287 completed, 149 unknown, 70 recruiting, 38 terminated. 232 Not applicable, 73 Phase 2, 41 Phase 1, 35 Phase 3, 28 Phase 4.
Follow Pleural Diseases: new trials by email Literature Review of Pleural Diseases trials Research Report on Pleural Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Iodine Starch Test Use in Pleuroperitoneal Leak Iodine tincture - Peritoneal Dialysis, Peritoneal Dialysis (PD) | Not applicable | Not yet recruiting | Nottingham University Hospitals NHS Trust | 30 | 2026-12-01 | 2026-10-26 |
| Evaluating Antibiotic Course Upon Adequate Treatment of Empyema shortened antibiotic course, Standard medical treatment - Pleural Empyema | Not applicable | Not yet recruiting | University of Arizona | 50 | 2026-11-16 | 2026-10-07 |
| VATS or Intrapleural Enzymatic Therapy for Patients With Empyema. VATS group, IET - Empyema, Pleural, Pleural Infections | Phase 4 | Recruiting | Amsterdam UMC | 164 | 2026-10-01 | 2026-10-26 |
| Clinical Value of Routine Chest Radiography and Point-of-Care Lung Ultrasound Following Ambulatory Thoracic Sympathectomy Pneumothorax Iatrogenic Postprocedural | Not yet recruiting | Clinica Alemana de Santiago | 200 | 2026-10-01 | 2026-10-02 | |
| The Impact of Artificial Intelligence-Assisted X-ray Interpretation on Radiologists' Diagnostic Performance Pneumothorax, Intestinal Obstruction | Not yet recruiting | The Third Affiliated Hospital of Southern Medical University | 500 | 2026-10-01 | 2026-10-15 | |
| Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis) | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3000 | 2026-10-01 | 2026-10-27 | |
| Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions Cancer Ratio and Cancer Ratio Plus - Malignant Pleural Effusion, Tuberculous Pleural Effusion | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-08-17 | |
| Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope - Malignant Pleural Effusions (Mpe), Medical Thoracoscopy | Not applicable | Recruiting | National University of Malaysia | 36 | 2026-08-20 | 2026-09-11 |
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings Cirrhosis of the Liver, Ascites | Not yet recruiting | Assiut University | 120 | 2026-08-10 | 2026-06-25 | |
| Dual-function Semirigid Thoracoscopy Versus Rigid Thoracoscopy for the Diagnosis of Pleural Disease Dual-function semi-rigid thoracoscopy, Rigid thoracoscopy - Pleural Effusion Disorder | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 92 | 2026-08-01 | 2026-06-22 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage, Placebo granules plus chest tube drainage and intrapleural bevacizumab injection - Malignant Pleural Effusions (Mpe) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 308 | 2026-06-01 | 2026-07-01 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| Pleural Effusion Types in Chronic Kidney Disease Pleural Effusion, Chronic Kidney Disease | Not yet recruiting | Assiut University | 100 | 2026-05-01 | 2026-04-23 | |
| Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions Pleural Effusion, Transudative Pleural Effusion | Not yet recruiting | Assiut University | 90 | 2026-05-01 | 2026-04-13 | |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| Suction vs Underwater Seal for HemoPneumoThoraX Trial Suction, Water Seal - Hemothorax; Traumatic, Hemopneumothorax; Traumatic | Not applicable | Recruiting | Vanderbilt University Medical Center | 150 | 2026-04-14 | 2026-06-02 |
