48 completed, 9 unknown, 6 recruiting, 3 active not recruiting. 55 Not applicable, 3 Phase 2, 3 Phase 4, 1 Early Phase 1, 1 Phase 1.
Follow Fructose: new trials by email Literature Review of Fructose trials Research Report on Fructose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fructose for Acute Ischemic Stroke 10% Fructose Injection - Acute Ischemic Stroke | Phase 2 | Active not recruiting | Ji Xunming,MD,PhD | 46 | 2026-06-05 | 2026-06-18 |
| Fructose and (Aging) Fructose, Glucose - Intestinal Permeability, Immune Response | Not applicable | Recruiting | University of Vienna | 32 | 2026-04-01 | 2026-08-11 |
| Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting. No breakfast, Breakfast (0% Fructose), Breakfast (50% fructose) - Carbohydrate Metabolism, Hepatic Glycogen Storage | Not applicable | Not yet recruiting | Manchester Metropolitan University | 12 | 2026-03-01 | 2026-03-17 |
| Glucose-fructose Ratio Pilot Glucose and fructose (one-to-one), Glucose and fructose (two-to-one) - Exercise Metabolism | Not applicable | Completed | University of Bath | 11 | 2026-01-14 | 2026-10-26 |
| Effect of Low Dose Galactose on Glycaemia and Glucose Kinetics galactose, fructose, Glucose Powder - Glucose | Not applicable | Recruiting | University of Bath | 25 | 2026-01-01 | 2026-07-08 |
| Fructose is a Metabolic and Inflammatory Pathogenic Factor in Metabolic Dysfunction-associated Steatohepatitis (MASH) fructose, glucose - MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis | Not applicable | Recruiting | Queen Mary University of London | 72 | 2025-06-30 | 2026-07-31 |
| Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I Fructose, Fructose and galactose - Glycogen Storage Disease Type I | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 20 | 2025-04-24 | 2026-05-12 |
| Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose Sucrose, Glucose, Fructose - Gastrointestinal Hormones, Glycemic Control | Not applicable | Active not recruiting | University Hospital, Basel, Switzerland | 20 | 2025-02-06 | 2026-09-03 |
| Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS (R)-3-hydroxybutyl (R)-3-hydroxybutyrate), Maltodextrin, Fructose, Pectin, Sodium alginate, Sodium chloride - Schizophrenia and Related Disorders, Psychosis | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 28 | 2024-12-01 | 2026-04-27 |
| High Fructose Diet, the Gut Microbiome, and Metabolic Health Fructose, glucose - MASLD, Type 2 Diabetes | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 30 | 2024-10-08 | 2025-12-17 |
| The Role of Sugars in Fat Accumulation in the Liver 150g of fat with glucose, 150g of fat with fructose, 150g of fat with sucrose - Fatty Liver Disease | Not applicable | Recruiting | Institute for Clinical and Experimental Medicine | 40 | 2024-06-20 | 2024-12-30 |
| Exogenous Ketosis During Bed Rest in Older Adults ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate, carbohydrate-fat placebo (fructose, corn and canola oil 50:50 ratio) - Muscle Protein Synthesis, Muscle Atrophy | Not applicable | Completed | McGill University | 30 | 2023-02-27 | 2024-02-07 |
| BaRiatric Surgery AnD FRUctose Handeling In Obese subjecTs fructose - Insulin Resistance | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 20 | 2023-02-05 | 2023-02-08 |
| Effect of Postoperative Oral Carbohydrate Administration in Total Knee Arthroplasty Elderly Patients 100ml carbohydrate containing 12.5g maltodextrin, fructose and glucose, Routine feeding - Total Knee Arthroplasty, Postoperative Oral Carbohydrates | Early Phase 1 | Unknown | Nanjing First Hospital, Nanjing Medical University | 64 | 2022-11-22 | 2023-05-01 |
| A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors Cohort 1: HFCS (fructose) fed, Cohort 2: D-Xylose (xylose-fed) - Colorectal Tumors | Not applicable | Completed | Weill Medical College of Cornell University | 12 | 2022-02-16 | 2024-11-06 |
| Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents Erythritol, Sucrose, Glucose - Insulin Resistance, Glucose Tolerance | Not applicable | Active not recruiting | University Hospital, Basel, Switzerland | 30 | 2021-08-18 | 2026-09-30 |
| Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers Fructose/glucose/xylitol/saccharose - Acute Kidney Injury | Not applicable | Unknown | Medical University of Gdansk | 30 | 2020-03-09 | 2020-03-17 |
| Fructose in Exercising Individuals With Type 1 Diabetes Using Insulin Degludec Fructose, Plain water - Type 1 Diabetes Mellitus, Diabetes Complications | Not applicable | Completed | Insel Gruppe AG, University Hospital Bern | 15 | 2019-01-04 | 2019-09-20 |
| Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle Fructose and physical inactivity - Vascular Diseases | Not applicable | Completed | University of Missouri-Columbia | 52 | 2018-11-30 | 2022-08-17 |
| Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity Fructose-containing Sugars - Body Weight, Obesity | Unknown | John Sievenpiper | 1 | 2018-09-04 | 2019-01-15 |
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Insulin Resistance (9) · Diabetes Mellitus (6) · Diabetes Mellitus, Type 2 (5) · Dyslipidemias (5) · Metabolic Syndrome (5) · Non-alcoholic Fatty Liver Disease (5) · Obesity (5) · Cardiovascular Diseases (4) · Overweight (4) · Body Weight (3) · Exploratory Behavior (3) · Fatty Liver (3) · Hypertriglyceridemia (3) · Pain (3) · Sedentary Behavior (3)
University Hospital, Basel, Switzerland (5) · University of Toronto (4) · University of Lausanne (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Federal University of Rio Grande do Sul (2) · Insel Gruppe AG, University Hospital Bern (2) · Institute for Clinical and Experimental Medicine (2) · Rockefeller University (2) · The Rogosin Institute (2) · Unilever R&D (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Bath (2) · University of California, Davis (2) · University of Nottingham (2) · Albert Einstein College of Medicine (1)
United States (12) · Switzerland (11) · Canada (9) · United Kingdom (7) · Netherlands (5) · Austria (3) · China (3) · Brazil (2) · Czechia (2) · Italy (2) · Sweden (2) · Denmark (1) · Finland (1) · New Zealand (1) · Poland (1)
Christoph Beglinger, MD (2) · Kimber L Stanhope, Ph.D, R.D. (2) · Lisa Hudgins, MD (2) · Luc Tappy, MD (2) · Anne Christin Meyer-Gerspach, PD, PhD (1) · Camila Manrique Acevedo, MD (1) · Christoph Beglinger, Prof (1) · Christoph Stettler, MD (1) · David Green (1) · Dita Pajuelo, PhD (1) · Duo Li, Doctor (1) · Giles AD Major, BM BCh MA MRCP (1)
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R01DK079974 (1), R01DK137968 (1), R01HL075675 (1), R01HL091333 (1), R01HL107256 (1)