36 completed, 18 recruiting, 8 terminated, 8 unknown. 28 Not applicable, 12 Phase 2, 8 Phase 3, 7 Phase 1, 5 Phase 4.
Follow Major Depressive Episode: new trials by email Literature Review of Major Depressive Episode trials Research Report on Major Depressive Episode
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive Episodes Oral ketamine, Oral midazolam - Major Depressive Episode | Phase 3 | Not yet recruiting | Jawaharlal Institute of Postgraduate Medical Education & Research | 220 | 2026-10-01 | 2026-10-01 |
| Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE) Light therapy - Major Depressive Episode | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 173 | 2026-06-17 | 2026-08-12 |
| tDCS: Sleep to Mood in Depression (S2M-D) transcranial direct current stimulation (tDCS) - Major Depressive Disorder, MDD | Not applicable | Recruiting | NYU Langone Health | 35 | 2026-06-04 | 2026-06-08 |
| Remote Medical Monitoring of Patients With Depression Use of ThIA Medical Device - Depression Chronic, Depression and Quality of Life | Phase 1 | Recruiting | ThIA Santé Mentale | 608 | 2026-04-01 | 2026-10-16 |
| EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2026-01-01 | 2026-08-05 | |
| EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2025-12-01 | 2026-07-31 | |
| Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD) 60Hz Intermittent Light Therapy, Sham Light Therapy - Depression, MDD | Not applicable | Recruiting | NYU Langone Health | 40 | 2025-08-18 | 2026-06-29 |
| Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents MagPro X100 edition (MagVenture, Skovlunde, Denmark) - Major Depressive Disorder, Depression in Adolescence | Not applicable | Recruiting | University of Texas at Austin | 40 | 2025-04-01 | 2026-08-19 |
| Personalized Ultrasonic Brain Stimulation for Depression (R61) LTFUS to SCC, LTFUS to ALIC - Major Depressive Episode, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Completed | Brian Mickey | 39 | 2025-03-10 | 2026-11-03 |
| The Impact of Coach-guided Risk Communication on the Risk of Major Depression coach-guided personalized depression risk communication, depression risk information - Major Depressive Episode, Risk Reduction | Not applicable | Recruiting | Dalhousie University | 1000 | 2025-02-10 | 2025-09-02 |
| Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study Major Depressive Disorder (MDD), Major Depressive Episode | Recruiting | Unity Health Toronto | 200 | 2024-12-16 | 2024-12-13 | |
| Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients Ketamine, Placebo - Major Depressive Episode | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2024-10-20 | 2025-09-03 |
| At-Home tDCS as Maintenance Therapy tDCS - MDD, Severe Depression | Not applicable | Recruiting | Technical University of Munich | 30 | 2024-10-01 | 2025-12-08 |
| A Text Messaging Intervention to Reduce Perinatal Depression Risk Text Messaging Intervention - Major Depressive Episode | Not applicable | Completed | University of Massachusetts, Worcester | 40 | 2024-09-05 | 2026-01-27 |
| SAINT for MDD in an Inpatient Setting Follow-on Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| Sensation Seeking and TMS Response in TRD Transcranial Magnetic Stimulation (TMS) - MDD, Severe Depression | Recruiting | Technical University of Munich | 100 | 2024-05-02 | 2026-10-22 | |
| Metabolomics During ElectroConvulsivoTherapy Electroconvulsive therapy - Major Depressive Episode, ECT | Not applicable | Recruiting | Hôpital le Vinatier | 50 | 2024-03-11 | 2025-07-24 |
| Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics Intermittent Theta Burst Transcranial Magnetic Stimulation (Active), Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham) - Major Depressive Episode, Borderline Personality Disorder | Not applicable | Completed | Massachusetts General Hospital | 75 | 2023-11-01 | 2026-07-14 |
| Presynaptic Imaging in Major Depressive Episodes After COVID-19 [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan - Long COVID, Major Depressive Disorder | Recruiting | Centre for Addiction and Mental Health | 90 | 2023-08-22 | 2026-02-11 |
Showing 20 of 73. Sign in to see all of them.
