22 completed, 5 unknown, 1 not yet recruiting, 1 recruiting. 31 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 31 | Completed 22, Unknown 5, Not yet recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Muscle Hypertonia: new trials by email Literature Review of Muscle Hypertonia trials Research Report on Muscle Hypertonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities Cryoneurolysis, Botulinum toxin - Centreal Neurological Condition, Acquired Brain Injury (Including Stroke) | Phase 4 | Recruiting | Oxford University Hospitals NHS Trust | 50 | 2025-12-02 | 2026-11-05 |
| Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury Early baclofen Intervention, Usual routine care - Traumatic Spinal Cord Injury | Phase 4 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 55 | 2024-12-01 | 2024-08-21 |
| The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity Botulinum toxin type A, %0,9 NaCl - Cerebrovascular Disorders, Spasticity, Muscle | Phase 4 | Withdrawn | Sisli Hamidiye Etfal Training and Research Hospital | 2023-05-25 | 2023-11-22 | |
| Effect of Botulinum Toxin on Selective Motor Control and Pain in Diplegic Cerebral Palsy OnabotulinumtoxinA, Conventional Physical Therapy - Cerebral Palsy Spastic Diplegia | Phase 4 | Completed | Gaziosmanpasa Research and Education Hospital | 40 | 2022-08-25 | 2026-07-28 |
| The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination Botox - Stroke, Muscle Spasticity | Phase 4 | Terminated | Weill Medical College of Cornell University | 4 | 2018-06-15 | 2021-12-29 |
| Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings Botulinum neurotoxin (BTX), Physical Therapy, Standard BTX injection (ultrasound guided) - Spasticity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 17 | 2017-11-21 | 2020-11-05 |
| Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity Ultrasonography guidance injection of Meditoxin®., Electrical stimulation guidance injection of Meditoxin®., Manual needle placement injection of Meditoxin®. - Muscle Spasticity | Phase 4 | Completed | Medy-Tox | 59 | 2016-05-30 | 2019-03-29 |
| Intrathecal (IT) Baclofen Drug Distribution Baclofen bolus injection - Muscle Spasticity | Phase 4 | Completed | Vanderbilt University | 27 | 2016-04-22 | 2022-02-22 |
| Does Botulinum Toxin A Make Walking Easier in Children With Cerebral Palsy? botox, placebo - Cerebral Palsy, Muscle Spasticity | Phase 4 | Completed | St. Olavs Hospital | 61 | 2015-09-01 | 2022-01-11 |
| Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy WalkAide - Cerebral Palsy, Congenital, Muscle Spasticity | Phase 4 | Unknown | Tel-Aviv Sourasky Medical Center | 20 | 2015-05-01 | 2015-06-03 |
| Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment botulinum A toxin, Baclofen, Placebo toxin - Muscle Spasticity | Phase 4 | Completed | University Hospital, Toulouse | 184 | 2015-04-01 | 2026-04-06 |
| Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot IncobotulinumtoxinA, OnabotulinumtoxinA - Stroke Rehabilitation, Stroke Rehabilitation Spasticity Management | Phase 4 | Completed | Parc de Salut Mar | 20 | 2015-01-01 | 2017-10-20 |
| Myobloc Atrophy Study Botox, MYOBLOC - Spasticity Secondary to Either a Disorder or Trauma, Spinal Cord Injury (SCI) | Phase 4 | Completed | Georgetown University | 10 | 2014-05-01 | 2015-12-16 |
| Upper Extremity Rehabilitation Using Robot and Botulinum Toxin Early Inmotion and Botox, Botox, then Inmotion, Inmotion, then Botox - Stroke, Spasticity | Phase 4 | Unknown | National Rehabilitation Center, Seoul, Korea | 348 | 2014-03-01 | 2014-08-29 |
| Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke Tenotomy of the proximal rectus femoris tendon, Botulinum Toxin injection in the rectus femoris muscle - Stroke, Spasticity | Phase 4 | Unknown | University Hospital of Mont-Godinne | 20 | 2014-03-01 | 2014-04-15 |
| The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults BoNT-A injection - Stroke, Muscle Spasticity | Phase 4 | Unknown | Sir Run Run Shaw Hospital | 30 | 2014-01-01 | 2015-07-22 |
| Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients incabotulinumtoxinA, Placebo - Muscle Spasticity, Multiple Sclerosis | Phase 4 | Completed | Multiple Sclerosis Center of Northeastern New York | 27 | 2013-11-01 | 2017-03-22 |
| MEDITOXIN® Treatment in Subjects With Post-Stroke Upper Limb Spasticity Meditoxin - Spasticity, Muscle | Phase 4 | Completed | Medy-Tox | 120 | 2013-09-06 | 2019-04-09 |
| Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Transcranial magnetic stimulation - Spasticity, Multiple Sclerosis, Stroke, Trauma | Phase 4 | Unknown | Russian Academy of Medical Sciences | 60 | 2013-02-01 | 2014-11-07 |
| A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients Sativex, Placebo - Multiple Sclerosis, Spasticity | Phase 4 | Completed | Jazz Pharmaceuticals | 121 | 2012-01-01 | 2023-01-12 |
Showing 20 of 31. Sign in to see all of them.
