16 completed, 6 unknown, 5 recruiting, 2 not yet recruiting. 15 Phase 2, 6 Phase 3, 4 Not applicable, 2 Phase 1, 1 Phase 4.
Follow Tuberculosis, Meningeal: new trials by email Literature Review of Tuberculosis, Meningeal trials Research Report on Tuberculosis, Meningeal
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BPaLMZ for TB Meningitis BPaLMZ Regimen - Tuberculous Meningitis, HIV | Phase 2 | Recruiting | David Boulware | 312 | 2026-07-28 | 2026-10-16 |
| Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis HRZE, HRZE plus Alpe375, HRZE plus AlpE500 - Tuberculosis Meningitis | Phase 2 | Not yet recruiting | BioVersys AG | 64 | 2026-03-30 | 2026-03-03 |
| Adjunctive Doxycycline for Central Nervous System Tuberculosis Doxycycline, Placebo, Anti Tuberculosis Drug - Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology) | Phase 2 | Recruiting | National University Hospital, Singapore | 200 | 2025-08-21 | 2026-06-01 |
| Intensified Short Course Regimen for TBM in Adults High dose rifampicin (25mg/kg), Moxifloxacin 400mg, Aspirin 150 mg - Tuberculous Meningitis | Phase 3 | Not yet recruiting | Indian Council of Medical Research | 372 | 2024-03-01 | 2023-12-21 |
| Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis Contezolid, Linezolid (LZD) - Tuberculosis, Meningitis | Phase 1 / Phase 2 | Enrolling by invitation | Beijing Chest Hospital | 24 | 2024-02-01 | 2025-02-06 |
| Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD) - Tuberculous Meningitis | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 330 | 2023-12-07 | 2026-06-02 |
| Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis Adalimumab Injection - Tuberculous Meningitis, HIV I Infection | Phase 2 | Recruiting | ANRS, Emerging Infectious Diseases | 130 | 2023-04-11 | 2025-12-15 |
| Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes MRI Brain and spine, Reference standard diagnostic criteria - Tuberculous Meningitis, Tuberculous Arachnoiditis | Unknown | All India Institute of Medical Sciences | 120 | 2022-01-27 | 2022-12-05 | |
| Pharmacokinetic Study of Linezolid for TB Meningitis Linezolid - Tuberculosis, Meningeal, Linezolid | Phase 2 | Completed | Universitas Padjadjaran | 36 | 2021-06-21 | 2023-09-06 |
| Adjunctive Linezolid for the Treatment of Tuberculous Meningitis LZD, High dose RIF, Standard dose RIF - Tuberculosis, Meningeal | Phase 2 | Completed | University of California, San Francisco | 40 | 2021-05-05 | 2024-10-01 |
| Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis Aspirin, Placebo of aspirin, WHO TBM treatment - Tuberculous Meningitis | Phase 3 | Recruiting | ANRS, Emerging Infectious Diseases | 768 | 2021-02-07 | 2026-06-24 |
| Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis Cyclophosphamide injection - Tuberculosis, Tubercular Meningitis | Phase 2 / Phase 3 | Unknown | All India Institute of Medical Sciences | 40 | 2021-01-01 | 2020-12-30 |
| Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis Tuberculous Meningitis | Completed | University of Stellenbosch | 332 | 2020-04-01 | 2025-12-16 | |
| Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM Linezolid, High dose rifampicin, Aspirin - Tuberculosis Meningitis, HIV-1-infection | Phase 2 | Completed | University of Cape Town | 52 | 2019-06-12 | 2021-09-28 |
| Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Isoniazid - Tuberculous Meningitis | Not applicable | Unknown | Beijing Chest Hospital | 676 | 2019-03-04 | 2021-02-01 |
| Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Dexamethasone, Placebo - Tuberculosis, Tuberculous Meningitis | Phase 3 | Completed | Oxford University Clinical Research Unit, Vietnam | 702 | 2018-02-12 | 2025-06-17 |
| Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Linezolid - Tuberculous Meningitis | Unknown | Huashan Hospital | 150 | 2018-01-01 | 2019-04-02 | |
| Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Dexamethasone, Placebo - Tuberculosis, Tuberculous Meningitis | Phase 3 | Completed | Oxford University Clinical Research Unit, Vietnam | 520 | 2017-05-25 | 2024-03-22 |
| Optimizing Treatment to Improve TBM Outcomes in Children High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB - Tuberculosis, Meningeal | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 38 | 2017-02-22 | 2021-10-28 |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
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Tuberculosis (8) · Meningitis (4) · Chemical and Drug Induced Liver Injury (2) · Latent Tuberculosis (2) · AIDS-Related Opportunistic Infections (1) · Acquired Immunodeficiency Syndrome (1) · Arachnoiditis (1) · Central Nervous System Diseases (1) · Disease (1) · HIV Infections (1) · Meningitis, Bacterial (1) · Meningitis, Cryptococcal (1) · Meningoencephalitis (1) · Toxoplasmosis, Cerebral (1)
Actinomycetales Infections (30) · Bacterial Infections (30) · Bacterial Infections and Mycoses (30) · Central Nervous System Bacterial Infections (30) · Central Nervous System Infections (30) · Gram-Positive Bacterial Infections (30) · Infections (30) · Mycobacterium Infections (30) · Nervous System Diseases (30) · Neuroinflammatory Diseases (30) · Tuberculosis, Extrapulmonary (30) · Central Nervous System Diseases (29) · Meningitis, Bacterial (29) · Tuberculosis, Central Nervous System (29) · Meningitis (26)
Rifampin (7) · Linezolid (6) · Aspirin (4) · Isoniazid (4) · Dexamethasone (3) · Moxifloxacin (2) · Pyrazinamide (2) · Adalimumab (1) · Antitubercular Agents (1) · Control Groups (1) · Cyclophosphamide (1) · Doxycycline (1) · Ethambutol (1) · Levofloxacin (1) · NSC 366140 (1)
Oxford University Clinical Research Unit, Vietnam (4) · Universitas Padjadjaran (4) · Beijing Chest Hospital (3) · ANRS, Emerging Infectious Diseases (2) · All India Institute of Medical Sciences (2) · BioVersys AG (1) · Chiang Mai University (1) · David Boulware (1) · Huashan Hospital (1) · Hui Bu (1) · Indian Council of Medical Research (1) · Johns Hopkins University (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National University Hospital, Singapore (1) · St George's, University of London (1)
Indonesia (6) · Vietnam (5) · China (4) · India (4) · South Africa (4) · Malawi (3) · Uganda (3) · Brazil (2) · Tanzania (2) · Cameroon (1) · Côte d’Ivoire (1) · Kenya (1) · Madagascar (1) · Malaysia (1) · Mexico (1)
Guy Thwaites, MD (2) · Rovina Ruslami, M.D., PhD (2) · Ahmad R Ganiem, MD, PhD (1) · Angela Loyse, MD (1) · Angharad G Davis, Dr (1) · David Boulware, MD (1) · Estee Torok (1) · Estee Torok, MD (1) · Fabrice Bonnet, M.D., Ph.D. (1) · Felicia C Chow, MD (1) · Gang Zhao, Dr. (1) · Graeme Meintjes, PhD (1) · Guy Thwaites, MD, PhD (1) · Hongfei Duan, MD (1)
PMID 33283229, PMID 22174748, PMID 23103177, PMID 25703312, PMID 29482717, PMID 30224533, PMID 33972248, PMID 34286103, PMID 35291004, PMID 35506251, PMID 35767219, PMID 36348453, PMID 36482216, PMID 37740554, PMID 37802567, PMID 37819954, PMID 38693583, PMID 41540106
R01HD074944 (1), R21TW011035 (1)