46 completed, 13 terminated, 2 recruiting, 1 unknown. 19 Phase 4, 14 Phase 3, 6 Phase 2, 4 Not applicable, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lumason® Infusion vs. Bolus Administrations Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON], Lumason - Heart Diseases | Phase 3 | Recruiting | Bracco Diagnostics, Inc | 106 | 2024-07-10 | 2026-10-20 |
| Study With Oral Isovue in Abdominopelvic CT Iopamidol - Patients Requiring Abdominopelvic CT With Oral Administration of Contrast | Completed | Bracco Diagnostics, Inc | 218 | 2021-07-01 | 2023-02-08 | |
| Comparison of Contrast Agents in Liver Magnetic Resonance (MR) for the Detection of Hepatic Metastases Gadoxetate disodium, Gadobenate dimeglumine - Oligometastatic Disease, Liver Metastases | Phase 4 | Terminated | University of Colorado, Denver | 10 | 2021-06-22 | 2026-09-25 |
| CEUS Evaluation of Hypoxic Ischemic Injury Sulfur hexafluoride lipid-type A microspheres - Hypoxic-Ischemic Encephalopathy, Brain Ischemia Hypoxia | Phase 3 | Completed | Children's Hospital of Philadelphia | 1 | 2020-12-01 | 2025-05-14 |
| CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis Sulfur hexafluoride lipid-type A microspheres - Necrotizing Enterocolitis of Newborn, Bowel Ischemic | Phase 3 | Terminated | Children's Hospital of Philadelphia | 1 | 2020-11-04 | 2024-11-12 |
| Optimal Timing of BR55 CEUS of the Ovaries BR55 - Ovarian Cancer | Phase 2 | Terminated | Bracco Diagnostics, Inc | 3 | 2019-10-14 | 2024-08-23 |
| Thyroid Function of Pediatric Subjects Following Isovue® Administration Isovue - Hypothyroidism | Phase 4 | Terminated | Bracco Diagnostics, Inc | 17 | 2019-03-26 | 2025-07-30 |
| BR55 in Characterization of Ovarian Lesions BR55 - Ovarian Cancer | Phase 2 | Terminated | Bracco Diagnostics, Inc | 14 | 2018-12-13 | 2024-09-19 |
| Evaluation of Safety and Efficacy of ProHance in Pediatric Patients <2yrs ProHance - Central Nervous System Diseases, Central Nervous System Neoplasms | Completed | Bracco Diagnostics, Inc | 125 | 2018-11-01 | 2020-01-23 | |
| Transabdominal Ultrasound With BR55 for Characterization of Pancreatic Lesions BR55 - Pancreatic Ductal Adenocarcinoma | Phase 2 | Terminated | Bracco Diagnostics, Inc | 4 | 2018-07-19 | 2024-08-23 |
| Contrast-Enhanced Ultrasound Imaging in Diagnosing Liver Cancer in Patients With Cirrhosis Dynamic Contrast-Enhanced Ultrasound Imaging - Liver Cirrhosis | Not applicable | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 612 | 2018-01-19 | 2025-05-18 |
| Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH Intraoperative contrast-enhanced ultrasound (CEUS), Lumason - Developmental Dysplasia of the Hip | Early Phase 1 | Recruiting | Children's Hospital of Philadelphia | 125 | 2017-05-22 | 2026-04-15 |
| Retrospective Study of MRI With MULTIHANCE at 0.10 and 0.05 mmol/Kg Dose in CNS Patients MultiHance - Central Nervous System Diseases, Central Nervous System Neoplasms | Completed | Bracco Diagnostics, Inc | 352 | 2017-05-18 | 2018-07-18 | |
| Diagnostic Utility of MRI in Female Patients With Nipple Discharge: A Prospective Trial MRI - Disorder of Nipple, Breast Neoplasms | Not applicable | Terminated | Duke University | 30 | 2016-07-01 | 2020-01-07 |
| A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Iomeron - Aortic Disorders, Carotid Disease | Phase 4 | Completed | Bracco Diagnostics, Inc | 224 | 2015-12-01 | 2017-06-02 |
| Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-142 Lumason - Coronary Artery Disease | Phase 3 | Completed | Bracco Diagnostics, Inc | 174 | 2015-10-12 | 2021-07-07 |
| Evaluation of Safety and Efficacy of Lumason in Pediatric Echocardiography sulphur hexafluoride lipid-type A microspheres - Heart Disease | Phase 3 | Terminated | Bracco Diagnostics, Inc | 13 | 2015-10-01 | 2020-07-13 |
| Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-141 Lumason - Coronary Artery Disease | Phase 3 | Completed | Bracco Diagnostics, Inc | 175 | 2015-09-24 | 2021-06-11 |
| Retrospective Study of MRI in Pediatric Patients Gadobenate Dimeglumine - Central Nervous System Disease, Central Nervous System Neoplasms | Completed | Bracco Diagnostics, Inc | 90 | 2014-11-01 | 2016-07-19 | |
| Evaluation of Gd Retention in Human Bone and Skin After MultiHance or ProHance Administration Compared With Control Surgery - Gadolinium Retention | Completed | Bracco Diagnostics, Inc | 28 | 2014-10-01 | 2020-08-14 |
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Coronary Artery Disease (5) · Central Nervous System Diseases (4) · Liver Neoplasms (4) · Central Nervous System Neoplasms (3) · Coronary Stenosis (3) · Heart Diseases (3) · Prostatic Neoplasms (3) · Renal Insufficiency (3) · Acute Coronary Syndrome (2) · Brain Diseases (2) · Breast Neoplasms (2) · Carcinoma, Hepatocellular (2) · Chest Pain (2) · Diabetes Mellitus (2) · Liver Cirrhosis (2)
gadobenic acid (14) · Iopamidol (10) · contrast agent BR1 (5) · Gadolinium DTPA (4) · iodixanol (4) · gadobutrol (2) · gadoteridol (2) · Magnetic Resonance Spectroscopy (1) · Saline Solution (1) · Surgical Procedures, Operative (1) · Suspensions (1) · gadofosveset trisodium (1) · gadolinium ethoxybenzyl DTPA (1) · gadoterate meglumine (1) · iomeprol (1)
United States (49) · Italy (7) · Canada (6) · France (3) · United Kingdom (3) · Belgium (2) · China (2) · Germany (2) · Netherlands (2) · Austria (1) · Poland (1) · South Korea (1) · Switzerland (1)
Gianpaolo Pirovano, MD (11) · Maria Luigia Storto, MD (5) · Steven Sireci, M.D. (3) · Alberto Spinazzi, M.D. (2) · Gianpaolo Priovano, M.D. (2) · Maria Luigia Storto, M.D. (2) · Marie Morris (2) · Martin Krix, M.D. (2) · Melda Dolan, MD (2) · Andrej Lyshchik, MD, PhD (1) · Barry Hogstrom, M. D. (1) · Gary V. Heller, M.D., Ph.D. (1) · Gianpaolo Pirovano, M. D. (1) · Gianpaolo Pirovano, M.D. (1) · Gianpaolo Priovano, MD (1)
PMID 30808770, PMID 19306364, PMID 19556381, PMID 21163915, PMID 23042922, PMID 25300984, PMID 38860996, PMID 39835975
P30CA046934 (1), R01CA215520 (1)