25 completed, 12 unknown, 6 terminated, 6 withdrawn. 16 Not applicable, 9 Phase 4, 8 Phase 2, 6 Phase 3, 4 Phase 1.
Follow Peripheral Arterial Occlusive Disease: new trials by email Literature Review of Peripheral Arterial Occlusive Disease trials Research Report on Peripheral Arterial Occlusive Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia APAC - dose level 0.50 mg/kg,, Unfractionated heparin (UFH), APAC dose level 1: 0.25 mg/kg, - Peripheral Arterial Occlusive Disease, Chronic Limb-Threatening Ischemia | Phase 2 | Recruiting | Aplagon Oy | 42 | 2026-01-29 | 2026-04-09 |
| Wearable Devices Assist in the Detection, Screening, and Management of Major Diseases in Middle-aged and Elderly Populations Smartwatch + GP, GP only - Coronary Stenosis, Cerebral Arterial Diseases | Not applicable | Not yet recruiting | Tongji Hospital | 800 | 2025-06-01 | 2025-05-20 |
| VITUS Post-Market Registry Percutaneous Transluminal Angioplasty with a paclitaxel drug-coated balloon - Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease | Active not recruiting | OrbusNeich | 283 | 2025-05-22 | 2026-08-13 | |
| Medium-term Results of Lower Limb Arterial Bypass Graft dysfunction will be assessed through clinical examination and imaging follow-up to detect occlusion, pseudoaneurysm, aneurysm rupture, infection, or major amputation of the treated limb. - Peripheral Arterial Occlusive Disease, Critical Limb Ischemia | Completed | Hospices Civils de Lyon | 57 | 2025-01-01 | 2025-07-30 | |
| Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease Vumerity, Placebo - Peripheral Artery Disease, Peripheral Vascular Diseases | Early Phase 1 | Recruiting | University of Nebraska | 20 | 2024-11-14 | 2026-06-24 |
| Safety, Tolerability, and Biodistribution of [89Zr]Zr-DFO-APAC in Subjects With PAOD/CLI and Healthy Volunteers (Acronyms: 89Zr = Zirconium-89, DFO = Desferrioxamine, APAC = AntiPlatelet AntiCoagulant, PET/CT = Positron Emission Tomography/Computed Tomography) [89Zr]Zr-DFO-APAC, PET/CT scan - Peripheral Arterial Occlusive Disease, Critical Limb Ischemia | Early Phase 1 | Unknown | Aplagon Oy | 10 | 2024-02-01 | 2025-01-30 |
| RESPONSE-2-PAD to Reduce Sedentary Time in Peripheral Arterial Disease Patients RESPONSE-2-PAD - Peripheral Arterial Disease, Sedentary Behavior | Not applicable | Unknown | National Institute for Prevention and Cardiovascular Health, Ireland | 50 | 2023-09-29 | 2024-04-09 |
| The SIR-POBA Bypass Trial Balloon Angioplasty - Peripheral Arterial Occlusive Disease, Bypass Complication | Not applicable | Withdrawn | Paracelsus Medical University | 2023-09-20 | 2025-06-29 | |
| FRAMED Infrainguinal Venous Bypass Versus Conventional Autologous Bypass Trial FRAMED Infrainguinal Venous Bypass, Conventional Autologous Bypass - Peripheral Arterial Occlusive Disease, Femoropopliteal Artery Occlusion | Not applicable | Recruiting | Paracelsus Medical University | 110 | 2023-09-11 | 2023-11-21 |
| Efficacy and Safety of the Regulatory Polypeptides in Patients With Peripheral Atherosclerosis. Polypeptides, Femoral-popliteal bypass grafting with a synthetic graft above the knee, Routine conservative treatment - Peripheral Arterial Occlusive Disease | Not applicable | Unknown | Ryazan State Medical University | 120 | 2023-04-01 | 2023-07-06 |
| The EasyFlype/EasyHiFlype Post Market Clinical Follow-up Study. Easy Flype/EasyHiFlype - Peripheral Artery Disease, Peripheral Arterial Occlusive Disease | Completed | CID S.p.A. | 52 | 2023-03-18 | 2026-10-22 | |
| Prospective Study of the SoundBite™ Crossing System in Complex Peripheral CTOs SoundBite™ Crossing System - Peripheral - Peripheral Arterial Occlusive Disease, Chronic Total Occlusion of Artery of the Extremities | Not applicable | Withdrawn | SoundBite Medical Solutions, Inc. | 2022-12-30 | 2023-09-14 | |
| Risk Factors for Adverse Outcomes of Endovascular Revascularization in Lower Extremity Arteriosclerosis Occlusion endovascular revascularization - Peripheral Arterial Occlusive Disease | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 500 | 2022-10-20 | 2024-03-06 | |
| Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With LEAD (IRONPAD) Ferric Carboxymaltose Injection [Injectafer], no treatment or oral iron supplementation - Anemia, Peripheral Arterial Occlusive Disease | Phase 4 | Unknown | Biobizkaia Health Research Institute | 240 | 2019-08-15 | 2023-01-05 |
| The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions Point of care screening for HPR, Ticagrelor 90mg - Peripheral Artery Disease, Clopidogrel, Poor Metabolism of | Phase 3 | Terminated | Marissa Jarosinski | 31 | 2019-08-09 | 2026-07-06 |
| The VaSecure BTK Study VaSecure™ - Peripheral Artery Disease, Peripheral Vascular Disease | Not applicable | Unknown | Vascuros Medical Pte Ltd | 46 | 2018-10-30 | 2018-10-26 |
| Lifestyle Modification Programme for Patients With Peripheral Arterial Disease Risk Factors Modification Programme, Standard Healthcare - Peripheral Arterial Occlusive Disease | Not applicable | Unknown | Western Vascular Institute, Ireland | 208 | 2018-06-01 | 2021-08-04 |
| Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD allo-APZ2-PAOD, Placebo - Peripheral Arterial Occlusive Disease | Phase 1 / Phase 2 | Terminated | RHEACELL GmbH & Co. KG | 24 | 2018-03-05 | 2020-06-29 |
| CO2-Angiography-Study to Evaluate Diagnostic and Safety to Patients With Peripher Arterial Stenotic or Occlusive Disease. Angiography - Peripheral Arterial Occlusive Disease | Not applicable | Completed | Jena University Hospital | 50 | 2017-09-01 | 2022-10-21 |
| Autologous BMMNC Combined With HA Therapy for PAOD RV-P1501 - Peripheral Arterial Occlusive Disease, Critical Limb Ischemia | Phase 1 / Phase 2 | Withdrawn | Academia Sinica, Taiwan | 2017-01-17 | 2022-03-15 |
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Peripheral Arterial Occlusive Disease 1 (55) · Peripheral Arterial Disease (10) · Chronic Limb-Threatening Ischemia (6) · Peripheral Vascular Diseases (5) · Atherosclerosis (3) · Diabetes Mellitus (3) · Intermittent Claudication (3) · Arteriosclerosis (2) · Alzheimer Disease (1) · Anemia (1) · Aortic Aneurysm, Abdominal (1) · Aortic Diseases (1) · Arterial Occlusive Diseases (1) · Cerebral Arterial Diseases (1) · Coronary Stenosis (1)
Cardiovascular Diseases (23) · Vascular Diseases (22) · Arterial Occlusive Diseases (18) · Arteriosclerosis (16) · Atherosclerosis (14) · Peripheral Vascular Diseases (13) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (8) · Ischemia (7) · Peripheral Arterial Disease (7) · Chronic Disease (6) · Disease Attributes (6) · Endocrine System Diseases (4) · Signs and Symptoms (4) · Brain Diseases (3)
Iopamidol (2) · Sildenafil Citrate (2) · Sodium Chloride (2) · iodixanol (2) · Alprostadil (1) · Angiography (1) · Angioplasty (1) · Angioplasty, Balloon (1) · Arginine (1) · Clonidine (1) · Dexmedetomidine (1) · Heparin (1) · Injections (1) · Levobupivacaine (1) · Midazolam (1)
Sanofi (4) · B. Braun Melsungen AG (3) · Flanders Medical Research Program (3) · Abbott Medical Devices (2) · Aplagon Oy (2) · Bracco Diagnostics, Inc (2) · Kantonsspital Baselland Bruderholz (2) · Paracelsus Medical University (2) · University Hospital, Angers (2) · Academia Sinica, Taiwan (1) · Baltimore VA Medical Center (1) · Biobizkaia Health Research Institute (1) · CID S.p.A. (1) · Chang Gung Memorial Hospital (1) · First Affiliated Hospital Xi'an Jiaotong University (1)
Germany (17) · United States (11) · Belgium (8) · Austria (6) · Switzerland (4) · Czechia (3) · France (3) · United Kingdom (3) · Finland (2) · Ireland (2) · Italy (2) · Netherlands (2) · Poland (2) · Russia (2) · Singapore (2)
George Adams, MD (2) · Klaus Amendt, MD (2) · Marc Bosiers, MD (2) · Patrick Peeters, MD (2) · Stephanie Rassam, MD (2) · Afshin Assadian, Prim PD Dr (1) · Alan Lumsden, MD (1) · Ana Apodaka Diez, MD (1) · Barbara Biedermann, MD (1) · Berthold Amann, MD (1) · Birgit Linnemann, M.D. (1) · Birgit Linnemann, MD (1) · Brajesh K Lal, MD (1)
PMID 21716303, PMID 18990592, PMID 20354489, PMID 22277685, PMID 23792625, PMID 28189475, PMID 28225505, PMID 30361959, PMID 30722718, PMID 31152977, PMID 32103970, PMID 32618486, PMID 32753875, PMID 32769505, PMID 32780436, PMID 33016805, PMID 33094679, PMID 33581715, PMID 33866936, PMID 33932282, PMID 34057276, PMID 35503774, PMID 37066103, PMID 41159585, PMID 41994540
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