45 completed, 16 unknown, 5 recruiting, 3 not yet recruiting. 21 Not applicable, 15 Phase 3, 13 Phase 2, 7 Phase 4, 5 Phase 1.
Follow Cryptococcosis: new trials by email Literature Review of Cryptococcosis trials Research Report on Cryptococcosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Cryptococcosis Associated With Bruton Tyrosine Kinase Inhibitors Cryptococcosis | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-10-01 | 2026-10-19 | |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| Digital Rewards and Retention in a M-health App Multipurpose Online Tool, No intervention - Transdiagnostic Psychopathology, Attrition | Not applicable | Not yet recruiting | University of Bucharest | 177 | 2025-03-15 | 2025-03-19 |
| Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis AMBITION trial control, Flucytosine - Cryptococcal Meningitis | Phase 2 | Completed | University of Minnesota | 48 | 2024-04-09 | 2025-08-27 |
| Amphotericin B for Non-HIV Cryptococcal Meningitis Patients Amphotericin B 0.5 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks., Amphotericin B 0.7 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks. - Cryptococcal Meningitis, Antifungal Agents | Phase 4 | Unknown | Huashan Hospital | 250 | 2023-08-13 | 2023-12-21 |
| Prospective Observational Study on the Incidence of Opportunistic Fungal Infections Pneumocystis Jirovecii Infection, Pneumocystis | Completed | University of Colorado, Denver | 12032 | 2023-07-05 | 2025-04-02 | |
| Point of Care Tests to Identify Opportunistic Infections in Advanced HIV Patients in Mexico City Histoplasma Urine Antigen Lateral Flow Antigen test, Cryptococcal Lateral Flow Antigen test, Tuberculosis-lipoarabinomannan Lateral Flow Antigen test - Acquired Immunodeficiency Syndrome, Histoplasmosis AIDS | Not applicable | Unknown | National Institute of Respiratory Diseases, Mexico | 211 | 2023-04-01 | 2023-01-17 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 3 | Unknown | Matinas BioPharma Nanotechnologies, Inc. | 270 | 2023-01-01 | 2022-09-15 |
| Clinical Study of ABCD in the Treatment of Cryptococcal Meningitis Amphotericin B Colloidal Dispersion, flucytosine, fluconazole - Cryptococcal Meningitis | Not applicable | Unknown | Peking Union Medical College Hospital | 30 | 2022-08-22 | 2022-07-22 |
| Inpatient Package to Reduce HIV and AIDS-related Death in Zambia Inpatient lab bundling, Inpatient navigation - HIV/AIDS, Transitions of Care | Not applicable | Completed | University of Alabama at Birmingham | 72 | 2021-10-01 | 2024-08-09 |
| Comprehensive Diagnosis and Treatment Strategy for Opportunistic Fungal Infections in AIDS Patients examination methods - Opportunistic Fungal Infections | Unknown | Guangzhou 8th People's Hospital | 600 | 2021-04-01 | 2021-12-13 | |
| Three Induction Treatments on Cryptococcal Meningitis Voriconazole 200mg, amphotericin B deoxycholate (0.4-0.5mg/kg/d), Amphotericin B-deoxycholate (0.7-1.0mg/kg/d) - Cryptococcal Meningitis, HIV/AIDS | Early Phase 1 | Unknown | First Affiliated Hospital of Zhejiang University | 120 | 2021-01-25 | 2021-02-02 |
| Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis Amphotericin B 1 mg/kg 1 week & Flucytosine 100 mg/kg 1 week followed by Fluconazole 1200 mg/day 1 week - Cryptococcal Meningitis | Completed | University of Pharmacy, Yangon | 30 | 2020-10-01 | 2022-04-21 | |
| The Lived Experience of Participants in an African Randomised Trial In-depth interviews - HIV, Cryptococcal Meningitis | Completed | London School of Hygiene and Tropical Medicine | 89 | 2020-02-05 | 2022-04-06 | |
| AmB Dose for Cryptococcal Meningitis Amphotericin B, Flucytosine - Cryptococcal Meningitis, HIV Infections | Phase 3 | Unknown | Shanghai Public Health Clinical Center | 40 | 2020-01-02 | 2019-10-29 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 1 / Phase 2 | Completed | Matinas BioPharma Nanotechnologies, Inc. | 178 | 2019-10-24 | 2023-03-31 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
| Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART Centre CD4 cell count - HIV Infections, Tuberculosis | Completed | Singh, Ranjan Kumar, M.D. | 257 | 2019-06-01 | 2020-03-19 | |
| Derivation and Validation of a Scoring System to Distinguish Cryptococcosis and Adenocarcinoma in Pulmonary Nodules A scoring system - Cryptococcosis, Lung Adenocarcinoma | Unknown | Shanghai Pulmonary Hospital, Shanghai, China | 1000 | 2019-01-01 | 2020-09-18 |
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Meningitis, Cryptococcal (54) · Acquired Immunodeficiency Syndrome (28) · HIV Infections (26) · Meningitis (21) · AIDS-Related Opportunistic Infections (18) · Aspergillosis (7) · Candidiasis (7) · Mycoses (6) · Opportunistic Infections (3) · Tuberculosis (3) · Brain Diseases (2) · Invasive Fungal Infections (2) · Meningitis, Bacterial (2) · Meningitis, Fungal (2)
Bacterial Infections and Mycoses (73) · Infections (73) · Mycoses (67) · Central Nervous System Diseases (54) · Neuroinflammatory Diseases (54) · Central Nervous System Fungal Infections (53) · Central Nervous System Infections (53) · Nervous System Diseases (53) · Meningitis, Fungal (52) · Immune System Diseases (39) · Virus Diseases (39) · Blood-Borne Infections (38) · Communicable Diseases (38) · Immunologic Deficiency Syndromes (38) · Lentivirus Infections (38)
Fluconazole (28) · Amphotericin B (23) · Flucytosine (13) · liposomal amphotericin B (4) · Voriconazole (3) · amphotericin B, deoxycholate drug combination (3) · Antiretroviral Therapy, Highly Active (2) · Itraconazole (2) · Lamivudine (2) · Sertraline (2) · Stavudine (2) · efungumab (2) · CD4 Lymphocyte Count (1) · Dexamethasone (1) · Injections (1)
Pfizer (12) · National Institute of Allergy and Infectious Diseases (NIAID) (8) · University of Minnesota (6) · Merck Sharp & Dohme LLC (3) · National Hospital for Tropical Diseases, Hanoi, Vietnam (3) · ANRS, Emerging Infectious Diseases (2) · Matinas BioPharma Nanotechnologies, Inc. (2) · Novartis Pharmaceuticals (2) · University of Zimbabwe (2) · Alkermes, Inc. (1) · Asahi Kasei Therapeutics Corporation (1) · Assistance Publique - Hôpitaux de Paris (1) · Botswana-UPenn Partnership (1) · David Boulware (1) · First Affiliated Hospital of Zhejiang University (1)
United States (26) · Uganda (11) · China (6) · Vietnam (4) · Zimbabwe (4) · Canada (3) · India (3) · South Africa (3) · Thailand (3) · Botswana (2) · Cameroon (2) · Japan (2) · Peru (2) · Taiwan (2) · Burma (1)
Radha Rajasingham, MD (3) · Armstrong D (2) · David R Boulware, MD, MPH (2) · Angela Loyse, MD (1) · Azure T Makadzange, MD DPhil (1) · Azure T Makadzange, MD, DPhil (1) · Baosong Xie (1) · Charles Kouanfack, MD, PhD (1) · Chengping Hu (1) · Chiratidzo E Ndhlovu, MBBS, MSc (1) · Chiratidzo E Ndhlovu, MBChB, FRCP (1) · David B Meya (1)
PMID 39972326, PMID 30325463, PMID 32843994, PMID 16436724, PMID 18813103, PMID 19441980, PMID 19485785, PMID 19897055, PMID 20415574, PMID 22153000, PMID 22487689, PMID 22611389, PMID 22701801, PMID 22966426, PMID 23316226, PMID 23362285, PMID 23485767, PMID 23802091, PMID 23935613, PMID 23997952, PMID 24028937, PMID 24052877, PMID 24069604, PMID 24163804, PMID 24175292, PMID 24275116, PMID 24288689, PMID 24348184, PMID 24470926, PMID 24470936, PMID 24639956, PMID 24688879, PMID 24963568, PMID 25002959, PMID 25013814, PMID 25170450, PMID 25232730, PMID 25499123, PMID 26347376, PMID 26448766, PMID 26768369, PMID 27231666, PMID 27330070, PMID 27433510, PMID 30256903, PMID 30345376, PMID 30399034, PMID 30801037, PMID 31242860, PMID 31319498
R01NS086312 (1), U01AI089244 (1), U01AI125003 (1), U01GH000517 (1)