95 completed, 9 unknown, 6 recruiting, 3 active not recruiting. 116 Phase 3, 13 Phase 2.
Follow Meningitis: new trials by email Literature Review of Meningitis trials Research Report on Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial GBS-NN/NN2 vaccine, Placebo - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Not yet recruiting | Minervax ApS | 6600 | 2026-11-30 | 2026-11-06 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 3-5 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 880 | 2026-03-25 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 12-23 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 6-11 Months experimental vaccine, Active Comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Recruiting | Sinovac Biotech Co., Ltd | 1040 | 2026-03-22 | 2026-08-10 |
| Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged 2-6 Years experimental vaccine, active comparator vaccine - Epidemic Meningitis, Meningococcal Vaccines | Phase 3 | Active not recruiting | Sinovac Biotech Co., Ltd | 660 | 2026-03-22 | 2026-08-10 |
| A Phase 3 Study to Assess the Immune Response and Safety of rMenB+OMV NZ in Primed Healthy Participants (10 to 20 Years Old) rMenB+OMV NZ vaccine - Meningitis | Phase 3 | Completed | GlaxoSmithKline | 312 | 2025-07-07 | 2026-11-06 |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| A Follow-up Trial of GBS-NN/NN2 Vaccine in Healthy Pregnant Women GBS-NN/NN2 vaccine - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Active not recruiting | Minervax ApS | 137 | 2025-03-07 | 2026-09-04 |
| A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 7 to 17 Year Olds MCV4, MPSV4 - Meningococcal Meningitis | Phase 3 | Completed | CanSino Biologics Inc. | 840 | 2024-12-14 | 2026-08-06 |
| A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years batch 1 of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) (MCV4), batch 2 of MCV4, batch 3 of MCV4 - Meningococcal Meningitis | Phase 3 | Completed | CanSino Biologics Inc. | 1480 | 2024-03-20 | 2026-08-06 |
| A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 18-59 Year Olds MCV4, MPSV4 - Meningococcal Meningitis | Phase 3 | Active not recruiting | CanSino Biologics Inc. | 840 | 2024-03-01 | 2025-07-29 |
| Intensified Short Course Regimen for TBM in Adults High dose rifampicin (25mg/kg), Moxifloxacin 400mg, Aspirin 150 mg - Tuberculous Meningitis | Phase 3 | Not yet recruiting | Indian Council of Medical Research | 372 | 2024-03-01 | 2023-12-21 |
| A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in a 4 to 6 Year-old Population MCV4, MSPV4 - Epidemic Meningitis | Phase 3 | Completed | CanSino Biologics Inc. | 1000 | 2023-09-16 | 2025-07-03 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 3 | Unknown | Matinas BioPharma Nanotechnologies, Inc. | 270 | 2023-01-01 | 2022-09-15 |
| Meningococcal Serogroup ACYWX Conjugate Vaccine in Comparison With MenACWY-TT Conjugate Vaccine NmCV-5, MenACWY-TT - Meningitis | Phase 3 | Completed | Emory University | 1325 | 2022-03-24 | 2026-03-31 |
| Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Volunteers Aged From 3 to 5 Months Meningococcal ACYW135 Polysaccharide Conjugate Vaccine, Meningococcal A and C Polysaccharide Conjugate Vaccine - Meningitis, Meningococcal | Phase 3 | Unknown | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 1200 | 2021-12-18 | 2024-04-04 |
| Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis Aspirin, Placebo of aspirin, WHO TBM treatment - Tuberculous Meningitis | Phase 3 | Recruiting | ANRS, Emerging Infectious Diseases | 768 | 2021-02-07 | 2026-06-24 |
| Immunogenicity and Safety Study of GSK's MenABCWY Vaccine in Healthy Adolescents and Adults Previously Primed With MenACWY Vaccine MenABCWY vaccine, Placebo, MenACWY vaccine - Meningitis, Meningococcal | Phase 3 | Completed | GlaxoSmithKline | 1250 | 2021-01-25 | 2024-07-03 |
| Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis Cyclophosphamide injection - Tuberculosis, Tubercular Meningitis | Phase 2 / Phase 3 | Unknown | All India Institute of Medical Sciences | 40 | 2021-01-01 | 2020-12-30 |
Showing 20 of 116. Sign in to see all of them.
