3 completed, 2 recruiting, 2 terminated, 1 not yet recruiting. 8 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 3, Recruiting 2, Terminated 2, Not yet recruiting 1 |
| Phase 2 | 3 | Terminated 2, Completed 1 |
Follow Major Depressive Episode: new trials by email Literature Review of Major Depressive Episode trials Research Report on Major Depressive Episode
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive Episodes Oral ketamine, Oral midazolam - Major Depressive Episode | Phase 3 | Not yet recruiting | Jawaharlal Institute of Postgraduate Medical Education & Research | 220 | 2026-10-01 | 2026-10-01 |
| Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients Ketamine, Placebo - Major Depressive Episode | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2024-10-20 | 2025-09-03 |
| SAINT for MDD in an Inpatient Setting Follow-on Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition Active SAINT Stimulation, Sham SAINT Stimulation - Major Depressive Disorder, Major Depressive Episode | Phase 2 / Phase 3 | Terminated | Magnus Medical | 2 | 2024-06-30 | 2025-03-24 |
| Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode Buprenorphine, Placebo - Suicidal Ideation, Major Depressive Episode | Phase 3 | Recruiting | Centre Hospitalier Universitaire de Nīmes | 180 | 2021-10-10 | 2025-08-21 |
| Ketamine As an Adjunctive Therapy for Major Depression (2) Ketamine, Midazolam - Major Depressive Episode, Unipolar Depression | Phase 3 | Completed | University of Dublin, Trinity College | 63 | 2021-09-13 | 2025-02-13 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial 7000lux broad-spectrum light, 50lux dim red light - Bipolar Disorder, Major Depressive Episode | Phase 3 | Completed | Northwestern University | 46 | 2009-05-01 | 2016-11-07 |
Depression (5) · Depressive Disorder, Major (3) · Suicidal Ideation (3) · Bipolar Disorder (2) · Depressive Disorder (2) · Depressive Disorder, Treatment-Resistant (1) · Mental Disorders (1)
Behavior (5) · Behavioral Symptoms (5) · Mood Disorders (5) · Mental Disorders (4) · Self-Injurious Behavior (3) · Suicide (3) · Bipolar and Related Disorders (2) · Depressive Disorder (2)
Ketamine (4) · Midazolam (2) · Buprenorphine (1) · Electroconvulsive Therapy (1)
Magnus Medical (2) · Assistance Publique - Hôpitaux de Paris (1) · Bo Hu (1) · Centre Hospitalier Universitaire de Nīmes (1) · Jawaharlal Institute of Postgraduate Medical Education & Research (1) · Northwestern University (1) · University of Dublin, Trinity College (1)
United States (4) · France (2) · India (1) · Ireland (1)
Brandon Bentzley, MD (2) · Amit Anand, MD (1) · Declan M McLoughlin, PhD (1) · Dorothy K Sit, M.D. (1) · Fabrice Jollant, MD (1)
PMID 28969438, PMID 30572160, PMID 37224232, PMID 37361338, PMID 37974160, PMID 40900112, PMID 41123905
2019 (1), 2023 (1), R01MH125160 (1)