223 completed, 86 unknown, 61 recruiting, 61 terminated. 209 Phase 2, 150 Phase 1, 62 Not applicable, 25 Phase 3, 11 Phase 4.
Follow Pleural Neoplasms: new trials by email Literature Review of Pleural Neoplasms trials Research Report on Pleural Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 3 Trial in Advanced Epithelioid Mesothelioma VT3989, gemcitabine, Vinorelbine - Pleural Mesothelioma, Mesothelioma | Phase 3 | Not yet recruiting | Vivace Therapeutics, Inc | 350 | 2026-12-01 | 2026-09-17 |
| Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural Mesothelioma Ivonescimab Combined With Chemotherapy - Malignant Pleural Mesothelioma, Advanced | Phase 1 / Phase 2 | Not yet recruiting | Ruijin Hospital | 78 | 2026-11-01 | 2026-10-21 |
| Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis) | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3000 | 2026-10-01 | 2026-10-20 | |
| Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions Cancer Ratio and Cancer Ratio Plus - Malignant Pleural Effusion, Tuberculous Pleural Effusion | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-08-17 | |
| Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope - Malignant Pleural Effusions (Mpe), Medical Thoracoscopy | Not applicable | Recruiting | National University of Malaysia | 36 | 2026-08-20 | 2026-09-11 |
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors TLN-499, Venetoclax - Small Cell Lung Cancer ( SCLC ), Neuroendocrine Cancer | Phase 1 | Recruiting | Treeline Biosciences, Inc. | 120 | 2026-08-05 | 2026-10-01 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| Evaluation of Skin Tests in Biotherapy Allergies Drug skin tests (investigating hypersensitivity to a biotherapy) - Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms | Not applicable | Recruiting | University Hospital, Angers | 70 | 2026-06-17 | 2026-06-18 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage, Placebo granules plus chest tube drainage and intrapleural bevacizumab injection - Malignant Pleural Effusions (Mpe) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 308 | 2026-06-01 | 2026-07-01 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Trial Assessing Fianlimab Plus Cemiplimab Plus Chemotherapy or Cemiplimab Plus Chemotherapy in Patients With Pleural Mesothelioma Cemiplimab, Fianlimab, Pemetrexed (Alimta) - Pleural Mesotheliomas | Phase 2 | Recruiting | Intergroupe Francophone de Cancerologie Thoracique | 126 | 2026-04-02 | 2026-08-11 |
| Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology Blood and Tissue Collection - Small Cell Lung Cancer, Head and Neck Cancer | Not yet recruiting | University of Kansas Medical Center | 110 | 2026-04-01 | 2026-04-24 | |
| Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma alrizomadlin - Mesothelioma, Malignant Mesothelioma (MM) | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2026-03-16 | 2026-03-17 | |
| A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors IDE892, IDE397 - NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC) | Phase 1 | Recruiting | IDEAYA Biosciences | 260 | 2026-03-04 | 2026-09-28 |
| Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide - Malignant Pleural Mesotheliomas | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-04-06 |
| Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis Pleurodesis, pleurodesis - Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 160 | 2026-02-01 | 2026-01-06 |
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Mesothelioma, Malignant (329) · Pleural Effusion, Malignant (167) · Carcinoma, Non-Small-Cell Lung (90) · Mesothelioma (67) · Lung Neoplasms (60) · Neoplasms (38) · Pleural Effusion (34) · Neoplasm Metastasis (30) · Ovarian Neoplasms (28) · Breast Neoplasms (27) · Esophageal Neoplasms (27) · Pancreatic Neoplasms (27) · Small Cell Lung Carcinoma (26) · Solitary Fibrous Tumor, Pleural (26) · Carcinoma, Renal Cell (24)
Respiratory Tract Neoplasms (498) · Neoplasms by Site (497) · Thoracic Neoplasms (496) · Respiratory Tract Diseases (495) · Neoplasms (461) · Lung Diseases (381) · Neoplasms by Histologic Type (348) · Neoplasms, Glandular and Epithelial (348) · Adenoma (338) · Neoplasms, Mesothelial (336) · Lung Neoplasms (323) · Mesothelioma (270) · Pleural Diseases (174) · Pleural Effusion (139)
Cisplatin (67) · Pemetrexed (48) · Carboplatin (23) · Gemcitabine (18) · pembrolizumab (18) · Nivolumab (17) · Drug Therapy (14) · Cyclophosphamide (13) · Bevacizumab (11) · Radiotherapy (10) · Paclitaxel (8) · atezolizumab (8) · Doxorubicin (7) · Ipilimumab (7) · Platinum (7)
National Cancer Institute (NCI) (38) · M.D. Anderson Cancer Center (15) · Memorial Sloan Kettering Cancer Center (15) · Alliance for Clinical Trials in Oncology (9) · Ain Shams University (7) · Assiut University (7) · European Organisation for Research and Treatment of Cancer - EORTC (7) · Naestved Hospital (6) · University of Chicago (6) · Abramson Cancer Center at Penn Medicine (5) · Mayo Clinic (5) · Swiss Cancer Institute (5) · University Health Network, Toronto (5) · Eli Lilly and Company (4) · H. Lee Moffitt Cancer Center and Research Institute (4)
United States (215) · United Kingdom (51) · China (49) · Italy (46) · France (32) · Canada (26) · Netherlands (23) · Australia (22) · Belgium (21) · Germany (18) · Spain (18) · Switzerland (17) · Egypt (16) · Denmark (14) · Poland (14)
David S Schrump, M.D. (8) · Armando Santoro, MD (4) · Hedy Kindler (4) · Anne S Tsao (3) · Antonio Lambiase, MD (3) · David J. Sugarbaker, MD (3) · Dennis Wigle, MD, PhD (3) · Michael Offin, MD (3) · Andreas Rimner, MD (2) · Anne S. Tsao, MD (2) · Arkadiusz Dudek, MD (2) · Charles L. Wiseman, MD, FACP (2) · David Ost, MD (2)
PMID 15764775, PMID 31576173, PMID 33358660, PMID 34499875, PMID 37279993, PMID 10500494, PMID 11165136, PMID 11451810, PMID 11487589, PMID 12565988, PMID 14973997, PMID 15084390, PMID 16107633, PMID 16111068, PMID 16192580, PMID 16446322, PMID 16460928, PMID 16478853, PMID 16554548, PMID 16790519, PMID 16797681, PMID 16940982, PMID 17295916, PMID 17395581, PMID 17429100, PMID 17567670, PMID 17573451, PMID 18006112, PMID 18089874, PMID 18204189, PMID 18224661, PMID 18300255, PMID 18486741, PMID 18561992, PMID 18678767, PMID 18710781, PMID 18797818, PMID 19158121, PMID 19349389, PMID 19360120, PMID 19451433, PMID 19556318, PMID 19564349, PMID 19652065, PMID 19671873, PMID 20068553, PMID 20167848, PMID 20400682, PMID 20406925, PMID 20525721
U10CA031946 (11), 2023 (5), U10CA032102 (5), 2017 (3), P30CA014599 (3), P30CA043703 (3), 2008 (2), 2009 (2), 2014 (2), N01CM17102 (2), P01CA066726 (2), P30CA006927 (2), P30CA016672 (2), P30CA022453 (2), U10CA021115 (2)