144 completed, 28 unknown, 22 recruiting, 12 not yet recruiting. 72 Phase 3, 55 Phase 2, 22 Phase 4, 21 Not applicable, 16 Phase 1.
Follow Central Nervous System Bacterial Infections: new trials by email Literature Review of Central Nervous System Bacterial Infections trials Research Report on Central Nervous System Bacterial Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis Minocycline, Minocycline placebo, Aqueous crystalline penicillin G - Neurosyphilis | Phase 3 | Not yet recruiting | Beijing Ditan Hospital | 778 | 2026-11-15 | 2026-10-29 |
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 9 | 2026-09-21 | 2026-09-17 |
| A Clinical Trial of the ACYW135 Group Meningococcal Polysaccharide-Conjugated Vaccine (CRM197 Vector) Previously vaccinated with MCV4 (CanSino), Previously vaccinated with MPSV4 (LvZhu) - Epidemic Meningitis | Not yet recruiting | CanSino Biologics Inc. | 180 | 2026-09-15 | 2026-08-03 | |
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 20 | 2026-07-27 | 2026-10-08 |
| Metagenomic Analysis of the Pharynx in High Risk Partners Gonorrhea, Neisseria Gonorrhea | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 100 | 2026-07-14 | 2026-06-30 | |
| Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT) - Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP) | Phase 2 | Not yet recruiting | BioVersys AG | 120 | 2026-07-01 | 2026-02-24 |
| Prediction of Infectious Agents in the Biofire® FilmArray bioMérieux Meningitis/Encephalitis Panel Based on Clinical Syndrome and Cerebrospinal Fluid Parameters: a Diagnostic Stewardship Proposal. Biofire FilmArray Meningitis/Encephalitis Panel - Meningitis, Encephalitic Infection | Not applicable | Recruiting | Federal University of Health Science of Porto Alegre | 182 | 2026-04-13 | 2026-08-21 |
| Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 86 | 2026-04-01 | 2026-03-27 |
| Acute Treatment and Long-term Assessment of Adult Infectious Meningitis Viral Meningitis, Bacterial Meningitis | Recruiting | Hospital Israelita Albert Einstein | 624 | 2026-03-30 | 2026-08-13 | |
| Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis HRZE, HRZE plus Alpe375, HRZE plus AlpE500 - Tuberculosis Meningitis | Phase 2 | Not yet recruiting | BioVersys AG | 64 | 2026-03-30 | 2026-03-03 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 3-5 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 880 | 2026-03-25 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 12-23 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 6-11 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 2-6 Years experimental vaccine, active comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Active not recruiting | Sinovac Biotech Co., Ltd | 660 | 2026-03-22 | 2026-08-10 |
| Phase Ia Clinical Trial of Group ACYW135X Meningococcal Conjugate Vaccine high-dose Group ACYW135X Meningococcal Conjugate Vaccine, medium-dose Group ACYW135X Meningococcal Conjugate Vaccine, low-dose Group ACYW135X Meningococcal Conjugate Vaccine - Meningococcal Meningitis | Phase 1 | Not yet recruiting | Sinovac Life Sciences Co., Ltd. | 150 | 2026-01-21 | 2026-01-28 |
| Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis-Haemophilus influenzae type b (Conjugate)-Meningococcal Group ACYW135 (Conjugate) Combined Vaccine (DTcP-Hib-MCV4), DTcP-Hib-MCV4, Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis (DTcP) - Diphtheria, Tetanus and Acellular Pertussis, Epidemic Meningitis | Phase 1 | Recruiting | CanSino Biologics Inc. | 260 | 2025-12-19 | 2025-12-31 |
| Febrile Infants Swedish Study Febrile Illness Acute, Meningitis, Bacterial | Recruiting | Region Skane | 2000 | 2025-12-01 | 2026-04-02 |
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Meningitis, Meningococcal (125) · Meningitis (60) · Meningococcal Infections (60) · Meningitis, Bacterial (35) · Tuberculosis, Meningeal (30) · Lyme Neuroborreliosis (19) · Lyme Disease (11) · Tuberculosis (8) · Diphtheria (7) · Neurosyphilis (7) · Tetanus (7) · Whooping Cough (6) · Central Nervous System Infections (5) · Haemophilus Infections (5) · Meningitis, Pneumococcal (4)
Bacterial Infections and Mycoses (221) · Central Nervous System Diseases (220) · Infections (220) · Nervous System Diseases (220) · Bacterial Infections (218) · Central Nervous System Infections (216) · Neuroinflammatory Diseases (195) · Meningitis, Bacterial (158) · Gram-Negative Bacterial Infections (157) · Meningitis (134) · Neisseriaceae Infections (126) · Meningococcal Infections (66) · Gram-Positive Bacterial Infections (48) · Actinomycetales Infections (39)
Meningococcal Vaccines (31) · 4CMenB vaccine (10) · Ceftriaxone (7) · Doxycycline (7) · MenACWY-CRM vaccine (7) · Rifampin (7) · Linezolid (6) · Heptavalent Pneumococcal Conjugate Vaccine (5) · Aspirin (4) · Isoniazid (4) · Vaccines (4) · measles, mumps, rubella, varicella vaccine (4) · Chickenpox Vaccine (3) · Ciprofloxacin (3) · Dexamethasone (3)
Novartis Vaccines (27) · Sanofi Pasteur, a Sanofi Company (23) · Pfizer (10) · GlaxoSmithKline (9) · CanSino Biologics Inc. (8) · Novartis (7) · University Medical Centre Ljubljana (5) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (4) · Oxford University Clinical Research Unit, Vietnam (4) · Sinovac Biotech Co., Ltd (4) · Universitas Padjadjaran (4) · Wyeth is now a wholly owned subsidiary of Pfizer (4) · Assistance Publique - Hôpitaux de Paris (3) · Beijing Chest Hospital (3) · Epicentre (3)
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Alberto Yataco, MD (2) · Guy Thwaites, MD (2) · Lin Du (2) · Robert C Read (2) · Rovina Ruslami, M.D., PhD (2)
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