67 completed, 44 unknown, 18 terminated, 17 recruiting. 42 Phase 2, 38 Not applicable, 33 Phase 1, 10 Phase 3, 9 Phase 4.
Follow Pleural Effusion, Malignant: new trials by email Literature Review of Pleural Effusion, Malignant trials Research Report on Pleural Effusion, Malignant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis) | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3000 | 2026-10-01 | 2026-10-27 | |
| Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions Cancer Ratio and Cancer Ratio Plus - Malignant Pleural Effusion, Tuberculous Pleural Effusion | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-08-17 | |
| Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope - Malignant Pleural Effusions (Mpe), Medical Thoracoscopy | Not applicable | Recruiting | National University of Malaysia | 36 | 2026-08-20 | 2026-09-11 |
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage, Placebo granules plus chest tube drainage and intrapleural bevacizumab injection - Malignant Pleural Effusions (Mpe) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 308 | 2026-06-01 | 2026-07-01 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis Pleurodesis, pleurodesis - Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 160 | 2026-02-01 | 2026-01-06 |
| Pleurodesis in Small-bore Chest Tube 14 Fr chest tube, 12 Fr chest tube, 8 Fr chest tube - Pleural Effusion, Malignant | Not applicable | Not yet recruiting | The University of Hong Kong | 60 | 2026-02-01 | 2025-12-24 |
| Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion intercostal tube drainage, big tail catheter drainage, ultrasound-guided aspiration - Malignant Pleural Effusion | Not applicable | Not yet recruiting | Assiut University | 66 | 2025-06-01 | 2025-05-09 |
| Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound side to side and front to back rotation 30 minutes each - Effect of Patient Rotation on Pleurodesis Success and Patient Comfort, Malignant Pleural Effusion | Not applicable | Recruiting | Ain Shams University | 30 | 2025-05-01 | 2025-08-29 |
| ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG Air Entrainment - intentional introduction of the atmospheric air into the pleural space. - Non-expandable Lung, Trapped Lung | Not applicable | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 41 | 2025-04-14 | 2025-05-07 |
| The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion Intercostal chest tube, Pleurodesis - Malignant Pleural Effusions (Mpe) | Early Phase 1 | Not yet recruiting | Assiut University | 20 | 2024-12-30 | 2024-12-19 |
| A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197, Tube thoracostomy drainage - Malignant Pleural Effusions (Mpe) | Phase 1 | Recruiting | Jemincare | 30 | 2024-12-28 | 2025-04-04 |
| Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion Group 1 (mechanical pleurodesis), Group 2 chemical pleurodesis by bleomycin) - Malignant Pleural Effusion | Not applicable | Not yet recruiting | Assiut University | 70 | 2024-12-10 | 2024-11-15 |
| Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs Stage III Breast Cancer, Stage IV Breast Cancer | Withdrawn | Travera Inc | 2024-11-01 | 2024-11-25 | ||
| Cytological Examination of Malignant Pleural Effusion in Breast Cancer Thoracentesis - Malignant Pleural Effusion | Completed | Mansoura University Hospital | 50 | 2024-10-19 | 2025-05-29 |
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Carcinoma, Non-Small-Cell Lung (32) · Lung Neoplasms (29) · Pleural Effusion (28) · Neoplasm Metastasis (17) · Mesothelioma, Malignant (12) · Myeloproliferative Disorder, Chronic, with Eosinophilia (11) · Breast Neoplasms (10) · Neoplasms (10) · Pleural Diseases (7) · Adenocarcinoma of Lung (6) · Esophageal Neoplasms (6) · Small Cell Lung Carcinoma (6) · Anus Neoplasms (5) · Carcinoma, Hepatocellular (5)
Neoplasms by Site (166) · Respiratory Tract Diseases (166) · Respiratory Tract Neoplasms (166) · Thoracic Neoplasms (166) · Pleural Neoplasms (162) · Pleural Diseases (160) · Neoplasms (157) · Pleural Effusion (139) · Lung Diseases (58) · Bronchial Neoplasms (34) · Carcinoma, Bronchogenic (33) · Lung Neoplasms (30) · Pathological Conditions, Signs and Symptoms (29) · Pathologic Processes (27) · Neoplasms by Histologic Type (26)
Cisplatin (9) · Bevacizumab (8) · Carboplatin (8) · Pleurodesis (7) · Paclitaxel (6) · Talc (6) · Docetaxel (5) · Doxycycline (4) · Povidone-Iodine (4) · Chest Tubes (3) · Drug Therapy (3) · Gemcitabine (3) · Taxes (3) · Thoracoscopy (3) · Bortezomib (2)
National Cancer Institute (NCI) (8) · Assiut University (6) · Naestved Hospital (6) · M.D. Anderson Cancer Center (5) · The University of Hong Kong (4) · H. Lee Moffitt Cancer Center and Research Institute (3) · Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Abramson Cancer Center at Penn Medicine (2) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (2) · Alliance for Clinical Trials in Oncology (2) · C. R. Bard (2) · Duke University (2) · Grupo de Pesquisa em Pleura e Oncologia Toracica (2) · Guy's and St Thomas' NHS Foundation Trust (2) · Jemincare (2)
United States (50) · China (30) · United Kingdom (16) · Canada (7) · Denmark (7) · Egypt (7) · Brazil (5) · France (4) · Hong Kong (4) · India (4) · South Korea (4) · Australia (3) · Germany (3) · Greece (3) · Ireland (3)
David Ost, MD (2) · Patrick Wagner, MD (2) · Ricardo M Terra, MD, PhD (2) · Ahmed F Koraitim, MD (1) · Alberto Chiappori, MD (1) · Alexander Chen, M.D. (1) · Angela Davies (1) · Anthony W. Tolcher, MD (1) · Apichat Tantraworasin (1) · Balazs Halmos, MD (1) · Ben Creelan, M.D. (1) · Bo Huang, Ph.D (1)
PMID 15764775, PMID 11451810, PMID 14973997, PMID 16107633, PMID 16111068, PMID 16460928, PMID 16478853, PMID 16790519, PMID 16797681, PMID 16940982, PMID 17567670, PMID 17573451, PMID 18300255, PMID 18561992, PMID 18678767, PMID 18710781, PMID 19349389, PMID 20068553, PMID 20696688, PMID 21267391, PMID 22083202, PMID 23178954, PMID 23925664, PMID 24480929, PMID 24942631, PMID 25377015, PMID 25798278, PMID 25874452, PMID 26720026, PMID 27007334, PMID 28344925, PMID 29186319, PMID 29550074, PMID 29862030, PMID 30243566, PMID 30272503, PMID 31374208, PMID 31525813, PMID 31804680, PMID 33222091, PMID 33538338, PMID 35080187, PMID 35363591, PMID 36402752, PMID 37428348, PMID 38243259, PMID 40628689, PMID 42448681, PMID 42669653, PMID 591413
U10CA031946 (3), 2014 (1), N01CM17101 (1), P30CA006927 (1), P30CA043703 (1), R21CA123866 (1), U01CA076576 (1), U10CA025224 (1), U10CA076001 (1), U10CA180821 (1)