Muscle Spasticity (31) · Stroke (14) · Cerebral Palsy (6) · Spinal Cord Injuries (5) · Multiple Sclerosis (4) · Pain (4) · Brain Injuries (3) · Wounds and Injuries (3) · Anxiety Disorders (1) · Cerebrovascular Disorders (1) · Colic (1) · Deglutition Disorders (1) · Depressive Disorder, Major (1) · Developmental Disabilities (1) · Dysthymic Disorder (1)
Muscular Diseases (31) · Musculoskeletal Diseases (31) · Nervous System Diseases (31) · Neurologic Manifestations (31) · Neuromuscular Manifestations (31) · Pathological Conditions, Signs and Symptoms (31) · Signs and Symptoms (31) · Central Nervous System Diseases (22) · Brain Diseases (20) · Cardiovascular Diseases (15) · Vascular Diseases (15) · Cerebrovascular Disorders (14) · Brain Damage, Chronic (6) · Trauma, Nervous System (6)
Botulinum Toxins, Type A (19) · incobotulinumtoxinA (4) · Baclofen (3) · Botulinum Toxins (3) · abobotulinumtoxinA (2) · 3-deoxyglycero-galacto-nonulosonic acid (1) · Amitriptyline (1) · Clonazepam (1) · Diazepam (1) · Fructose (1) · Gabapentin (1) · Lamotrigine (1) · Nerve Block (1) · Pharmaceutical Preparations (1) · Physical Therapy Modalities (1)
Medy-Tox (3) · Ipsen (2) · Sathbhavana Brain Clinic (2) · The University of Texas Health Science Center, Houston (2) · Vanderbilt University (2) · Allergan (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Gaziosmanpasa Research and Education Hospital (1) · Georgetown University (1) · Jazz Pharmaceuticals (1) · MedtronicNeuro (1) · Multiple Sclerosis Center of Northeastern New York (1) · National Rehabilitation Center, Seoul, Korea (1) · Oxford University Hospitals NHS Trust (1) · Parc de Salut Mar (1)
United States (9) · South Korea (3) · United Kingdom (3) · Belgium (2) · Canada (2) · France (2) · Germany (2) · Spain (2) · Australia (1) · Austria (1) · China (1) · Czechia (1) · Hong Kong (1) · India (1) · Italy (1)
Charles H. Bombardier, PhD (1) · David Charles, MD (1) · Esther Duarte, PhD (1) · Eun S Park, Ph D (1) · Fernando Pagan, MD (1) · Gerard E Francisco, MD (1) · Jesse R. Fann, MD, MPH (1) · Joon-Ho Shin, MS (1) · Keith R Edwards, MD (1) · Michael O'Dell, M.D. (1)
PMID 10077661, PMID 10641699, PMID 10695888, PMID 10811692, PMID 12167681, PMID 12525714, PMID 14684785, PMID 18355307, PMID 20111849, PMID 2023770, PMID 20358216, PMID 21174051, PMID 21255766, PMID 22371239, PMID 22440484, PMID 2252363, PMID 2297305, PMID 23192713, PMID 23480980, PMID 24151639, PMID 25607727, PMID 25613597, PMID 29326296, PMID 30354975, PMID 34532852, PMID 39058740, PMID 40050906, PMID 7964805, PMID 8168656, PMID 8260129, PMID 8670002, PMID 8857723, PMID 8916345
2014 (1)