore | 110 | 2015-03-01 | 2016-02-04 |
| Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Cefazolin, saline - Pleural Effusion, Pleurisy | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 100 | 2015-01-01 | 2017-01-18 |
| Duration of Antibiotic Therapy in Community - Acquired Pneumonia Discontinuation of antibiotic therapy - Pneumonia, Bronchopneumonia | Phase 4 | Unknown | University of Milan | 892 | 2012-01-01 | 2014-01-03 |
Showing 20 of 28. Sign in to see all of them.
Pleural Effusion (12) · Pleural Effusion, Malignant (9) · Empyema, Pleural (7) · Pneumothorax (5) · Empyema (4) · Lung Neoplasms (4) · Pleural Neoplasms (3) · Respiratory Aspiration (2) · Bronchiolitis Obliterans Syndrome (1) · Bronchopneumonia (1) · Bronchopulmonary Dysplasia (1) · Carcinoma, Non-Small-Cell Lung (1) · Community-Acquired Pneumonia (1) · Dengue (1)
Respiratory Tract Diseases (28) · Neoplasms by Site (13) · Neoplasms (12) · Respiratory Tract Neoplasms (12) · Thoracic Neoplasms (12) · Infections (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Respiratory Tract Infections (9) · Suppuration (9) · Inflammation (8) · Pleural Neoplasms (8) · Lung Diseases (7) · Pleural Effusion (7)
Tissue Plasminogen Activator (4) · Deoxyribonucleases (2) · Sodium Chloride (2) · dornase alfa (2) · Anesthesia, General (1) · Cefazolin (1) · Clindamycin (1) · Cryotherapy (1) · Diclofenac (1) · Doxycycline (1) · Drug Delivery Systems (1) · Fentanyl (1) · Insure Cement (1) · Ketotifen (1) · Lidocaine (1)
Assiut University (3) · Duke University (2) · Amsterdam UMC (1) · Beijing Haidian Hospital (1) · CSA Medical, Inc. (1) · Catholic University of the Sacred Heart (1) · Dartmouth-Hitchcock Medical Center (1) · Grupo de Pesquisa em Pleura e Oncologia Toracica (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · M.D. Anderson Cancer Center (1) · Memorial Healthcare System (1) · Mohamed Reda Ashour (1) · Mohamed Sabry (1) · National University Hospital, Singapore (1) · Novartis Pharmaceuticals (1)
United States (12) · Egypt (3) · Brazil (2) · Italy (2) · China (1) · India (1) · Netherlands (1) · Singapore (1) · Spain (1) · Turkey (Türkiye) (1)
Ahmed F Koraitim, MD (1) · Ashley L St John (1) · David Ost, MD (1) · Fayez Kheir, MD, MSc (1) · Gordon Downie, M.D., Ph.D (1) · Hany H El Sayed, Professor (1) · Hiren Mehta, MD (1) · Jason Akulian, MD, MPH (1) · Jed Gorden, MD (1) · Jonathan T Puchalski, MD, MEd (1) · Julio A Ramirez, MD (1) · Jun Liu, associate director (1) · L. Lacerna, MD (1) · Mark Block, MD (1)
PMID 19349389, PMID 20084586, PMID 25236367, PMID 26423784, PMID 32421353, PMID 37043201