23 completed, 9 recruiting, 6 not yet recruiting, 4 unknown. 33 Not applicable, 5 Phase 4, 3 Phase 3, 1 Phase 1.
Follow Opioid Consumption: new trials by email Literature Review of Opioid Consumption trials Research Report on Opioid Consumption
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS) - Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection | Not applicable | Not yet recruiting | Lebanese American University | 80 | 2026-12-01 | 2026-10-19 |
| Suzetrigine for Analgesiain Arthroscopic Rotator Cuff Repair Suzetrigine (Journavx), Matching placebo, Standard multimodal analgesia - Artroscopic Surgery, Pain Management | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-11-01 | 2026-10-08 |
| Comparison of TAP Block and Umbilical Paramedian Linea Semilunaris Block in Pediatric Laparoscopic Surgery Ultrasound-Guided Transversus Abdominis Plane Block, Ultrasound-Guided Linea Semilunaris Block - Postoperative Pain, Opioid Consumption | Not applicable | Not yet recruiting | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 56 | 2026-08-25 | 2026-09-03 |
| Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery Opioid Use Disorder, Opioid Consumption | Recruiting | University of California, San Diego | 100 | 2026-07-15 | 2026-07-17 | |
| Comparison Between Paravertebral and Erector Spinal Block Efficacy in Robotic Thoracic Surgeries Paravertebral Nerve Block, ESP block group - Post Operative Analgesia, Regional Anaesthesia | Not applicable | Active not recruiting | Soroka University Medical Center | 60 | 2026-07-01 | 2026-08-24 |
| The Effects of Regional Anaesthesia Techniques on Hemidiaphragm Paralysis, Postoperative Recovery Quality, Opioid Consumption, and Pain Scores İnterscalene block group, Erector spinae plane block group, Costoclavicular block group - Regional Anaesthesia, Arthroscopic Shoulder Surgery | Recruiting | Antalya Training and Research Hospital | 88 | 2026-04-21 | 2026-05-11 | |
| Opioid-Sparing Joint Replacement Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia - Pain Management, Opioid Consumption | Phase 3 | Recruiting | Emory University | 120 | 2026-03-19 | 2026-04-17 |
| Effect of Rectus Block Timing on Opioid Use Early bilateral rectus sheat block, Late bilateral rectus sheat block - Prostate Cancer, Pain Management | Not applicable | Completed | Koc University Hospital | 50 | 2026-03-15 | 2026-08-03 |
| Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery Deep Parasternal Intercostal Plane Block, Standard Multimodal Analgesia - Postoperative Pain, Sternotomy | Not applicable | Recruiting | Gaziantep City Hospital | 80 | 2026-02-12 | 2026-03-04 |
| Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial PENG plus LFCN block, PENG plus WI - Arthropathy of Hip, Hip Arthropathy | Not applicable | Recruiting | Ospedale Edoardo Bassini | 102 | 2026-01-26 | 2026-03-25 |
| Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery Fixed-rate basal infusion mode, Time-programmed decremental background infusion mode - Surgery, Pain Management | Not applicable | Recruiting | Beijing Tiantan Hospital | 450 | 2025-12-30 | 2026-04-06 |
| Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery Fixed-rate basal infusion mode, Variable-rate feedback infusion mode - Surgery, Pain Management | Not applicable | Recruiting | Beijing Tiantan Hospital | 1170 | 2025-12-30 | 2026-06-12 |
| Transnasal Sphenopalatine Ganglion Block for Postoperative Pain and Recovery in Tonsillectomy (TONwoPA) Transnasal Transmucosal Sphenopalatine Ganglion Block, Lidocaine %5, Saline (0.9% NaCl) - Post Tonsillectomy Pain, Post Operative Analgesia | Not applicable | Completed | Ankara University | 26 | 2025-08-30 | 2026-10-13 |
| Ultrasound-Guided Erector Spinae Plane Block in Major Spinal Surgery Ultrasound-guided erector spinae plane block - Perioperative Bleeding, Opioid Consumption | Not applicable | Completed | Diskapi Yildirim Beyazit Education and Research Hospital | 120 | 2025-07-26 | 2026-07-10 |
| Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB) Single level SPSIPB, Two-level SPSIPB - Opioid Consumption, Demographic Data | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 50 | 2025-07-15 | 2025-07-03 |
| Effects of Erector Spinae Plane Block on Opioid Consumption, Anesthetic Consumption and Hemodynamics in Lumbar Disc Herniation Surgeries. PREOPERATIVE ESPB, INTRAOPERATIVE ESPB - Erector Spina Plan Block, Opioid Consumption | Not applicable | Completed | Ankara Ataturk Sanatorium Training and Research Hospital | 60 | 2025-04-01 | 2026-11-03 |
| The Effects of ESP Block and Mid-Transverse Process to Pleura Block on Postoperative Opioid Consumption and Quality of Recovery Numeretic rating scale (NRS), Quality of Results (QoR-40), Opioid consuption - Opioid Consumption, Quality of Recovery(QoR-40), Preoperative and Postoperative | Not applicable | Not yet recruiting | Aydin Adnan Menderes University | 126 | 2025-02-15 | 2025-02-07 |
| Comparison of Bi-Level Erector Spinae Plane Block (ESPB) and Modified Thoraco Abdominal Plane Block (M-TAPA) Group Bi-level ESPB, Group M-TAPA block - Opioid Consumption, Numerical Rating Scale | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 50 | 2024-12-30 | 2024-12-19 |
| Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients Using ultrasound for penile nerve block, Dorsal Penile Block Anesthesia using landmarks - Circumcision, Ultrasound | Not applicable | Recruiting | Centre Hospitalier Universitaire Vaudois | 216 | 2024-11-29 | 2026-03-27 |
| Superficial vs Deep Serratus Anterior Plane Block for Analgesia After Mammoplasty Superficial Serratus Anterior Plane Block, Deep Serratus Anterior Plane Block - Postoperative Pain Management, Analgesia, Postoperative | Not applicable | Active not recruiting | Başakşehir Çam & Sakura City Hospital | 58 | 2024-11-15 | 2026-03-31 |
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Pain, Postoperative (19) · Agnosia (11) · Pain (3) · Acute Pain (2) · Appendicitis (2) · Breast Neoplasms (2) · Opioid-Related Disorders (2) · Anxiety Disorders (1) · Bites and Stings (1) · Depression, Postpartum (1) · Head and Neck Neoplasms (1) · Hemorrhage (1) · Obesity (1) · Obesity, Morbid (1) · Pneumoperitoneum (1)
Pathological Conditions, Signs and Symptoms (31) · Signs and Symptoms (30) · Neurologic Manifestations (29) · Pathologic Processes (20) · Pain (19) · Postoperative Complications (18) · Nervous System Diseases (11) · Neurobehavioral Manifestations (11) · Perceptual Disorders (11) · Neoplasms (5) · Neoplasms by Site (5) · Mental Disorders (4) · Chemically-Induced Disorders (3) · Urogenital Diseases (3) · Body Weight (2)
Lidocaine (4) · Sodium Chloride (3) · Acetaminophen (2) · Bupivacaine (2) · Gabapentin (2) · Oxycodone (2) · Population Groups (2) · Saline Solution (2) · Saposins (2) · Anesthesia, Conduction (1) · Anesthesia, General (1) · Celecoxib (1) · Fentanyl (1) · Glucose (1) · Intravital Microscopy (1)
Zonguldak Bulent Ecevit University (5) · Ankara Etlik City Hospital (3) · Aydin Adnan Menderes University (2) · Başakşehir Çam & Sakura City Hospital (2) · Beijing Tiantan Hospital (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · Medical University of Warsaw (2) · AdventHealth (1) · Ankara Ataturk Sanatorium Training and Research Hospital (1) · Ankara City Hospital Bilkent (1) · Ankara University (1) · Antalya Training and Research Hospital (1) · Ataturk University (1) · Case Comprehensive Cancer Center (1) · Centre Hospitalier Universitaire Vaudois (1)
Turkey (Türkiye) (22) · United States (5) · Canada (4) · China (4) · Poland (2) · Greece (1) · Israel (1) · Italy (1) · Lebanon (1) · Switzerland (1) · Taiwan (1)
Ajay Premkumar, MD (1) · Amir Kachooei, MD PhD (1) · Anton Chau, MD (1) · Arzu Karaveli (1) · Bayram Akdag (1) · Chamaidi Sarakatsianou (1) · Chien-Chung Huang, MD (1) · Daniel Katz, MD (1) · Fatih Duygun (1) · Franco Carli, MD, professor (1) · Franco Carli, Professor (1) · Funda Atar, MD (1)
PMID 30396100, PMID 32955601, PMID 33078388, PMID 33786681, PMID 34243719, PMID 35991781, PMID 38762396, PMID 39794723, PMID 40275145, PMID 41226876, PMID 42272993, PMID 42665353, PMID 42677258