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Pleural Effusion (230) · Pneumothorax (174) · Pleural Effusion, Malignant (167) · Lung Neoplasms (63) · Carcinoma, Non-Small-Cell Lung (40) · Empyema, Pleural (33) · Hemothorax (24) · Pulmonary Atelectasis (22) · Empyema (21) · Neoplasms (21) · Pneumonia (21) · Mesothelioma, Malignant (19) · Neoplasm Metastasis (19) · Pleural Neoplasms (17)
Respiratory Tract Diseases (600) · Neoplasms by Site (224) · Neoplasms (219) · Respiratory Tract Neoplasms (217) · Thoracic Neoplasms (216) · Pathological Conditions, Signs and Symptoms (175) · Pleural Neoplasms (169) · Lung Diseases (152) · Pathologic Processes (148) · Pleural Effusion (139) · Infections (90) · Respiratory Tract Infections (75) · Neoplasms by Histologic Type (46) · Suppuration (45)
Cisplatin (12) · Thoracic Surgery, Video-Assisted (10) · Chest Tubes (9) · Bevacizumab (8) · Carboplatin (8) · Thoracentesis (8) · Thoracoscopy (8) · Pleurodesis (7) · Saline Solution (7) · Tissue Plasminogen Activator (7) · Paclitaxel (6) · Talc (6) · Docetaxel (5) · Doxycycline (5) · Deoxyribonucleases (4)
Assiut University (28) · National Taiwan University Hospital (15) · Chinese University of Hong Kong (9) · National Cancer Institute (NCI) (9) · M.D. Anderson Cancer Center (8) · China-Japan Friendship Hospital (7) · Naestved Hospital (7) · Post Graduate Institute of Medical Education and Research, Chandigarh (6) · University of Oxford (6) · Chang Gung Memorial Hospital (5) · Eskisehir Osmangazi University (5) · Ain Shams University (4) · Icahn School of Medicine at Mount Sinai (4) · National University of Malaysia (4) · Oxford University Hospitals NHS Trust (4)
United States (139) · China (50) · Egypt (34) · United Kingdom (34) · France (32) · Italy (30) · Taiwan (27) · Canada (23) · Denmark (23) · Germany (18) · Hong Kong (13) · Turkey (Türkiye) (13) · Israel (12) · Brazil (11) · India (11)
Yung-Chie Lee, MD, PhD (6) · David SC Hui, MD (3) · Jin-Shing Chen, MD, PhD (3) · Mohamed Faisal Abdul Hamid, MBBS (IIUM) (3) · Udit Chaddha, MBBS (3) · Adriana C Lunardi, PhD (2) · Ales Rozman, MD (2) · Chi-Li Chung, MD, PhD (2) · David Ost, MD (2) · Deborah L O'Connor, PhD RD (2) · Devanand Anantham, MRCP (2) · Elena Bignami, MD (2) · Idit Matot, MD (2) · Jacobo Moreno Garijo, MD (2) · Jennifer Russell, MD (2)
PMID 24375295, PMID 26350935, PMID 11451810, PMID 15764775, PMID 23188235, PMID 23418922, PMID 32421353, PMID 10027442, PMID 10727592, PMID 10834680, PMID 10899243, PMID 10963540, PMID 11171742, PMID 11265032, PMID 11991872, PMID 12091180, PMID 12355007, PMID 12603352, PMID 14973997, PMID 15082295, PMID 15345974, PMID 15454805, PMID 15753638, PMID 15788709, PMID 15795288, PMID 15862493, PMID 15961606, PMID 16107633, PMID 16111068, PMID 16135163, PMID 16302942, PMID 16307931, PMID 16460928, PMID 16478853, PMID 16508485, PMID 16778275, PMID 16790519, PMID 16797681, PMID 16940982, PMID 17161082, PMID 17167009, PMID 17253510, PMID 17414339, PMID 17567670, PMID 17573451, PMID 17650692, PMID 17925411, PMID 17943347, PMID 18053373, PMID 18204189
U10CA031946 (3), 2009 (1), 2014 (1), I50HX002263 (1), N01CM17101 (1), P01CA066726 (1), P30AG021342 (1), P30CA006927 (1), P30CA033572 (1), P30CA043703 (1), P30CA068485 (1), R21CA123866 (1), R21EB016869 (1), U01CA076576 (1), U10CA025224 (1)