71 completed, 7 recruiting, 6 unknown, 5 terminated. 96 Phase 2, 13 Phase 3, 11 Phase 1.
Follow Meningitis: new trials by email Literature Review of Meningitis trials Research Report on Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia | Phase 2 | Not yet recruiting | Milton S. Hershey Medical Center | 240 | 2026-12-01 | 2026-10-09 |
| A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial GBS-NN/NN2 vaccine, Placebo - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Not yet recruiting | Minervax ApS | 6600 | 2026-11-30 | 2026-11-06 |
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT) - Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP) | Phase 2 | Not yet recruiting | BioVersys AG | 120 | 2026-07-01 | 2026-02-24 |
| Olorofim in Early Coccidioidal Meningitis olorofim - Coccidioidal Meningitis | Phase 2 | Recruiting | Fariba Donovan | 12 | 2026-06-01 | 2026-07-27 |
| Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis HRZE, HRZE plus Alpe375, HRZE plus AlpE500 - Tuberculosis Meningitis | Phase 2 | Not yet recruiting | BioVersys AG | 64 | 2026-03-30 | 2026-03-03 |
| Adjunctive Doxycycline for Central Nervous System Tuberculosis Doxycycline, Placebo, Anti Tuberculosis Drug - Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology) | Phase 2 | Recruiting | National University Hospital, Singapore | 200 | 2025-08-21 | 2026-06-01 |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| A Follow-up Trial of GBS-NN/NN2 Vaccine in Healthy Pregnant Women GBS-NN/NN2 vaccine - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Active not recruiting | Minervax ApS | 137 | 2025-03-07 | 2026-09-04 |
| Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis AMBITION trial control, Flucytosine - Cryptococcal Meningitis | Phase 2 | Completed | University of Minnesota | 48 | 2024-04-09 | 2025-08-27 |
| A Study of the ACYW135 Meningococcal Polysaccharide Conjugate Vaccine ACYW135 Meningococcal Polysaccharide Conjugate Vaccine, ACYW135 Meningococcal Polysaccharide Vaccine - Meningococcal Meningitis | Phase 2 | Unknown | Aimei Vacin BioPharm (Zhejiang) Co., Ltd. | 1200 | 2024-03-20 | 2024-03-29 |
| Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis Contezolid, Linezolid (LZD) - Tuberculosis, Meningitis | Phase 1 / Phase 2 | Enrolling by invitation | Beijing Chest Hospital | 24 | 2024-02-01 | 2025-02-06 |
| Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD) - Tuberculous Meningitis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 330 | 2023-12-07 | 2026-06-02 |
| Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis Adalimumab Injection - Tuberculous Meningitis, HIV I Infection | Phase 2 | Recruiting | ANRS, Emerging Infectious Diseases | 130 | 2023-04-11 | 2025-12-15 |
| Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents MenABCWY vaccine, Placebo - Meningitis, Meningococcal | Phase 2 | Active not recruiting | GlaxoSmithKline | 305 | 2021-11-18 | 2026-09-28 |
| Pharmacokinetic Study of Linezolid for TB Meningitis Linezolid - Tuberculosis, Meningeal, Linezolid | Phase 2 | Completed | Universitas Padjadjaran | 36 | 2021-06-21 | 2023-09-06 |
| Adjunctive Linezolid for the Treatment of Tuberculous Meningitis LZD, High dose RIF, Standard dose RIF - Tuberculosis, Meningeal | Phase 2 | Completed | University of California, San Francisco | 40 | 2021-05-05 | 2024-10-01 |
| Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis Cyclophosphamide injection - Tuberculosis, Tubercular Meningitis | Phase 2 / Phase 3 | Unknown | All India Institute of Medical Sciences | 40 | 2021-01-01 | 2020-12-30 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 1 / Phase 2 | Completed | Matinas BioPharma Nanotechnologies, Inc. | 178 | 2019-10-24 | 2023-03-31 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
Showing 20 of 96. Sign in to see all of them.
