15 completed, 9 unknown, 5 recruiting, 3 not yet recruiting. 13 Not applicable, 7 Phase 4, 4 Phase 3, 3 Phase 2.
Follow Empyema, Pleural: new trials by email Literature Review of Empyema, Pleural trials Research Report on Empyema, Pleural
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Antibiotic Course Upon Adequate Treatment of Empyema shortened antibiotic course, Standard medical treatment - Pleural Empyema | Not applicable | Not yet recruiting | University of Arizona | 50 | 2026-11-16 | 2026-10-07 |
| VATS or Intrapleural Enzymatic Therapy for Patients With Empyema. VATS group, IET - Empyema, Pleural, Pleural Infections | Phase 4 | Not yet recruiting | Amsterdam UMC | 164 | 2026-10-01 | 2026-10-21 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis - Pleural Infection, Pleural Adhesions | Phase 2 | Completed | Delta University for Science and Technology | 36 | 2026-03-26 | 2026-07-20 |
| Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily - Pleural Infection Bacterial, Pleural Infections | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 270 | 2025-09-11 | 2026-09-29 |
| Fungal Empyema Thoracis pleural lavage followed by surgery, Decortication, Conservative Arm - Pyothorax, Fungal Infection Lungs | Not applicable | Recruiting | University of Health Sciences Lahore | 50 | 2025-07-01 | 2026-01-13 |
| Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas Saline Flush - Empyema, Pleural, Pleural Infection | Not applicable | Recruiting | Vanderbilt University Medical Center | 96 | 2024-06-21 | 2026-02-20 |
| Complicated Pneumonia (CP) in Children in South-East Europe Pneumonia, Necrotizing, Lung Abscess | Recruiting | Aleksandar Sovtic | 300 | 2024-05-27 | 2024-10-26 | |
| Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema Levofloxacin + clindamycin, Levofloxacin + cefipime - Empyema, Pleural | Not applicable | Completed | Fayoum University | 80 | 2024-05-01 | 2026-06-05 |
| Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema video assisted thoracoscopy (VATS), open thoracotomy - Thoracic Empyema | Not applicable | Unknown | Assiut University | 73 | 2024-04-01 | 2024-05-23 |
| Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema Thoracis Uniportal VATS, Multi-portal VATS - Empyema, Pleural, Thoracic Empyema | Not applicable | Completed | University of Health Sciences Lahore | 160 | 2023-04-01 | 2025-08-22 |
| VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema VATS group, Drain and intrapleural therapy group - Pleural Empyema | Not applicable | Recruiting | Thomas Decker Christensen | 184 | 2022-10-30 | 2025-10-03 |
| Trial of Antiseptic Irrigation for Pleural Infection Povidone-iodine solution, Normal saline - Empyema, Pleural | Phase 2 | Completed | Alexandria University | 22 | 2022-09-19 | 2026-06-30 |
| Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients. MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL) - Thoracic Diseases, Thoracic Neoplasms | Not applicable | Unknown | Aga Khan University | 84 | 2022-06-15 | 2023-08-14 |
| The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront Decortication - Pleural Empyema, Tuberculosis (TB) | Completed | University of Health Sciences Lahore | 350 | 2022-01-01 | 2025-09-15 | |
| Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Diclofenac, Placebo - Pleural Neoplasms, Aspiration, Respiratory | Phase 4 | Unknown | Assiut University | 100 | 2021-11-01 | 2021-11-16 |
| VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema Video assisted thorascopic decortication, Interventional radiology guided chest tube insertion with MIST2 trial fibrinolytics - Empyema, Pleural | Not applicable | Unknown | Dr. Wiley Chung | 70 | 2021-08-24 | 2023-11-18 |
| The Oxford Pleural Infection Endotyping Study Pleural Infection, Pleural Diseases | Completed | University of Oxford | 80 | 2021-06-20 | 2024-07-22 | |
| Uniportal VATS Versus Chest Tube for Early Empyema Uniportal VATS, Tube thoracostomy - Empyema, Pleural | Not applicable | Completed | Minia University | 70 | 2021-03-01 | 2024-03-25 |
| The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications Lung parenchyma resection, Empyemectomy - Surgical Complication, COVID-19 | Completed | University of Milano Bicocca | 83 | 2020-03-01 | 2023-05-30 |
Showing 20 of 33. Sign in to see all of them.
Empyema (10) · Pleural Effusion (7) · Pleural Diseases (4) · Pneumothorax (4) · Hemothorax (2) · Inflammation (2) · Lung Neoplasms (2) · Pleural Neoplasms (2) · Pneumonia (2) · Respiratory Aspiration (2) · Thoracic Diseases (2) · Abscess (1) · COVID-19 (1) · Chylothorax (1)
Infections (33) · Pathologic Processes (33) · Pathological Conditions, Signs and Symptoms (33) · Respiratory Tract Diseases (33) · Respiratory Tract Infections (33) · Suppuration (33) · Inflammation (31) · Pleural Diseases (29) · Empyema (23) · Lung Diseases (6) · Neoplasms (4) · Neoplasms by Site (4) · Respiratory Tract Neoplasms (3) · Thoracic Neoplasms (3) · Adenoma (2)
Cerebral Decortication (3) · Saline Solution (3) · dornase alfa (3) · Deoxyribonucleases (2) · Tissue Plasminogen Activator (2) · Anesthesia, General (1) · Chest Tubes (1) · Clindamycin (1) · Diclofenac (1) · Drainage (1) · Levofloxacin (1) · Mortality (1) · One-Lung Ventilation (1) · Quality of Life (1) · Surgical Procedures, Operative (1)
University of Health Sciences Lahore (3) · Assiut University (2) · Aga Khan University (1) · Aleksandar Sovtic (1) · Alexandria University (1) · Amsterdam UMC (1) · Azienda Ospedaliera di Padova (1) · Beijing Children's Hospital (1) · Centre Hospitalier Universitaire, Amiens (1) · Chinese University of Hong Kong (1) · Dartmouth-Hitchcock Medical Center (1) · Delta University for Science and Technology (1) · Denver Health and Hospital Authority (1) · Dr. Wiley Chung (1) · Fayoum University (1)
United States (7) · Egypt (6) · Pakistan (4) · Italy (3) · United Kingdom (3) · Canada (2) · Belgium (1) · Brazil (1) · Denmark (1) · France (1) · Greece (1) · Hong Kong (1) · India (1) · Nigeria (1) · Serbia (1)
Abdelrahman Ahmed Mohamed, Teaching assistant (1) · Ahmed F Koraitim, MD (1) · Babu Naidu, MBBS (1) · Christian B Laursen, MD, PhD (1) · Erin Williams, MD (1) · Eyal Cohen, MD, MSc (1) · Federico Raveglia, MD (1) · Fredric Pieracci, MD, MPH (1) · Giorgio Stefanutti, MD (1) · Hany H El Sayed, Professor (1) · Jason Akulian, MD, MPH (1) · Jed Gorden, MD (1) · Jennifer D Duke, MD (1) · Ka Pang Chan, MBChB (1) · Lateef A Baiyewu, MD,FWACS (1)
PMID 20304453, PMID 20736395, PMID 26423784, PMID 26835359, PMID 28646887, PMID 30621729, PMID 32011642, PMID 33642100, PMID 35264347, PMID 37043201, PMID 38710463, PMID 41785244