29 completed, 6 unknown, 2 active not recruiting, 2 not yet recruiting. 43 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 43 | Completed 29, Unknown 6, Active not recruiting 2, Not yet recruiting 2, Terminated 2, Recruiting 1, Withdrawn 1 |
Follow Meningitis: new trials by email Literature Review of Meningitis trials Research Report on Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2027-01-01 | 2026-10-28 |
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons Serogroup B meningococal vaccine - Meningococcal Meningitis, Serogroup B, Transgender Persons | Phase 4 | Recruiting | University Ghent | 250 | 2025-01-31 | 2026-01-20 |
| Clinical Study of the Safety of Menhycia® in 3-Month-Old Infants MCV4 - Epidemic Meningitis | Phase 4 | Completed | CanSino Biologics Inc. | 3011 | 2024-06-12 | 2026-08-13 |
| A Study on the Immune Response and Safety of a Vaccine Against N. Meningitidis Serogroup B Infection in Healthy Infants From 2 Months of Age rMenB+OMV NZ - Meningitis, Meningococcal | Phase 4 | Active not recruiting | GlaxoSmithKline | 50 | 2023-11-10 | 2026-04-06 |
| Phase IV Clinical Study of Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) MCV4 - Epidemic Meningitis | Phase 4 | Active not recruiting | CanSino Biologics Inc. | 660 | 2023-09-20 | 2026-03-04 |
| Amphotericin B for Non-HIV Cryptococcal Meningitis Patients Amphotericin B 0.5 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks., Amphotericin B 0.7 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks. - Cryptococcal Meningitis, Antifungal Agents | Phase 4 | Unknown | Huashan Hospital | 250 | 2023-08-13 | 2023-12-21 |
| A Study to Demonstrate Non-inferior Immunogenicity of Yuxi Walvax MPV ACYW® Vaccine in Healthy Subjects Aged 2-10 Years Yuxi Walvax MPV ACYW® vaccine, Sanofi Pasteur Menactra® vaccine - Neisseria Meningitides Meningitis | Phase 4 | Completed | Walvax Biotechnology Co., Ltd. | 260 | 2020-12-23 | 2023-07-07 |
| Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in Frequent Platelets Donors Menactra - Preventive Immunization; Meningitis | Phase 4 | Unknown | Brigham and Women's Hospital | 102 | 2020-03-12 | 2022-11-15 |
| Ciprofloxacin for the Prevention of Meningococcal Meningitis 2018 Ciprofloxacin - Meningitis, Meningococcal | Phase 4 | Withdrawn | Epicentre | 2019-03-01 | 2019-08-14 | |
| Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population Bexsero® (meningitis B vaccine), Menveo® (meningitis ACWY vaccine) - Hiv, Meningitis, Meningococcal | Phase 4 | Unknown | St George's, University of London | 55 | 2019-02-21 | 2019-04-10 |
| A Sourcing Study to Collect Human Blood Samples From Healthy Adults rMenB+OMV NZ vaccine, Meningococcal Groups A, C, W and Y Conjugate Vaccine (MenACWY) - Meningitis, Meningococcal | Phase 4 | Completed | GlaxoSmithKline | 1021 | 2018-03-08 | 2023-07-17 |
| Ciprofloxacin for the Prevention of Meningococcal Meningitis Ciprofloxacin - Meningitis, Meningococcal | Phase 4 | Completed | Epicentre | 300 | 2017-04-22 | 2018-02-08 |
| Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine - Meningitis, Meningococcal Meningitis | Phase 4 | Completed | Sanofi Pasteur, a Sanofi Company | 1311 | 2016-07-21 | 2022-04-25 |
| Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Liposomal amphotericin B - Cryptococcal Meningitis | Phase 4 | Unknown | Hui Bu | 40 | 2016-01-01 | 2016-02-22 |
| Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine - Meningitis, Meningococcal Meningitis | Phase 4 | Completed | Sanofi Pasteur, a Sanofi Company | 110 | 2015-12-01 | 2016-11-07 |