Meningitis, Meningococcal (35) · Meningococcal Infections (31) · Tuberculosis, Meningeal (15) · Meningitis, Cryptococcal (12) · HIV Infections (6) · Tuberculosis (5) · Acquired Immunodeficiency Syndrome (3) · Pneumonia (3) · Arachnoiditis (2) · Bacterial Infections (2) · Central Nervous System Infections (2) · Cryptococcosis (2) · Encephalitis (2) · Latent Tuberculosis (2)
Nervous System Diseases (96) · Neuroinflammatory Diseases (96) · Infections (86) · Bacterial Infections and Mycoses (81) · Bacterial Infections (68) · Central Nervous System Diseases (68) · Central Nervous System Infections (65) · Central Nervous System Bacterial Infections (52) · Meningitis, Bacterial (51) · Gram-Negative Bacterial Infections (49) · Neisseriaceae Infections (48) · Gram-Positive Bacterial Infections (18) · Meningococcal Infections (17) · Actinomycetales Infections (16)
Meningococcal Vaccines (22) · Amphotericin B (8) · Fluconazole (7) · Rifampin (6) · Flucytosine (5) · Linezolid (5) · 4CMenB vaccine (4) · Vaccines (4) · Heptavalent Pneumococcal Conjugate Vaccine (3) · Aspirin (2) · Ceftazidime (2) · Dexamethasone (2) · Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate (2) · Hiberix (2) · Isoniazid (2)
Sanofi Pasteur, a Sanofi Company (16) · Novartis Vaccines (9) · GlaxoSmithKline (6) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Pfizer (4) · Universitas Padjadjaran (4) · ANRS, Emerging Infectious Diseases (2) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (2) · BioVersys AG (2) · David Boulware (2) · Minervax ApS (2) · Novartis Pharmaceuticals (2) · Oxford University Clinical Research Unit, Vietnam (2) · Sanofi (2) · Wyeth is now a wholly owned subsidiary of Pfizer (2)
United States (32) · Uganda (7) · Poland (6) · South Africa (6) · United Kingdom (6) · Finland (5) · Germany (5) · Indonesia (5) · Vietnam (5) · Australia (4) · Brazil (4) · Chile (4) · China (4) · Spain (4) · Belgium (3)
Rovina Ruslami, M.D., PhD (2) · Abraham Aseffa Aseffa, M.D, PhD (1) · Ahmad R Ganiem, MD, PhD (1) · Ahmed Bedru Omer, M.D,Pediatrician (1) · Alberto Yataco, MD (1) · Angharad G Davis, Dr (1) · Anthony H Guarino, MD (1) · Arezou Khosroshahi, MD (1)
PMID 35164991, PMID 32681472, PMID 36369456, PMID 16203934, PMID 16417952, PMID 17072120, PMID 17548138, PMID 19150378, PMID 19441980, PMID 19776196, PMID 19897055, PMID 20431379, PMID 21177912, PMID 21645573, PMID 21987006, PMID 22569484, PMID 22622049, PMID 23103177, PMID 23114372, PMID 23352429, PMID 23451070, PMID 23595505, PMID 25077420, PMID 25424810, PMID 25667206, PMID 25703312, PMID 25969894, PMID 26075813, PMID 26135245, PMID 26756390, PMID 26803328, PMID 27642132, PMID 27745812, PMID 28069358, PMID 28296863, PMID 28403842, PMID 28580433, PMID 28702291, PMID 29028802, PMID 29482717, PMID 30224533, PMID 30801037, PMID 31518978, PMID 32209248, PMID 32233959, PMID 32233961, PMID 32747357, PMID 33020485, PMID 33767093, PMID 33972248
2017 (3), 2008 (2), 2009 (2), 2014 (1), 2016 (1), R01HD074944 (1), R01HD122957 (1), R21TW011035 (1), U01HD019897 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD021415 (1)