28 completed, 16 unknown, 6 recruiting, 5 not yet recruiting. 22 Not applicable, 9 Phase 3, 9 Phase 4, 5 Phase 2, 1 Phase 1.
Follow Empyema: new trials by email Literature Review of Empyema trials Research Report on Empyema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Antibiotic Course Upon Adequate Treatment of Empyema shortened antibiotic course, Standard medical treatment - Pleural Empyema | Not applicable | Not yet recruiting | University of Arizona | 50 | 2026-11-16 | 2026-10-07 |
| VATS or Intrapleural Enzymatic Therapy for Patients With Empyema. VATS group, IET - Empyema, Pleural, Pleural Infections | Phase 4 | Not yet recruiting | Amsterdam UMC | 164 | 2026-10-01 | 2026-10-21 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis - Pleural Infection, Pleural Adhesions | Phase 2 | Completed | Delta University for Science and Technology | 36 | 2026-03-26 | 2026-07-20 |
| Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel PRISM PCR panel, Conventional bacterial culture - Pleural Infection | Not yet recruiting | Chinese University of Hong Kong | 800 | 2026-01-01 | 2025-07-22 | |
| Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily - Pleural Infection Bacterial, Pleural Infections | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 270 | 2025-09-11 | 2026-09-29 |
| Fungal Empyema Thoracis pleural lavage followed by surgery, Decortication, Conservative Arm - Pyothorax, Fungal Infection Lungs | Not applicable | Recruiting | University of Health Sciences Lahore | 50 | 2025-07-01 | 2026-01-13 |
| Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas Saline Flush - Empyema, Pleural, Pleural Infection | Not applicable | Recruiting | Vanderbilt University Medical Center | 96 | 2024-06-21 | 2026-02-20 |
| Complicated Pneumonia (CP) in Children in South-East Europe Pneumonia, Necrotizing, Lung Abscess | Recruiting | Aleksandar Sovtic | 300 | 2024-05-27 | 2024-10-26 | |
| Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema Levofloxacin + clindamycin, Levofloxacin + cefipime - Empyema, Pleural | Not applicable | Completed | Fayoum University | 80 | 2024-05-01 | 2026-06-05 |
| Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema video assisted thoracoscopy (VATS), open thoracotomy - Thoracic Empyema | Not applicable | Unknown | Assiut University | 73 | 2024-04-01 | 2024-05-23 |
| Is Intercostal Tube Enough in Management of Empyema intercostal tube - Empyema | Not applicable | Not yet recruiting | Assiut University | 100 | 2024-03-01 | 2024-01-31 |
| Medical Thoracoscopy in Treatment Outcomes of Empyema Management Thoracoscopy procedure, Chest tube thoracostomy - Empyema | Not applicable | Unknown | Hend Mohamed Sayed Mohamed | 100 | 2023-12-24 | 2023-11-15 |
| Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema Thoracis Uniportal VATS, Multi-portal VATS - Empyema, Pleural, Thoracic Empyema | Not applicable | Completed | University of Health Sciences Lahore | 160 | 2023-04-01 | 2025-08-22 |
| VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema VATS group, Drain and intrapleural therapy group - Pleural Empyema | Not applicable | Recruiting | Thomas Decker Christensen | 184 | 2022-10-30 | 2025-10-03 |
| Trial of Antiseptic Irrigation for Pleural Infection Povidone-iodine solution, Normal saline - Empyema, Pleural | Phase 2 | Completed | Alexandria University | 22 | 2022-09-19 | 2026-06-30 |
| Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients. MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL) - Thoracic Diseases, Thoracic Neoplasms | Not applicable | Unknown | Aga Khan University | 84 | 2022-06-15 | 2023-08-14 |
| The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront Decortication - Pleural Empyema, Tuberculosis (TB) | Completed | University of Health Sciences Lahore | 350 | 2022-01-01 | 2025-09-15 | |
| Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Diclofenac, Placebo - Pleural Neoplasms, Aspiration, Respiratory | Phase 4 | Unknown | Assiut University | 100 | 2021-11-01 | 2021-11-16 |
| VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema Video assisted thorascopic decortication, Interventional radiology guided chest tube insertion with MIST2 trial fibrinolytics - Empyema, Pleural | Not applicable | Unknown | Dr. Wiley Chung | 70 | 2021-08-24 | 2023-11-18 |
Showing 20 of 58. Sign in to see all of them.
Empyema, Pleural (33) · Pleural Effusion (12) · Hemothorax (5) · Pleural Diseases (5) · Pneumothorax (5) · Pneumonia (4) · Lung Neoplasms (3) · Pleural Effusion, Malignant (3) · Chylothorax (2) · Community-Acquired Pneumonia (2) · Infections (2) · Inflammation (2) · Neoplasms (2) · Pleural Neoplasms (2)
Pathologic Processes (58) · Pathological Conditions, Signs and Symptoms (58) · Suppuration (58) · Infections (56) · Inflammation (56) · Respiratory Tract Diseases (47) · Pleural Diseases (39) · Respiratory Tract Infections (38) · Lung Diseases (10) · Neoplasms by Site (6) · Hemorrhage (5) · Neoplasms (5) · Respiratory Tract Neoplasms (5) · Thoracic Neoplasms (5)
Tissue Plasminogen Activator (5) · Thoracic Surgery, Video-Assisted (4) · Cerebral Decortication (3) · Saline Solution (3) · dornase alfa (3) · Chest Tubes (2) · Clindamycin (2) · Deoxyribonucleases (2) · Urokinase-Type Plasminogen Activator (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Anesthesia, General (1) · Cefazolin (1) · Cone-Beam Computed Tomography (1) · Dexamethasone (1) · Diclofenac (1)
Assiut University (4) · University of Health Sciences Lahore (3) · Beijing Children's Hospital (2) · Centre Hospitalier Universitaire, Amiens (2) · Children's Mercy Hospital Kansas City (2) · Chinese University of Hong Kong (2) · Aga Khan University (1) · Aleksandar Sovtic (1) · Alexandria University (1) · Amsterdam UMC (1) · Azienda Ospedaliera di Padova (1) · BERBERI ANTOINE (1) · Dartmouth-Hitchcock Medical Center (1) · Delta University for Science and Technology (1) · Denver Health and Hospital Authority (1)
United States (15) · Egypt (6) · Pakistan (4) · United Kingdom (4) · Italy (3) · Spain (3) · Canada (2) · China (2) · Denmark (2) · France (2) · Hong Kong (2) · India (2) · Belgium (1) · Brazil (1) · Greece (1)
Shawn D St. Peter, MD (2) · Abdelrahman Ahmed Mohamed, Teaching assistant (1) · Adam Jaffe, Dr (1) · Ahmed F Koraitim, MD (1) · Babu Naidu, MBBS (1) · Bradford Wood, M.D. (1) · Bradley W Thomas, MD (1) · Christian B Laursen, MD, PhD (1) · David Shitrit, MD (1) · Erin Williams, MD (1) · Eyal Cohen, MD, MSc (1) · Fayez Kheir, MD, MSc (1) · Federico Raveglia, MD (1)
PMID 18492739, PMID 20304453, PMID 20736395, PMID 22327984, PMID 24375295, PMID 26409714, PMID 26423784, PMID 26835359, PMID 27461586, PMID 28363363, PMID 28646887, PMID 30621729, PMID 31662765, PMID 32011642, PMID 33642100, PMID 35264347, PMID 37043201, PMID 38710463, PMID 39700058, PMID 41785244
2009 (1)