7 completed, 1 terminated, 1 withdrawn. 4 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 4 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 4 | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Deoxyribonucleases: new trials by email Literature Review of Deoxyribonucleases trials Research Report on Deoxyribonucleases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase) Dornase Alfa - Ischemic Stroke | Phase 2 | Completed | University of Melbourne | 330 | 2022-02-18 | 2026-05-06 |
| Impact of Discontinuing Dornase Alfa in People With CF on Highly Effective CFTR Modulator Therapy-A SIMPLIFY Sub-Study Discontinuation of dornase alfa (Dnase), Continuation of dornase alfa (Dnase) - Cystic Fibrosis | Not applicable | Completed | Nicole Hamblett | 477 | 2020-08-25 | 2024-11-26 |
| Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management Intra-pleural Alteplase 16mg with Pulmozyme (DNase) 5mg - Loculated Empyema | Not applicable | Completed | National University of Malaysia | 30 | 2019-12-30 | 2021-06-07 |
| Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication VATS Decortication, Fibrinolytic Therapy - Parapneumonic Effusion, Empyema, Pleural | Not applicable | Completed | Denver Health and Hospital Authority | 10 | 2018-07-26 | 2022-01-27 |
| Fibrinolytic Therapy Versus Medical Thoracoscopy Chest thoracoscopy, Chest fibrinolytic therapy, tPA - Pleural Diseases | Phase 4 | Completed | University of Florida | 5 | 2017-09-14 | 2024-02-20 |
| Early Intrapleural TPA Instillation Versus Late early tPA and DNase - Tissue Plasminogen Activator | Phase 4 | Withdrawn | Prisma Health-Midlands | 2017-02-17 | 2025-02-21 | |
| DNase Treatment for Dry Eyes DNase, Vehicle - Dry Eye | Phase 1 / Phase 2 | Terminated | University of Illinois at Chicago | 47 | 2014-07-01 | 2020-01-18 |
| Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) TPA (Tissue Plasminogen Activator), DNase, Placebo - Pleural Empyema | Phase 3 | Completed | The Hospital for Sick Children | 97 | 2012-12-01 | 2020-04-14 |
| Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients Pulmozyme (nebulized dornase alpha), Saline - Atelectasis, Ventilation, Mechanical | Not applicable | Completed | University of Medicine and Dentistry of New Jersey | 30 | 2005-11-01 | 2010-03-30 |
Empyema, Pleural (2) · Pleural Diseases (2) · Cystic Fibrosis (1) · Dry Eye Syndromes (1) · Hemostatic Disorders (1) · Ischemic Stroke (1) · Lung Neoplasms (1) · Pleural Effusion (1) · Pneumonia (1) · Pneumothorax (1) · Pulmonary Atelectasis (1) · Pulmonary Embolism (1) · Respiratory Aspiration (1)
Denver Health and Hospital Authority (1) · National University of Malaysia (1) · Nicole Hamblett (1) · Prisma Health-Midlands (1) · The Hospital for Sick Children (1) · University of Florida (1) · University of Illinois at Chicago (1) · University of Medicine and Dentistry of New Jersey (1) · University of Melbourne (1)
United States (6) · Australia (1) · Canada (1) · Malaysia (1)
Alex Gifford, MD, FCCP (1) · Bruce CV Campbell, MBBS PhD (1) · Eyal Cohen, MD, MSc (1) · Fredric Pieracci, MD, MPH (1) · Hiren Mehta, MD (1) · Jessica N Zitter, MD, MPH (1) · Mohamed Faisal Abdul Hamid (1) · Nicole Mayer-Hamblett, PhD (1) · Rohan Mankikar, MD (1) · Sandeep Jain, MD (1)
PMID 28646887, PMID 32011642, PMID 32421353, PMID 35581627, PMID 38710463, PMID 39869712