Depression (27) · Depressive Disorder, Major (25) · Bipolar Disorder (12) · Depressive Disorder, Treatment-Resistant (9) · Depressive Disorder (6) · Suicide (6) · Suicidal Ideation (5) · Psychological Well-Being (3) · Anhedonia (2) · Borderline Personality Disorder (2) · Recurrence (2) · Acute Coronary Syndrome (1) · Breast Neoplasms (1) · COVID-19 (1) · Catatonia (1)
Mental Disorders (39) · Mood Disorders (37) · Behavior (32) · Behavioral Symptoms (31) · Depressive Disorder (25) · Bipolar and Related Disorders (12) · Self-Injurious Behavior (9) · Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (5) · Suicide (4) · Disease Attributes (3) · Nervous System Diseases (3) · Neurobehavioral Manifestations (3) · Neurologic Manifestations (3) · Personal Satisfaction (3)
Ketamine (10) · Midazolam (6) · Transcranial Magnetic Stimulation (4) · Blood Specimen Collection (3) · Electroconvulsive Therapy (3) · Sodium Chloride (3) · Citalopram (2) · Magnetic Resonance Spectroscopy (2) · Psychotherapy (2) · Transcranial Direct Current Stimulation (2) · Antipsychotic Agents (1) · Botulinum Toxins, Type A (1) · Buprenorphine (1) · Citric Acid (1) · Esketamine (1)
Assistance Publique - Hôpitaux de Paris (5) · University Hospital, Montpellier (5) · Centre for Addiction and Mental Health (3) · Freie Universität Berlin (2) · Istanbul University - Cerrahpasa (2) · Jiangsu Province Nanjing Brain Hospital (2) · Magnus Medical (2) · NYU Langone Health (2) · New York State Psychiatric Institute (2) · Technical University of Munich (2) · University of British Columbia (2) · Assistance Publique Hopitaux De Marseille (1) · AstraZeneca (1) · Biogen (1) · Bo Hu (1)
United States (24) · France (14) · Canada (10) · Germany (7) · Australia (4) · China (3) · Ireland (2) · Taiwan (2) · Turkey (Türkiye) (2) · Austria (1) · India (1) · Russia (1) · Spain (1) · United Kingdom (1)
Amit Anand, MD (2) · Brandon Bentzley, MD (2) · Declan M McLoughlin, PhD (2) · Emilie Olie, MD PhD (2) · Fei Wang (2) · Fidel Vila-Rodriguez, MD, PhD (2) · Alla Avedisova, Prof (1) · Anatoly Smulevich, Prof (1) · Anthony Rodgers (1) · Brian J Mickey (1) · Brian J Mickey, MD, PhD (1) · Charles Nduka, MA, MD, FRCS (1)
PMID 10735328, PMID 11940851, PMID 1260078, PMID 12827140, PMID 13688369, PMID 17474805, PMID 18291293, PMID 21041614, PMID 22123153, PMID 22858219, PMID 23588951, PMID 23809145, PMID 24337537, PMID 24602409, PMID 25592385, PMID 25629589, PMID 27028832, PMID 28636705, PMID 28739263, PMID 28939116, PMID 28969438, PMID 29269262, PMID 29436330, PMID 29536616, PMID 30124867, PMID 30572160, PMID 31675086, PMID 31881995, PMID 33087184, PMID 34131914, PMID 34510411, PMID 34739064, PMID 35036831, PMID 35944722, PMID 36209675, PMID 36301615, PMID 37224232, PMID 37361338, PMID 37817124, PMID 37891643, PMID 37974160, PMID 38619842, PMID 38867362, PMID 38968425, PMID 39428602, PMID 39551735, PMID 39696180, PMID 39731725, PMID 39884877, PMID 40669702
2019 (2), 2016 (1), 2023 (1), R01MH125160 (1), R34MH130934 (1), R61MH134943 (1)