| The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Dexamethasone acetate - Tuberculous Meningitis | Phase 4 | Unknown | Hui Bu | 200 | 2015-11-01 | 2015-10-29 |
| Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate - Meningitis, Meningococcal Meningitis | Phase 4 | Completed | Sanofi Pasteur, a Sanofi Company | 60 | 2015-10-20 | 2017-11-06 |
| Investigating the Immune Response to 4CMenB in Infants 4CMenB - Meningitis | Phase 4 | Completed | University of Oxford | 187 | 2014-07-21 | 2018-10-19 |
| Pertussis and Meningitis C Concomitant Vaccination in Adolescents Meningococcal vaccine, Pertussis containing vaccine - Pertussis, Meningitis | Phase 4 | Completed | Public Health England | 400 | 2013-09-01 | 2019-03-22 |
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Meningitis, Meningococcal (16) · Meningococcal Infections (16) · Meningitis, Cryptococcal (5) · Whooping Cough (4) · Acquired Immunodeficiency Syndrome (3) · HIV Infections (3) · Tetanus (3) · Cryptococcosis (2) · Diphtheria (2) · Meningitis, Bacterial (2) · Coitus (1) · Drug-Related Side Effects and Adverse Reactions (1) · Haemophilus Infections (1) · Hypothermia (1)
Nervous System Diseases (43) · Neuroinflammatory Diseases (43) · Infections (36) · Bacterial Infections and Mycoses (34) · Bacterial Infections (29) · Central Nervous System Diseases (26) · Central Nervous System Infections (26) · Gram-Negative Bacterial Infections (25) · Neisseriaceae Infections (24) · Central Nervous System Bacterial Infections (20) · Meningitis, Bacterial (18) · Meningococcal Infections (8) · Gram-Positive Bacterial Infections (6) · Central Nervous System Fungal Infections (5)
Meningococcal Vaccines (12) · 4CMenB vaccine (4) · Ciprofloxacin (2) · Heptavalent Pneumococcal Conjugate Vaccine (2) · Acetaminophen (1) · Acyclovir (1) · Amphotericin B (1) · Boostrix (1) · Cytarabine (1) · Fluconazole (1) · Gentamicins (1) · Guidelines as Topic (1) · Hypothermia, Induced (1) · Lamivudine (1) · MenACWY (1)
Sanofi Pasteur, a Sanofi Company (8) · Epicentre (3) · CanSino Biologics Inc. (2) · GlaxoSmithKline (2) · Hui Bu (2) · University of Minnesota (2) · University of Oxford (2) · Assistance Publique - Hôpitaux de Paris (1) · Botswana-UPenn Partnership (1) · Brigham and Women's Hospital (1) · Centers for Disease Control and Prevention (1) · Chiron Corporation (1) · Huashan Hospital (1) · Jacob Bodilsen (1) · Johns Hopkins Bloomberg School of Public Health (1)
United States (8) · United Kingdom (5) · China (4) · Niger (3) · Uganda (3) · France (2) · Mali (2) · South Korea (2) · Angola (1) · Australia (1) · Bangladesh (1) · Belgium (1) · Botswana (1) · Canada (1) · Chad (1)
Ahmet Tutuncu, MD, PhD (1) · Andrew J Pollard, BA, MBBS, FRCPCH, PhD (1) · Andrew J Pollard, PhD (1) · Andrew J. Pollard, MBBS, FRCPCH, PhD (1) · Brian Greenwood, MD (1) · Catherine Cosgrove, MBBS PhD (1) · David B Meya, MMed (1) · David R Boulware, MD, MPH (1) · Dominique A Caugant, PhD (1) · Eric Stern, MD (1) · Gary Darmstadt, MD (1)
PMID 19048025, PMID 23362285, PMID 24105303, PMID 24963568, PMID 28532434, PMID 28646924, PMID 29944651, PMID 30325463, PMID 30399034, PMID 31235630, PMID 31319498, PMID 31377946, PMID 31504335, PMID 32246138, PMID 32843994, PMID 33210468, PMID 33439463, PMID 35288394, PMID 37088964, PMID 37172200, PMID 37401618, PMID 39972326
2017 (1), U01AI089244 (1), U01GH000517 (1)