132 completed, 23 unknown, 17 recruiting, 9 not yet recruiting. 68 Phase 3, 52 Phase 2, 20 Phase 4, 15 Phase 1, 14 Not applicable.
Follow Meningitis, Bacterial: new trials by email Literature Review of Meningitis, Bacterial trials Research Report on Meningitis, Bacterial
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 9 | 2026-09-21 | 2026-09-17 |
| A Clinical Trial of the ACYW135 Group Meningococcal Polysaccharide-Conjugated Vaccine (CRM197 Vector) Previously vaccinated with MCV4 (CanSino), Previously vaccinated with MPSV4 (LvZhu) - Epidemic Meningitis | Not yet recruiting | CanSino Biologics Inc. | 180 | 2026-09-15 | 2026-08-03 | |
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Metagenomic Analysis of the Pharynx in High Risk Partners Gonorrhea, Neisseria Gonorrhea | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 100 | 2026-07-14 | 2026-06-30 | |
| Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT) - Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP) | Phase 2 | Not yet recruiting | BioVersys AG | 120 | 2026-07-01 | 2026-02-24 |
| Prediction of Infectious Agents in the Biofire® FilmArray bioMérieux Meningitis/Encephalitis Panel Based on Clinical Syndrome and Cerebrospinal Fluid Parameters: a Diagnostic Stewardship Proposal. Biofire FilmArray Meningitis/Encephalitis Panel - Meningitis, Encephalitic Infection | Not applicable | Recruiting | Federal University of Health Science of Porto Alegre | 182 | 2026-04-13 | 2026-08-21 |
| Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 86 | 2026-04-01 | 2026-03-27 |
| Acute Treatment and Long-term Assessment of Adult Infectious Meningitis Viral Meningitis, Bacterial Meningitis | Recruiting | Hospital Israelita Albert Einstein | 624 | 2026-03-30 | 2026-08-13 | |
| Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis HRZE, HRZE plus Alpe375, HRZE plus AlpE500 - Tuberculosis Meningitis | Phase 2 | Not yet recruiting | BioVersys AG | 64 | 2026-03-30 | 2026-03-03 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 3-5 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 880 | 2026-03-25 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 12-23 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 6-11 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 2-6 Years experimental vaccine, active comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Active not recruiting | Sinovac Biotech Co., Ltd | 660 | 2026-03-22 | 2026-08-10 |
| Phase Ia Clinical Trial of Group ACYW135X Meningococcal Conjugate Vaccine high-dose Group ACYW135X Meningococcal Conjugate Vaccine, medium-dose Group ACYW135X Meningococcal Conjugate Vaccine, low-dose Group ACYW135X Meningococcal Conjugate Vaccine - Meningococcal Meningitis | Phase 1 | Not yet recruiting | Sinovac Life Sciences Co., Ltd. | 150 | 2026-01-21 | 2026-01-28 |
| Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis-Haemophilus influenzae type b (Conjugate)-Meningococcal Group ACYW135 (Conjugate) Combined Vaccine (DTcP-Hib-MCV4), DTcP-Hib-MCV4, Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis (DTcP) - Diphtheria, Tetanus and Acellular Pertussis, Epidemic Meningitis | Phase 1 | Recruiting | CanSino Biologics Inc. | 260 | 2025-12-19 | 2025-12-31 |
| Febrile Infants Swedish Study Febrile Illness Acute, Meningitis, Bacterial | Recruiting | Region Skane | 2000 | 2025-12-01 | 2026-04-02 | |
| Adjunctive Doxycycline for Central Nervous System Tuberculosis Doxycycline, Placebo, Anti Tuberculosis Drug - Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology) | Phase 2 | Recruiting | National University Hospital, Singapore | 200 | 2025-08-21 | 2026-06-01 |
| Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis CSF sample - Nosocomial Infection | Not applicable | Recruiting | University Hospital, Toulouse | 185 | 2025-02-12 | 2025-12-31 |
| Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons Serogroup B meningococal vaccine - Meningococcal Meningitis, Serogroup B, Transgender Persons | Phase 4 | Recruiting | University Ghent | 250 | 2025-01-31 | 2026-01-20 |
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Meningitis, Meningococcal (125) · Meningitis (60) · Meningococcal Infections (60) · Tuberculosis, Meningeal (30) · Tuberculosis (8) · Diphtheria (7) · Tetanus (7) · Whooping Cough (6) · Central Nervous System Infections (5) · Haemophilus Infections (5) · Meningitis, Pneumococcal (4) · Sepsis (4) · Urinary Tract Infections (4) · Bacterial Infections (3)
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Meningococcal Vaccines (31) · 4CMenB vaccine (10) · MenACWY-CRM vaccine (7) · Rifampin (7) · Linezolid (6) · Heptavalent Pneumococcal Conjugate Vaccine (5) · Aspirin (4) · Isoniazid (4) · Vaccines (4) · measles, mumps, rubella, varicella vaccine (4) · Chickenpox Vaccine (3) · Ciprofloxacin (3) · Dexamethasone (3) · Hepatitis A Vaccines (3) · Hepatitis B Vaccines (3)
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Alberto Yataco, MD (2) · Guy Thwaites, MD (2) · Lin Du (2) · Robert C Read (2) · Rovina Ruslami, M.D., PhD (2)
PMID 35164991, PMID 29253560, PMID 33283229, PMID 36462524, PMID 41574175, PMID 17173226, PMID 17548138, PMID 19048025, PMID 19476428, PMID 19812260, PMID 20164251, PMID 20189491, PMID 20655261, PMID 21148522, PMID 21177912, PMID 21339701, PMID 21389149, PMID 22094635, PMID 22174748, PMID 22569484, PMID 22832260, PMID 23103177, PMID 23114372, PMID 23324563, PMID 23352429, PMID 24105303, PMID 24614374, PMID 24873986, PMID 24949994, PMID 25075804, PMID 25077420, PMID 25308927, PMID 25424810, PMID 25483566, PMID 25703312, PMID 25969894, PMID 26039810, PMID 26075813, PMID 26135245, PMID 26232542, PMID 26479973, PMID 26756390, PMID 26926644, PMID 27522443, PMID 27745812, PMID 28137820, PMID 28290120, PMID 28318767, PMID 28580917, PMID 28646924
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