Meningitis, Meningococcal (54) · Meningococcal Infections (47) · Meningitis, Cryptococcal (9) · Pneumonia (9) · Meningitis, Bacterial (8) · Haemophilus Infections (6) · Sepsis (6) · Tetanus (6) · Tuberculosis, Meningeal (6) · Whooping Cough (6) · Chickenpox (4) · Diphtheria (4) · Measles (4) · Mumps (4)
Neuroinflammatory Diseases (116) · Nervous System Diseases (113) · Infections (108) · Bacterial Infections and Mycoses (100) · Bacterial Infections (92) · Gram-Negative Bacterial Infections (80) · Central Nervous System Diseases (77) · Central Nervous System Infections (76) · Neisseriaceae Infections (73) · Central Nervous System Bacterial Infections (68) · Meningitis, Bacterial (60) · Meningococcal Infections (26) · Gram-Positive Bacterial Infections (16) · Respiratory Tract Diseases (16)
Meningococcal Vaccines (24) · 4CMenB vaccine (8) · MenACWY-CRM vaccine (8) · measles, mumps, rubella, varicella vaccine (5) · 13-valent pneumococcal vaccine (4) · Amphotericin B (4) · Chickenpox Vaccine (4) · Fluconazole (4) · Hepatitis A Vaccines (4) · Heptavalent Pneumococcal Conjugate Vaccine (4) · HibTITER protein, Haemophilus influenzae (4) · PHiD-CV vaccine (4) · Vaccines (4) · Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate (3) · Hepatitis B Vaccines (3)
Novartis Vaccines (25) · Sanofi Pasteur, a Sanofi Company (18) · GlaxoSmithKline (12) · Novartis (7) · CanSino Biologics Inc. (4) · Pfizer (4) · Sinovac Biotech Co., Ltd (4) · ANRS, Emerging Infectious Diseases (2) · Beijing Minhai Biotechnology Co., Ltd (2) · Merck Sharp & Dohme LLC (2) · Minervax ApS (2) · Oxford University Clinical Research Unit, Vietnam (2) · University of Minnesota (2) · University of Oxford (2) · All India Institute of Medical Sciences (1)
United States (26) · China (17) · Germany (10) · Italy (9) · Spain (9) · Canada (7) · Czechia (7) · Finland (7) · Puerto Rico (7) · United Kingdom (7) · Argentina (5) · Australia (5) · India (5) · Uganda (5) · Chile (4)
Guy Thwaites, MD (2) · Andrew J Pollard, FRCPCH, PhD (1) · Andrew Pollard, FRCPCH, PhD (1) · Armstrong D (1) · Avroy A. Fanaroff, MD (1) · Charles R. Bauer, MD (1) · Christian L Coles, PhD (1)
PMID 29253560, PMID 33283229, PMID 33325757, PMID 19476428, PMID 19812260, PMID 19895922, PMID 20164251, PMID 20189491, PMID 20439595, PMID 20655261, PMID 20943209, PMID 21339701, PMID 21389149, PMID 21817954, PMID 22094635, PMID 22855388, PMID 23324563, PMID 24873986, PMID 25075804, PMID 25285126, PMID 25308927, PMID 25483566, PMID 25977146, PMID 26075813, PMID 26232542, PMID 26479973, PMID 26756390, PMID 26826544, PMID 28318767, PMID 28580917, PMID 29038320, PMID 29277353, PMID 29299402, PMID 29789243, PMID 30068713, PMID 30184183, PMID 30224533, PMID 30256903, PMID 30325463, PMID 30345376, PMID 30691980, PMID 31110098, PMID 31242860, PMID 31279564, PMID 31327652, PMID 31345462, PMID 31518978, PMID 32209015, PMID 32307307, PMID 32387012
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