23 completed, 3 terminated, 3 unknown, 1 active not recruiting. 33 Phase 1, 11 Phase 2.
Follow Meningitis: new trials by email Literature Review of Meningitis trials Research Report on Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase Ia Clinical Trial of Group ACYW135X Meningococcal Conjugate Vaccine high-dose Group ACYW135X Meningococcal Conjugate Vaccine, medium-dose Group ACYW135X Meningococcal Conjugate Vaccine, low-dose Group ACYW135X Meningococcal Conjugate Vaccine - Meningococcal Meningitis | Phase 1 | Not yet recruiting | Sinovac Life Sciences Co., Ltd. | 150 | 2026-01-21 | 2026-01-28 |
| Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis-Haemophilus influenzae type b (Conjugate)-Meningococcal Group ACYW135 (Conjugate) Combined Vaccine (DTcP-Hib-MCV4), DTcP-Hib-MCV4, Adsorbed Acellular Pertussis (3-Component) Diphtheria-Tetanus-Pertussis (DTcP) - Diphtheria, Tetanus and Acellular Pertussis, Epidemic Meningitis | Phase 1 | Recruiting | CanSino Biologics Inc. | 260 | 2025-12-19 | 2025-12-31 |
| A Study to Evaluate Safety and Immunogenicity of Haemophilus Influenzae Serotype A Vaccine Haemophilus influenzae type a (Hia) glycoconjugate vaccine - Haemophilus Influenzae Meningitis, Invasive Haemophilus Influenzae Disease | Phase 1 | Active not recruiting | InventVacc Biologicals Inc. | 30 | 2024-05-29 | 2025-04-30 |
| Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis Contezolid, Linezolid (LZD) - Tuberculosis, Meningitis | Phase 1 / Phase 2 | Enrolling by invitation | Beijing Chest Hospital | 24 | 2024-02-01 | 2025-02-06 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 1 / Phase 2 | Completed | Matinas BioPharma Nanotechnologies, Inc. | 178 | 2019-10-24 | 2023-03-31 |
| Safety Evaluation of Meningococcal Group ACYW135 Conjugate Vaccine in 2-month to 55 Years Old Population. Meningococcal Group ACYW135 Conjugate Vaccine - Meningococcal Infections | Phase 1 | Completed | Walvax Biotechnology Co., Ltd. | 100 | 2018-07-17 | 2020-01-22 |
| Optimizing Treatment to Improve TBM Outcomes in Children High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB - Tuberculosis, Meningeal | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 38 | 2017-02-22 | 2021-10-28 |
| Immunogenicity and Safety of Meningococcal Groups A and C and Haemophilus b Conjugate Vaccine in Infants 2 to 5 Months of Age Meningococcal Groups A and C and Haemophilus b Conjugate Vaccine (adjuvant-free), Meningococcal Groups A and C and Haemophilus b Conjugate Vaccine(adjuvant) - Meningitis, Meningococcal Meningitis | Phase 1 / Phase 2 | Unknown | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 360 | 2016-08-01 | 2016-09-29 |
| Safety Study of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months Meningococcal ACYW135 Polysaccharide Conjugate Vaccine - Meningitis, Meningococcal | Phase 1 | Unknown | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 200 | 2016-06-01 | 2016-08-26 |
| Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report Vietnam Cryptococcal Retention in Care Study (CRICS) - Cryptococcal Meningitis | Phase 1 | Completed | National Hospital for Tropical Diseases, Hanoi, Vietnam | 1177 | 2015-06-01 | 2018-03-29 |
| A Single-center, Open Trials to Evaluate the Safety of Freeze-dried Group ACYW135 Meningococcal Conjugate Vaccine freeze-dried group ACYW135 MCV - Meningococcal Meningitis | Phase 1 | Unknown | Lanzhou Institute of Biological Products Co., Ltd | 200 | 2015-06-01 | 2015-06-25 |
| Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF) Ceftaroline fosamil - Meningitis, Ventriculitis | Phase 1 | Completed | Centre Hospitalier Universitaire Dijon | 10 | 2015-04-29 | 2024-02-21 |
| Stem Cell Transplantation In-patient With Neurological Sequelae Due to Encephalitis or Meningitis Stem cell transplantation - Encephalitis, Meningitis | Phase 1 / Phase 2 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 22 | 2014-06-16 | 2024-06-06 |
| Safety and Immunogenicity Study in Young Adults the Meningococcal Serogroup C Vaccine Produced by Bio-Manguinhos 'MenCC-Bio', MENJUGATE - Meningitis, Meningococcal, Serogroup C | Phase 1 | Completed | The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz) | 60 | 2014-05-01 | 2015-09-16 |
| Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days of Age With Probable and Confirmed Meningitis Meropenem - Meningitis | Phase 1 / Phase 2 | Completed | PENTA Foundation | 51 | 2013-02-01 | 2015-02-16 |
| Rituximab in IgG4-RD: A Phase 1-2 Trial Rituximab - Retroperitoneal Fibrosis, Autoimmune Pancreatitis | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 30 | 2012-04-01 | 2017-07-02 |
| Daptomycin in Pediatric Patients With Bacterial Meningitis Daptomycin - Meningitis | Phase 1 | Terminated | Insel Gruppe AG, University Hospital Bern | 1 | 2012-04-01 | 2018-10-11 |
| A Study of Doripenem in CerebrospinalFluid After Doripenem Administration in Pediatric Patients Less Than 1 Year of Age Doripenem - Meningitis | Phase 1 | Terminated | Janssen Research & Development, LLC | 1 | 2012-03-01 | 2013-12-06 |
| Safety Study of Group A, C, Y & W-135 Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine for Meningitis meningococcal meningitis conjugate vaccine, quadrivalent - Meningococcal Meningitis, Meningococcal Infections | Phase 1 | Completed | JN-International Medical Corporation | 60 | 2011-11-01 | 2013-01-14 |
| High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Fluconazole, Amphotericin B - Cryptococcal Meningitis, HIV Infections | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 168 | 2010-04-16 | 2021-11-04 |
Showing 20 of 33. Sign in to see all of them.
Meningitis, Meningococcal (13) · Meningitis, Cryptococcal (5) · Meningococcal Infections (5) · HIV Infections (4) · Acquired Immunodeficiency Syndrome (3) · AIDS-Related Opportunistic Infections (2) · Central Nervous System Infections (2) · Meningeal Carcinomatosis (2) · Tuberculosis, Meningeal (2) · Autoimmune Pancreatitis (1) · Cryptococcosis (1) · Diphtheria (1) · Encephalitis (1) · Haemophilus Infections (1)
Nervous System Diseases (33) · Neuroinflammatory Diseases (33) · Infections (24) · Central Nervous System Diseases (23) · Bacterial Infections and Mycoses (21) · Central Nervous System Infections (20) · Bacterial Infections (16) · Central Nervous System Bacterial Infections (15) · Meningitis, Bacterial (15) · Gram-Negative Bacterial Infections (14) · Neisseriaceae Infections (14) · Meningococcal Infections (9) · Immune System Diseases (7) · Urogenital Diseases (6)
Amphotericin B (3) · Blood Specimen Collection (1) · CRM197 (non-toxic variant of diphtheria toxin) (1) · Ceftaroline (1) · Control Groups (1) · Daptomycin (1) · Doripenem (1) · Fluconazole (1) · Gemcitabine (1) · HibTITER protein, Haemophilus influenzae (1) · Isoniazid (1) · Levofloxacin (1) · Linezolid (1) · Meningococcal Vaccines (1) · Meropenem (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · Baylor College of Medicine (2) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (2) · Sanofi Pasteur, a Sanofi Company (2) · Wyeth is now a wholly owned subsidiary of Pfizer (2) · Alkermes, Inc. (1) · Beijing Chest Hospital (1) · CanSino Biologics Inc. (1) · Centre Hospitalier Universitaire Dijon (1) · Gilead Sciences (1) · Hualan Biological Engineering, Inc. (1) · Insel Gruppe AG, University Hospital Bern (1) · InventVacc Biologicals Inc. (1) · JN-International Medical Corporation (1) · Janssen Research & Development, LLC (1)
United States (11) · China (6) · Australia (3) · India (2) · Uganda (2) · Vietnam (2) · Belgium (1) · Brazil (1) · Canada (1) · France (1) · Kenya (1) · Malawi (1) · Peru (1) · Puerto Rico (1) · South Africa (1)
Susan Blaney, MD (2) · Arezou Khosroshahi, MD (1) · Barnett Gibbs, MD (1) · Brian Ward, MD (1) · Fubao Ma, Bachelor (1) · George K. Siberry, MD, MPH (1) · Joanne Langley, MD (1) · John H Stone, MD, MPH (1) · Jorge Lujan-Zilbermann, MD, MS (1) · Kelly Dooley, MD,PhD (1)
PMID 35164991, PMID 17909804, PMID 20431379, PMID 21910214, PMID 21987006, PMID 22094636, PMID 22622049, PMID 22832260, PMID 23352429, PMID 23595505, PMID 25667206, PMID 28296863, PMID 28403842, PMID 30535190, PMID 32747357, PMID 34446679, PMID 35291004, PMID 36780493, PMID 37606364, PMID 38943665, PMID 39972326, PMID 40665233
R01HD074944 (1)