181 completed, 89 unknown, 36 recruiting, 25 terminated. 127 Not applicable, 58 Phase 2, 35 Phase 1, 19 Phase 4, 16 Phase 3.
Follow Pleural Effusion: new trials by email Literature Review of Pleural Effusion trials Research Report on Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Iodine Starch Test Use in Pleuroperitoneal Leak Iodine tincture - Peritoneal Dialysis, Peritoneal Dialysis (PD) | Not applicable | Not yet recruiting | Nottingham University Hospitals NHS Trust | 30 | 2026-12-01 | 2026-10-26 |
| Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis) | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3000 | 2026-10-01 | 2026-10-27 | |
| Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions Cancer Ratio and Cancer Ratio Plus - Malignant Pleural Effusion, Tuberculous Pleural Effusion | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-08-17 | |
| Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope - Malignant Pleural Effusions (Mpe), Medical Thoracoscopy | Not applicable | Recruiting | National University of Malaysia | 36 | 2026-08-20 | 2026-09-11 |
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings Cirrhosis of the Liver, Ascites | Not yet recruiting | Assiut University | 120 | 2026-08-10 | 2026-06-25 | |
| Dual-function Semirigid Thoracoscopy Versus Rigid Thoracoscopy for the Diagnosis of Pleural Disease Dual-function semi-rigid thoracoscopy, Rigid thoracoscopy - Pleural Effusion Disorder | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 92 | 2026-08-01 | 2026-06-22 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage, Placebo granules plus chest tube drainage and intrapleural bevacizumab injection - Malignant Pleural Effusions (Mpe) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 308 | 2026-06-01 | 2026-07-01 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| Pleural Effusion Types in Chronic Kidney Disease Pleural Effusion, Chronic Kidney Disease | Not yet recruiting | Assiut University | 100 | 2026-05-01 | 2026-04-23 | |
| Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions Pleural Effusion, Transudative Pleural Effusion | Not yet recruiting | Assiut University | 90 | 2026-05-01 | 2026-04-13 | |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Ultrasounic Elastography-guided Pleural Biopsy Followed by As-needed Medical Thoracoscopic Pleural Biopsy Versus Immediate Medical Thoracoscopic Pleural Biopsy for the Diagnosis of Pleural Effusion Ultrasoinc elastography-guided pleural biopsy followed by as-needed medical thoracoscopic pleural biopsy, Semi-rigid thoracoscopic pleural biopsy - Pleural Effusion Disorder | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 420 | 2026-04-01 | 2026-02-19 |
| Evaluating the Use of an App in Pleural Disease: Algorithm-supported Clinical Decision Making Versus Usual Care Clinical decision-making support tool, Usual care - Pleural Diseases, Pneumothorax Spontaneous Primary | Not applicable | Enrolling by invitation | Zealand University Hospital | 828 | 2026-04-01 | 2026-06-04 |
| Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis - Pleural Infection, Pleural Adhesions | Phase 2 | Completed | Delta University for Science and Technology | 36 | 2026-03-26 | 2026-07-20 |
| DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs Thoracentesis - Congestive Heart Failure(CHF), Pleural Effusion Due to Congestive Heart Failure | Not applicable | Recruiting | Albany Medical College | 216 | 2026-02-15 | 2026-04-30 |
| Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis Pleurodesis, pleurodesis - Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 160 | 2026-02-01 | 2026-01-06 |
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Pleural Effusion, Malignant (168) · Lung Neoplasms (46) · Carcinoma, Non-Small-Cell Lung (37) · Pneumothorax (33) · Pleural Diseases (23) · Neoplasm Metastasis (19) · Neoplasms (17) · Mesothelioma, Malignant (16) · Pulmonary Atelectasis (14) · Pneumonia (13) · Ascites (12) · Myeloproliferative Disorder, Chronic, with Eosinophilia (11) · Breast Neoplasms (10) · Empyema (10)
Respiratory Tract Diseases (369) · Pleural Diseases (347) · Neoplasms by Site (195) · Respiratory Tract Neoplasms (191) · Thoracic Neoplasms (191) · Neoplasms (190) · Pleural Neoplasms (167) · Lung Diseases (105) · Pathological Conditions, Signs and Symptoms (92) · Pathologic Processes (72) · Infections (45) · Bronchial Neoplasms (39) · Carcinoma, Bronchogenic (38) · Lung Neoplasms (36)
Cisplatin (11) · Bevacizumab (8) · Carboplatin (8) · Pleurodesis (7) · Thoracentesis (7) · Paclitaxel (6) · Talc (6) · Chest Tubes (5) · Docetaxel (5) · Thoracoscopy (5) · Doxycycline (4) · Gemcitabine (4) · Povidone-Iodine (4) · Drug Therapy (3) · Saline Solution (3)
Assiut University (20) · National Cancer Institute (NCI) (8) · M.D. Anderson Cancer Center (7) · Naestved Hospital (7) · China-Japan Friendship Hospital (6) · Post Graduate Institute of Medical Education and Research, Chandigarh (6) · University of Oxford (6) · Chinese University of Hong Kong (4) · National Taiwan University Hospital (4) · National University of Malaysia (4) · The University of Hong Kong (4) · Yale University (4) · Ain Shams University (3) · Chang Gung Memorial Hospital (3) · Guy's and St Thomas' NHS Foundation Trust (3)
United States (87) · China (38) · United Kingdom (30) · Egypt (23) · Denmark (16) · France (16) · Italy (16) · Germany (14) · Canada (12) · Taiwan (12) · Brazil (10) · India (9) · Spain (9) · Hong Kong (8) · Israel (8)
Mohamed Faisal Abdul Hamid, MBBS (IIUM) (3) · Adriana C Lunardi, PhD (2) · Ales Rozman, MD (2) · David Ost, MD (2) · David SC Hui, MD (2) · Jonathan T Puchalski, MD, MEd (2) · Lonny Yarmus, DO (2) · Meng-Chih Lin, MD (2) · Mohamed AbdElmoniem (2) · Moishe Liberman, MD, PhD (2) · Patrick Wagner, MD (2) · Ricardo M Terra, MD, PhD (2) · Adam M Dr Peel (1)
PMID 11451810, PMID 15764775, PMID 26350935, PMID 12091180, PMID 12603352, PMID 14973997, PMID 15788709, PMID 15961606, PMID 16107633, PMID 16111068, PMID 16460928, PMID 16478853, PMID 16790519, PMID 16797681, PMID 16940982, PMID 17167009, PMID 17567670, PMID 17573451, PMID 17943347, PMID 18216051, PMID 18300255, PMID 18422864, PMID 18561992, PMID 18678767, PMID 18710781, PMID 18829678, PMID 19265064, PMID 19349389, PMID 19581352, PMID 19903687, PMID 20068553, PMID 20140421, PMID 20154079, PMID 20464170, PMID 20646244, PMID 20685739, PMID 20696688, PMID 20956127, PMID 21267391, PMID 21285244, PMID 21378105, PMID 21597112, PMID 21633576, PMID 22083202, PMID 22267769, PMID 23178954, PMID 23418922, PMID 23504646, PMID 23601750, PMID 23816016
U10CA031946 (3), 2009 (1), 2014 (1), I50HX002263 (1), N01CM17101 (1), P01CA066726 (1), P30AG021342 (1), P30CA006927 (1), P30CA043703 (1), P30CA068485 (1), R21CA123866 (1), R21EB016869 (1), R44CA287829 (1), U01CA076576 (1), U10CA025224 (1)